Publications
- 2012
- Van de Vijver, P., Scheer, L., van Beijnum, J., Griffioen, A., & Hackeng, T. M. (2012). Application of an omonasteine ligation strategy for the total chemical synthesis of the BRD7 bromodomain. Chemical Communications, 48(75), 9403-9405. https://doi.org/10.1039/c2cc34956f
- Kleinegris, M.-C., Ten Cate-Hoek, A. J., & ten Cate, H. (2012). Coagulation and the vessel wall in thrombosis and atherosclerosis. Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine, 122(11), 557-565. https://doi.org/10.20452/pamw.1464
- Pattaro, C., Köttgen, A., Teumer, A., Garnaas, M., Böger, C. A., Fuchsberger, C., Olden, M., Chen, M.-H., Tin, A., Taliun, D., Li, M., Gao, X., Gorski, M., Yang, Q., Hundertmark, C., Foster, M. C., O'Seaghdha, C. M., Glazer, N., Isaacs, A., ... CARDIoGRAM Consortium (2012). Genome-wide association and functional follow-up reveals new loci for kidney function. Plos Genetics, 8(3), e1002584. https://doi.org/10.1371/journal.pgen.1002584
- Demirkan, A., van Duijn, C. M., Ugocsai, P., Isaacs, A., Pramstaller, P. P., Liebisch, G., Wilson, J. F., Johansson, Å., Rudan, I., Aulchenko, Y. S., Kirichenko, A. V., Janssens, A. C. J. W., Jansen, R. C., Gnewuch, C., Domingues, F. S., Pattaro, C., Wild, S. H., Jonasson, I., Polasek, O., ... DIAGRAM Consortium (2012). Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations. Plos Genetics, 8(2), e1002490. https://doi.org/10.1371/journal.pgen.1002490
- Lance, M. D., Sloep, M., Henskens, Y. M. C., & Marcus, M. A. E. (2012). Mean Platelet Volume as a Diagnostic Marker for Cardiovascular Disease: Drawbacks of Preanalytical Conditions and Measuring Techniques. Clinical and Applied Thrombosis-Hemostasis, 18(6), 561-568. https://doi.org/10.1177/1076029612458147
- Van Kruchten, R., Cosemans, J. M. E. M., & Heemskerk, J. W. M. (2012). Measurement of whole blood thrombus formation using parallel-plate flow chambers - a practical guide. Platelets, 23(3), 229-242. https://doi.org/10.3109/09537104.2011.630848
- Westein, E., de Witt, S., Lamers, M., Cosemans, J. M. E. M., & Heemskerk, J. W. M. (2012). Monitoring in vitro thrombus formation with novel microfluidic devices. Platelets, 23(7), 501-509. https://doi.org/10.3109/09537104.2012.709653
- Dastani, Z., Hivert, M.-F., Timpson, N., Perry, J. R. B., Yuan, X., Scott, R. A., Henneman, P., Heid, I. M., Kizer, J. R., Lyytikäinen, L.-P., Fuchsberger, C., Tanaka, T., Morris, A. P., Small, K., Isaacs, A., Beekman, M., Coassin, S., Lohman, K., Qi, L., ... DIAGRAM+ Consortium (2012). Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. Plos Genetics, 8(3), e1002607. https://doi.org/10.1371/journal.pgen.1002607
- van Ballegooijen, A. J., Snijder, M. B., Visser, M., van den Hurk, K., Kamp, O., Dekker, J. M., Nijpels, G., Stehouwer, C. D. A., Henry, R. M. A., Paulus, W. J., & Brouwer, I. A. (2012). Vitamin D in Relation to Myocardial Structure and Function after Eight Years of Follow-Up: The Hoorn Study. Annals of Nutrition and Metabolism, 60(1), 69-77. https://doi.org/10.1159/000336173
- 2011
- Koenen, R. R., & Weber, C. (2011). Chemokines: established and novel targets in atherosclerosis. EMBO Molecular Medicine, 3(12), 713-725. https://doi.org/10.1002/emmm.201100183
- Butoi, E. D., Gan, A. M., Manduteanu, I., Stan, D., Calin, M., Pirvulescu, M., Koenen, R. R., Weber, C., & Simionescu, M. (2011). Cross talk between smooth muscle cells and monocytes/activated monocytes via CX3CL1/CX3CR1 axis augments expression of pro-atherogenic molecules. Biochimica et Biophysica Acta-Molecular Cell Research, 1813(12), 2026-2035. https://doi.org/10.1016/j.bbamcr.2011.08.009
- Kuijpers, M. J. E., Megens, R. T. A., Nikookhesal, E., Feijge, M. A. H., De Mey, J. G. R., Egbrink, M. G. A. O., van Giezen, J. J. J., & Heemskerk, J. W. M. (2011). Role of newly formed platelets in thrombus formation in rat after clopidogrel treatment: comparison to the reversible binding P2Y(12) antagonist ticagrelor. Thrombosis and Haemostasis, 106(6), 1179-1188. https://doi.org/10.1160/TH11-04-0252
- Mahmoodi, B. K., Mulder, A. B., Waanders, F., Spronk, H. M. H., Mulder, E. R., Slagman, M. C. J., Vogt, L., Navis, G., Ten Cate, H., Kluin-Nelemans, H. C., & Laverman, G. D. (2011). The impact of antiproteinuric therapy on the prothrombotic state in patients with overt proteinuria. Journal of Thrombosis and Haemostasis, 9(12), 2416-2423. https://doi.org/10.1111/j.1538-7836.2011.04525.x
- Wildhagen, K. C. A. A., Lutgens, E., Loubele, S. T. G. B., ten Cate, H., & Nicolaes, G. A. F. (2011). The structure-function relationship of activated protein C Lessons from natural and engineered mutations. Thrombosis and Haemostasis, 106(6), 1034-1045. https://doi.org/10.1160/TH11-08-0522
- Liehn, E. A., Tuchscheerer, N., Kanzler, I., Drechsler, M., Fraemohs, L., Schuh, A., Koenen, R. R., Zander, S., Soehnlein, O., Hristov, M., Grigorescu, G., Urs, A. O., Leabu, M., Bucur, I., Merx, M. W., Zernecke, A., Ehling, J., Gremse, F., Lammers, T., ... Weber, C. (2011). Double-Edged Role of the CXCL12/CXCR4 Axis in Experimental Myocardial Infarction. Journal of the American College of Cardiology, 58(23), 2415-2423. https://doi.org/10.1016/j.jacc.2011.08.033
- Winckers, K., Siegerink, B., Duckers, C., Maurissen, L. F., Tans, G., Castoldi, E., Spronk, H. M. H., Ten Cate, H., Algra, A., Hackeng, T. M., & Rosendaal, F. R. (2011). Increased tissue factor pathway inhibitor activity is associated with myocardial infarction in young women: results from the RATIO study. Journal of Thrombosis and Haemostasis, 9(11), 2243-2250. https://doi.org/10.1111/j.1538-7836.2011.04497.x
- Tchaikovski, S. N., Thomassen, M. C. L. G. D., Costa, S.-D., Peeters, L. L. H., & Rosing, J. (2011). Role of protein S and tissue factor pathway inhibitor in the development of activated protein C resistance early in pregnancy in women with a history of preeclampsia. Thrombosis and Haemostasis, 106(5), 914-921. https://doi.org/10.1160/TH11-04-0244
- Strijkers, R. H. W., Ten Cate-Hoek, A. J., Bukkems, S. F. F. W., & Wittens, C. H. A. (2011). Management of deep vein thrombosis and prevention of post-thrombotic syndrome. BMJ, 343(7830), 8. https://doi.org/10.1136/bmj.d5916
- Laeremans, H., Hackeng, T. M., van Zandvoort, M. A. M. J., Thijssen, V. L. J. L., Janssen, B. J. A., Ottenheijm, H. C. J., Smits, J. F. M., & Blankesteijn, W. M. (2011). Blocking of Frizzled Signaling With a Homologous Peptide Fragment of Wnt3a/Wnt5a Reduces Infarct Expansion and Prevents the Development of Heart Failure After Myocardial Infarction. Circulation, 124(15), 1626-U107. https://doi.org/10.1161/CIRCULATIONAHA.110.976969
- Konings, J., Govers-Riemslag, J. W. P., Philippou, H., Mutch, N. J., Borissoff, J. I., Allan, P., Mohan, S., Tans, G., ten Cate, H., & Ariens, R. A. S. (2011). Factor XIIa regulates the structure of the fibrin clot independently of thrombin generation through direct interaction with fibrin. Blood, 118(14), 3942-3951. https://doi.org/10.1182/blood-2011-03-339572
- International Consortium for Blood Pressure Genome-Wide Association Studies (2011). Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature, 478(7367), 103-109. https://doi.org/10.1038/nature10405
- Soehnlein, O., Wantha, S., Simsekyilmaz, S., Doering, Y., Megens, R. T. A., Mause, S. F., Drechsler, M., Smeets, R., Weinandy, S., Schreiber, F., Gries, T., Jockenhoevel, S., Moeller, M., Vijayan, S., van Zandvoort, M. A. M. J., Agerberth, B., Pham, C. C. T. N., Gallo, R. L., Hackeng, T. M., ... Weber, C. (2011). Neutrophil-Derived Cathelicidin Protects from Neointimal Hyperplasia. Science Translational Medicine, 3(103), 10. https://doi.org/10.1126/scitranslmed.3002531
- Surakka, I., Isaacs, A., Karssen, L. C., Laurila, P.-P. P., Middelberg, R. P. S., Tikkanen, E., Ried, J. S., Lamina, C., Mangino, M., Igl, W., Hottenga, J.-J., Lagou, V., van der Harst, P., Mateo Leach, I., Esko, T., Kutalik, Z., Wainwright, N. W., Struchalin, M. V., Sarin, A.-P., ... ENGAGE Consortium (2011). A genome-wide screen for interactions reveals a new locus on 4p15 modifying the effect of waist-to-hip ratio on total cholesterol. Plos Genetics, 7(10), e1002333. https://doi.org/10.1371/journal.pgen.1002333
- Honickel, M., Rieg, A. D., Rossaint, R., Braunschweig, T., Spronk, H. M. H., ten Cate, H., van Oerle, R., Tolba, R., & Grottke, O. (2011). Prothrombin complex concentrate reduces blood loss and enhances thrombin generation in a pig model with blunt liver injury under severe hypothermia. Thrombosis and Haemostasis, 106(4), 724-733. https://doi.org/10.1160/TH11-02-0101
- Bis, J. C., Kavousi, M., Franceschini, N., Isaacs, A., Abecasis, G. R., Schminke, U., Post, W. S., Smith, A. V., Cupples, L. A., Markus, H. S., Schmidt, R., Huffman, J. E., Lehtimäki, T., Baumert, J., Münzel, T., Heckbert, S. R., Dehghan, A., North, K., Oostra, B., ... CARDIoGRAM Consortium (2011). Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque. Nature Genetics, 43(10), 940-7. https://doi.org/10.1038/ng.920
- Panova-Noeva, M., Marchetti, M., Buoro, S., Russo, L., Leuzzi, A., Finazzi, G., Rambaldi, A., Ottomano, C., ten Cate, H., & Falanga, A. (2011). JAK2V617F mutation and hydroxyurea treatment as determinants of immature platelet parameters in essential thrombocythemia and polycythemia vera patients. Blood, 118(9), 2599-2601. https://doi.org/10.1182/blood-2011-02-339655
- Schuur, M., Ikram, M. A., van Swieten, J. C., Isaacs, A., Vergeer-Drop, J. M., Hofman, A., Oostra, B. A., Breteler, M. M. B., & van Duijn, C. M. (2011). Cathepsin D gene and the risk of Alzheimer's disease: a population-based study and meta-analysis. Neurobiology of Aging, 32(9), 1607-14. https://doi.org/10.1016/j.neurobiolaging.2009.10.011
- Panizzi, P., Nahrendorf, M., Figueiredo, J.-L., Panizzi, J., Marinelli, B., Iwamoto, Y., Keliher, E., Maddur, A. A., Waterman, P., Kroh, H. K., Leuschner, F., Aikawa, E., Swirski, F. K., Pittet, M. J., Hackeng, T. M., Fuentes-Prior, P., Schneewind, O., Bock, P. E., & Weissleder, R. (2011). In vivo detection of Staphylococcus aureus endocarditis by targeting pathogen-specific prothrombin activation. Nature Medicine, 17(9), 1142-U153. https://doi.org/10.1038/nm.2423
- Vasina, E. M., Cauwenberghs, S., Feijge, M. A. H., Heemskerk, J. W. M., Weber, C., & Koenen, R. R. (2011). Microparticles from apoptotic platelets promote resident macrophage differentiation. Cell Death & Disease, 2(9), 10. Article e211. https://doi.org/10.1038/cddis.2011.94
- Nergiz-Unal, R., Lamers, M. M. E., Van Kruchten, R., Luiken, J. J., Cosemans, J. M. E. M., Glatz, J. F. C., Kuijpers, M. J. E., & Heemskerk, J. W. M. (2011). Signaling role of CD36 in platelet activation and thrombus formation on immobilized thrombospondin or oxidized low-density lipoprotein. Journal of Thrombosis and Haemostasis, 9(9), 1835-1846. https://doi.org/10.1111/j.1538-7836.2011.04416.x
- Kornfeld, J.-W., Isaacs, A., Vitart, V., Pospisilik, J. A., Meitinger, T., Gyllensten, U., Wilson, J. F., Rudan, I., Campbell, H., Penninger, J. M., Sexl, V., Moriggl, R., van Duijn, C., Pramstaller, P. P., & Hicks, A. A. (2011). Variants in STAT5B associate with serum TC and LDL-C levels. Journal of Clinical Endocrinology & Metabolism, 96(9), E1496-501. https://doi.org/10.1210/jc.2011-0322
- Grottke, O., Braunschweig, T., Spronk, H. M. H., Esch, S., Rieg, A. D., van Oerle, R., ten Cate, H., Fitzner, C., Tolba, R., & Rossaint, R. (2011). Increasing concentrations of prothrombin complex concentrate induce disseminated intravascular coagulation in a pig model of coagulopathy with blunt liver injury. Blood, 118(7), 1943-1951. https://doi.org/10.1182/blood-2011-03-343046
- Schiepers, O. J. G., van Boxtel, M. P. J., de Groot, R. H. M., Jolles, J., Bekers, O., Kok, F. J., Verhoef, P., & Durga, J. (2011). Genetic variation in folate metabolism is not associated with cognitive functioning or mood in healthy adults. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 35(7), 1682-1688. https://doi.org/10.1016/j.pnpbp.2011.06.008
- Ninivaggi, M., Dargaud, Y., Van Oerle, R., De Laat, B., Hemker, H. C., & Lindhout, T. (2011). Thrombin generation assay using factor IXa as a trigger to quantify accurately factor VIII levels in haemophilia A. Journal of Thrombosis and Haemostasis, 9(8), 1549-1555. https://doi.org/10.1111/j.1538-7836.2011.04358.x
- Bouman, H. J., Harmsze, A. M., van Werkum, J. W., Breet, N. J., Bergmeijer, T. O., ten Cate, H., Hackeng, C. M., Deneer, V. H. M., & Ten Berg, J. M. (2011). Variability in on-treatment platelet reactivity explained by CYP2C19*2 genotype is modest in clopidogrel pretreated patients undergoing coronary stenting. Heart, 97(15), 1239-1244. https://doi.org/10.1136/hrt.2010.220509
- Konopatskaya, O., Matthews, S. A., Harper, M. T., Gilio, K., Cosemans, J. M. E. M., Williams, C. M., Navarro, M. N., Carter, D. A., Heemskerk, J. W. M., Leitges, M., Cantrell, D., & Poole, A. W. (2011). Protein kinase C mediates platelet secretion and thrombus formation through protein kinase D2. Blood, 118(2), 416-424. https://doi.org/10.1182/blood-2010-10-312199
- Kilinc, E., Van Oerle, R., Borissoff, J. I., Oschatz, C., Gerlofs Nijland, M. E., Janssen, N. A., Cassee, F. R., Sandstrom, T., Renne, T., Ten Cate, H., & Spronk, H. M. H. (2011). Factor XII activation is essential to sustain the procoagulant effects of particulate matter. Journal of Thrombosis and Haemostasis, 9(7), 1359-1367. https://doi.org/10.1111/j.1538-7836.2011.04280.x
- Demirkan, A., Amin, N., Isaacs, A., Jarvelin, M.-R., Whitfield, J. B., Wichmann, H.-E., Kyvik, K. O. H. M., Rudan, I., Gieger, C., Hicks, A. A., Johansson, Å., Hottenga, J.-J., Smith, J. J., Wild, S. H., Pedersen, N. L., Willemsen, G., Mangino, M., Hayward, C., Uitterlinden, A. G., ... ENGAGE Consortium (2011). Genetic architecture of circulating lipid levels. European Journal of Human Genetics, 19(7), 813-9. https://doi.org/10.1038/ejhg.2011.21
- Heemskerk, J. W. M., Harper, M. T., Cosemans, J. M. E. M., & Poole, A. W. (2011). Unravelling the different functions of protein kinase C isoforms in platelets. Febs Letters, 585(12), 1711-1716. https://doi.org/10.1016/j.febslet.2011.05.017
- Douma, R. A., Mos, I. C. M., Erkens, P. M. G., Nizet, T. A. C., Durian, M. F., Hovens, M. M. C., van Houten, A., Hofstee, H. M. A., Klok, F. A., ten Cate, H., Ullmann, E. F., Buller, H. R., Kamphuisen, P. W., & Huisman, M. V. (2011). Performance of 4 Clinical Decision Rules in the Diagnostic Management of Acute Pulmonary Embolism A Prospective Cohort Study. Annals of Internal Medicine, 154(11), 14-718. https://doi.org/10.7326/0003-4819-154-11-201106070-00002
- Maas, A. H. E. M., van der Schouw, Y. T., Regitz-Zagrosek, V., Swahn, E., Appelman, Y. E., Pasterkamp, G., ten Cate, H., Nilsson, P. M., Huisman, M. V., Stam, H. C. G., Eizema, K., & Stramba-Badiale, M. (2011). Red alert for women's heart: the urgent need for more research and knowledge on cardiovascular disease in women. European Heart Journal, 32(11), 1362-U89. https://doi.org/10.1093/eurheartj/ehr048
- Borissoff, J. I., Spronk, H. M. H., & ten Cate, H. (2011). MECHANISMS OF DISEASE The Hemostatic System as a Modulator of Atherosclerosis. New England Journal of Medicine, 364(18), 1746-1760. https://doi.org/10.1056/NEJMra1011670
- Bastings, M. M. C., Helms, B. A., van Baal, I., Hackeng, T. M., Merkx, M. A. G., & Meijer, E. W. (2011). From Phage Display to Dendrimer Display: Insights into Multivalent Binding. Journal of the American Chemical Society, 133(17), 6636-6641. https://doi.org/10.1021/ja110700x
- Bouman, H. J., van Werkum, J. W., Breet, N. J., ten Cate, H., Hackeng, C. M., & Ten Berg, J. M. (2011). A case-control study on platelet reactivity in patients with coronary stent thrombosis. Journal of Thrombosis and Haemostasis, 9(5), 909-916. https://doi.org/10.1111/j.1538-7836.2011.04255.x
- Castoldi, E., Duckers, C., Radu, C. M., Spiezia, L., Rossetto, V., Tagariello, G., Rosing, J., & Simioni, P. (2011). Homozygous F5 deep-intronic splicing mutation resulting in severe factor V deficiency and undetectable thrombin generation in platelet-rich plasma. Journal of Thrombosis and Haemostasis, 9(5), 959-968. https://doi.org/10.1111/j.1538-7836.2011.04237.x
- Debats, I. B., Koeneman, M. M., Booi, D. I., Bekers, O., & van der Hulst, R. R. W. J. (2011). Intravenous arginine and human skin graft donor site healing: A randomized controlled trial.Burns, 37(3), 420-426. https://doi.org/10.1016/j.burns.2010.06.003
- Wijnen, P. A. H. M., Voorter, C. E., Nelemans, P. J., Verschakelen, J. A., Bekers, O., & Drent, M. (2011). Butyrophilin-like 2 in pulmonary sarcoidosis: a factor for susceptibility and progression?Human Immunology, 72(4), 342-347. https://doi.org/10.1016/j.humimm.2011.01.011
- Trappenburg, M. C., van Schilfgaarde, M., Bredewold, E. O., van Aalderen, M. C., Spronk, H. M. H., ten Cate, H., Leyte, A., & Terpstra, W. E. (2011). Elevated numbers and altered subsets of procoagulant microparticles in breast cancer patients using endocrine therapy. Thrombosis Research, 127(4), 363-369. https://doi.org/10.1016/j.thromres.2010.12.015
- Beijers, H. J. B. H., Henry, R. M., Bravenboer, B., Ferreira, I., Dekker, J. M., Nijpels, G., & Stehouwer, C. D. A. (2011). Metabolic syndrome in nondiabetic individuals associated with maladaptive carotid remodeling: the Hoorn study. American Journal of Hypertension, 24(4), 429-436. https://doi.org/10.1038/ajh.2010.256
- Panova-Noeva, M., Marchetti, M., Spronk, H. M., Russo, L., Diani, E., Finazzi, G., Salmoiraghi, S., Rambaldi, A., Barbui, T., Ten Cate, H., & Falanga, A. (2011). Platelet-induced thrombin generation by the calibrated automated thrombogram assay is increased in patients with essential thrombocythemia and polycythemia vera. American Journal of Hematology, 86(4), 337-342. https://doi.org/10.1002/ajh.21974