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Team Science grant Uyen Nguyen and Roel Meiburg

Team Science grant Uyen Nguyen and Roel Meiburg

18 December 2024

Dr Uyen Nguyen (Dept of Cardiology) and Dr Roel Meiburg (Biomedical Engineer, TU Eindhoven) have been awarded a Dekker Team Science grant by the Dutch Heart Foundation.

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ZonMw grant on appropriate palliative care

ZonMw grant on appropriate palliative care

10 December 2024

Prof. Marc Hemmelder (Dept of Internal Medicine) and his team received a ZonMw grant to promote early palliative care for dialysis patients who are non-waitlisted for transplantation.
 

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Carim Maastricht
Carim Maastricht

Iwan van der Horst

Professor

 Prof. Iwan van der Horst was the principal investigator of the Simple Intensive Care Studies (SICS). In this ongoing registry, up to 2000 patients were included to unravel the diagnostic and prognostic value of physical and physiological examination. Based on the variables included, physicians make clinical decisions in the sickest patients every day. The design paper is published in the BMJ Open.

He was a leading investigator of clinical studies on critically ill patients focusing on hemodynamics, the heart in non-cardiac disease and acute kidney failure at the ICU. The team was involved in initiatives that combine the best of a prospective cohort study (like SICS-I, SOCCS and SICS-II) and randomised controlled trial design. The protocols were based upon results of systematic reviews (see Prospero).

He was also a co-primary investigator in clinical studies on myocardial infarction and heart failure, especially about (glucose) metabolism. Like the Metformin to Reduce Heart Failure After Myocardial Infarction (GIPS-III), NCT01217307. With this study, they obtained a grant of the Netherlands Organization for Health Research and Development (ZonMW; project no. 40-41200-98-9139). Over 20 publications out of this structured study have been published.

Therefore, he was an investigator in the Glucose Insulin Potassium Study (GIPS) I and II, both supported by the Netherlands Heart Foundation (99.028 and 2003B277). Studies on the diagnostic and prognostic value of routine laboratory measures in critically ill patients and implementation study on secondary prevention.

Currently, he is part of a team dedicated to monitoring and big data in critical care patients. A big database is created and cleaned for specific questions regarding mortality. The first projects focus on clustering and validation of prediction models. With the heart on team science, this research line is open to collaboration.

Iwanvdhorst1

Department of Intensive Care
P. Debyelaan 25
6229 HX, Maastricht
Room number: 3.C1.056  
T: +31(0)43 387 63 87 

  • 2020
    • Wiersema, R., Jukarainen, S., Eck, R. J., Kaufmann, T., Koeze, J., Keus, F., Pettila, V., van der Horst, I. C. C., & Vaara, S. T. (2020). Different applications of the KDIGO criteria for AKI lead to different incidences in critically ill patients: a post hoc analysis from the prospective observational SICS-II study. Critical Care, 24(1), Article 164. https://doi.org/10.1186/s13054-020-02886-7
    • Wiersema, R., Jukarainen, S., Vaara, S. T., Poukkanen, M., Lakkisto, P., Wong, H., Linder, A., van der Horst, I. C. C., & Pettila, V. (2020). Two subphenotypes of septic acute kidney injury are associated with different 90-day mortality and renal recovery. Critical Care, 24(1), Article 150. https://doi.org/10.1186/s13054-020-02866-x
    • Granholm, A., Marker, S., Krag, M., Zampieri, F. G., Thorsen-Meyer, H. C., Kaas-Hansen, B. S., van der Horst, I. C. C., Lange, T., Wetterslev, J., Perner, A., & Moller, M. H. (2020). Heterogeneity of treatment effect of prophylactic pantoprazole in adult ICU patients: a post hoc analysis of the SUP-ICU trial. Intensive Care Medicine, 46(4), 717-726. https://doi.org/10.1007/s00134-019-05903-8
    • van Beek, D. E. C., Kuijpers, Y. A. M., Königs, M. H. H., van der Horst, I. C. C., & Scheeren, T. W. L. (2020). Low serum albumin levels and new-onset atrial fibrillation in the ICU: a prospective cohort study. Journal of Critical Care, 56, 26-30. https://doi.org/10.1016/j.jcrc.2019.11.011
    • Keuning, B. E., Kaufmann, T., Wiersema, R., Granholm, A., Pettila, V., Moller, M. H., Christiansen, C. F., Forte, J. C., Snieder, H., Keus, F., Pleijhuis, R. G., van der Horst, I. C. C., & HEALICS consortium (2020). Mortality prediction models in the adult critically ill: A scoping review. Acta Anaesthesiologica Scandinavica, 64(4), 424-442. https://doi.org/10.1111/aas.13527
    • Posma, R. A., Froslev, T., Jespersen, B., van der Horst, I. C. C., Touw, D. J., Thomsen, R. W., Nijsten, M. W., & Christiansen, C. F. (2020). Prognostic impact of elevated lactate levels on mortality in critically ill patients with and without preadmission metformin treatment: a Danish registry-based cohort study. Annals of Intensive Care, 10(1), Article 36. https://doi.org/10.1186/s13613-020-00652-0
    • Gerardu, V. C. A., & van der Horst, I. C. C. (2020). In networks we trust. Netherlands Journal of Critical Care, 28(2), 76-77. https://nvic.nl/sites/nvic.nl/files/Nieuws%20aanmaken/NJCC%202020-2%20Vol%2028%2076-77%20In%20netwrorks%20we%20trust.pdf
    • Kjaer, M. B. N., Meyhoff, T. S., Madsen, M. B., Hjortrup, P. B., Moller, M. H., Egerod, I., Wetterslev, J., Lange, T., Cronhjort, M., Laake, J. H., Jakob, S. M., Nalos, M., Pettila, V., van der Horst, I. C. C., Ostermann, M., Mouncey, P., Cecconi, M., Ferrer, R., Malbrain, M. L. N. G., ... Perner, A. (2020). Long-term patient-important outcomes after septic shock: A protocol for 1-year follow-up of the CLASSIC trial. Acta Anaesthesiologica Scandinavica, 64(3), 410-416. https://doi.org/10.1111/aas.13519
    • Hiemstra, B., Eck, R. J., Keus, F., & van der Horst, I. C. C. (2020). The authors reply. Critical Care Medicine, 48(2), E154-E154. https://doi.org/10.1097/CCM.0000000000004121
    • Cox, E. G. M., Koster, G., Baron, A., Kaufmann, T., Eck, R. J., Veenstra, T. C., Hiemstra, B., Wong, A., Kwee, T. C., Tulleken, J. E., Keus, F., Wiersema, R., van Der Horst, W. C. C., Dieperink, W., Bleijendaal, R., Cawale, Y. F., Clement, R. P., Dijkhuizen, D., Haker, A., ... SICS Study Group (2020). Should the ultrasound probe replace your stethoscope? A SICS-I sub-study comparing lung ultrasound and pulmonary auscultation in the critically ill. Critical Care, 24(1), Article 14. https://doi.org/10.1186/s13054-019-2719-8
    • Koster, G., Kaufmann, T., Hiemstra, B., Wiersema, R., Vos, M. E., Dijkhuizen, D., Wong, A. R., Scheeren, T. W. L., Hummel, Y. M., Keus, F., & van der Horst, I. C. C. (2020). Feasibility of cardiac output measurements in critically ill patients by medical students. Critical Ultrasound Journal, 12(1), Article 1. https://doi.org/10.1186/s13089-020-0152-5
    • Hagenbeek, F. A., Pool, R., van Dongen, J., Draisma, H. H. M., Jan Hottenga, J., Willemsen, G., Abdellaoui, A., Fedko, I. O., den Braber, A., Visser, P. J., de Geus, E. J. C. N., Willems van Dijk, K., Verhoeven, A., Suchiman, H. E., Beekman, M., Slagboom, P. E., van Duijn, C. M., Harms, A. C., Hankemeier, T., ... BBMRI Metabolomics Consortium (2020). Heritability estimates for 361 blood metabolites across 40 genome-wide association studies. Nature Communications, 11(1), Article 39. https://doi.org/10.1038/s41467-019-13770-6
    • Tas, J., van Gassel, R. J. J., Heines, S. J. H., Mulder, M. M. G., Heijnen, N. F. L., Acampo-de Jong, M. J., Bels, J. L. M., Bennis, F. C., Koelmann, M., Groven, R. V. M., Donkers, M. A., van Rosmalen, F., Hermans, B. J. M., Meex, S. J. R., Mingels, A., Bekers, O., Savelkoul, P., Oude Lashof, A. M. L., Wildberger, J., ... van Bussel, B. C. T. (2020). Serial measurements in COVID-19-induced acute respiratory disease to unravel heterogeneity of the disease course: design of the Maastricht Intensive Care COVID cohort (MaastrICCht). BMJ Open, 10(9), Article 040175. https://doi.org/10.1136/bmjopen-2020-040175
  • 2019
    • Wiersema, R., Eck, R. J., Haapio, M., Koeze, J., Poukkanen, M., Keus, F., van der Horst, I. C. C., Pettila, V., & Vaara, S. T. (2019). Burden of acute kidney injury and 90-day mortality in critically ill patients. Bmc Nephrology, 21(1), Article 1. https://doi.org/10.1186/s12882-019-1645-y
    • Hiemstra, B., Keus, F., Wetterslev, J., Gluud, C., & van der Horst, I. C. C. (2019). DEBATE-statistical analysis plans for observational studies. BMC Medical Research Methodology, 19(1), Article 233. https://doi.org/10.1186/s12874-019-0879-5
    • Eck, R. J., Bult, W., Wetterslev, J., Gans, R. O. B., Meijer, K., van Der Horst, I. C. C., & Keus, F. (2019). Low Dose Low-Molecular-Weight Heparin for Thrombosis Prophylaxis: Systematic Review with Meta-Analysis and Trial Sequential Analysis. Journal of Clinical Medicine, 8(12), Article 2039. https://doi.org/10.3390/jcm8122039
    • Lemkes, J. S., Janssens, G. N., van der Hoeven, N. W., Jewbali, L. S. D., Dubois, E. A., Meuwissen, M., Rijpstra, T. A., Bosker, H. A., Blans, M. J., Bleeker, G. B., Baak, R., Vlachojannis, G. J., Eikemans, B. J. W., van der Harst, P., van der Horst, I. C. C., Voskuil, M., van der Heijden, J. J., Beishuizen, A., Stoel, M., ... van Royen, N. (2019). Coronary Angiography after Cardiac Arrest without ST-Segment Elevation. New England Journal of Medicine, 380(15), 1397-1407. https://doi.org/10.1056/NEJMoa1816897
    • Kaufmann, T., Forte, J. C., Hiemstra, B., Wiering, M. A., Grzegorczyk, M., Epema, A. H., van der Horst, I. C. C., & SICS Study Group (2019). A Bayesian Network Analysis of the Diagnostic Process and its Accuracy to Determine How Clinicians Estimate Cardiac Function in Critically Ill Patients: Prospective Observational Cohort Study. JMIR Medical Informatics, 7(4), 214-224. Article 15358. https://doi.org/10.2196/15358
  • 2016
    • Hassell, M. E. C. J., Delewi, R., Lexis, C. P. H., Smulders, M. W., Hirsch, A., Wagner, G., Bekkers, S. C. A. M., van der Horst, I. C. C., Zijlstra, F., van Rossum, A. C., Piek, J. J., van der Harst, P., & Nijveldt, R. (2016). The relationship between terminal QRS distortion on initial ECG and final infarct size at 4 months in conventional ST- segment elevation myocardial infarct patients. Journal of Electrocardiology, 49(3), 292-299. https://doi.org/10.1016/j.jelectrocard.2016.03.009
  • 2012
    • Willemsen, S., Hartog, J. W. L., van Veldhuisen, D. J., van der Meer, P., Roze, J. F., Jaarsma, T., Schalkwijk, C., van der Horst, I. C. C., Hillege, H. L., & Voors, A. A. (2012). The role of advanced glycation end-products and their receptor on outcome in heart failure patients with preserved and reduced ejection fraction. American Heart Journal, 164(5), 742-U146. https://doi.org/10.1016/j.ahj.2012.07.027
  • 2011
    • Lexis, C. P. H., van der Horst, I. C. C., Rahel, B. M., Lexis, M. A. S., Kampinga, M. A., Gu, Y. L., de Smet, B. J. G. L., & Zijlstra, F. (2011). Impact of Chronic Total Occlusions on Markers of Reperfusion, Infarct Size, and Long-Term Mortality: A Substudy from the TAPAS-Trial. Catheterization and Cardiovascular interventions, 77(4), 484-491. https://doi.org/10.1002/ccd.22664
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