Mark Post

Professor

Mark Post is professor of Physiology and from 2004 until April 2019, Chair of Physiology. Prof. Mark Post received his medical degree from the University of Utrecht in 1982 and, at the same University, his PhD in 1989. As a post-doc, he joined Experimental Cardiology (Prof. C. Borst) to set up a Vascular Biology programme. From 1989 to 1996, he was senior investigator at the Royal Dutch Academy of Science. In 1996, Prof. Mark Post was appointed full time assistant professor in Medicine at Harvard Medical School, Boston, MA and continued research in Vascular Biology and more specifically neovascularisation. In 2001, he was appointed associate professor of Medicine and of Physiology at Dartmouth Medical School, Hanover, NH.

A year later, in July 2002, Mark Post returned to the Netherlands as a Professor of Vascular Physiology at the Maastricht University and Professor of Angiogenesis in Tissue Engineering at the Technical University Eindhoven. He was the Chair of the Department of Physiology at Maastricht UMC+ from 2004-2019 and is Chairman of the Dutch Society of Physiology. His main research interests are vascular biology and tissue engineering of blood vessels and skeletal muscle. These subjects are studied from their basic molecular aspects and cellular mechanisms up to preclinical models and eventually, patients and consumers. In addition, he pioneered the creation of meat from stem cells and presented the world’s first hamburger from cultured beef in 2013. As a result, he was awarded the World Technology Award for solutions that benefit the environment at the World Technology Network summit in 2013. Prof. Mark Post co-authored 175 papers in leading peer-reviewed scientific journals (Hirsch-index: 55, 10,700 citations) and received during his career close to 45 M€ in funding and awards from different sources including government, charity and industry.

He recently co-founded and is CSO of Qorium and MosaMeat, two start-ups respectively commercialising the technologies to produce bovine leather and cultured meat using tissue engineering. He is CEO of Cell2Tissue, a company that aims to develop technology platforms to support a variety of applications of tissue engineering

Department of Physiology
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: 3.132
T: +31(0)43 388 10 85

2016
- Hendrikx, G., Vries, M. H., Bauwens, M., De Saint-Hubert, M., Wagenaar, A., Landry, G., Boonen, L., Post, M. J., & Mottaghy, F. M. (2016). Comparison of LDPI to SPECT perfusion imaging using Tc-99m-sestamibi and Tc-99m-pyrophosphate in a murine ischemic hind limb model of neovascularization. EJNMMI Research, 6(1), Article 44. https://doi.org/10.1186/s13550-016-0199-2
- Geenen, I. L., Kolk, F. F., Molin, D. G., Wagenaar, A., Compeer, T., Tordoir, J., Schurink, G., de Mey, J., & Post, M. J. (2016). Nitric Oxide Resistance Reduces Arteriovenous Fistula Maturation in Chronic Kidney Disease in Rats. PLOS ONE, 11(1), Article e0146212. https://doi.org/10.1371/journal.pone.0146212
- Wagenaar, A., Wiegerinck, R. F., Heijnen, V. V. T., & Post, M. J. (2016). Percutaneous microembolization of the left coronary artery to model ischemic heart disease in rats. Lab Animal, 45(1), 20-27. https://doi.org/10.1038/laban.909
- Hendrikx, G., Bauwens, M., Wierts, R., Mottaghy, F. M., & Post, M. J. (2016). Left ventricular function measurements in a mouse myocardial infarction model Comparison between 3D-echocardiography and ECG-gated SPECT. Nuklearmedizin, 55(3), 115-122. https://doi.org/10.3413/Nukmed-0776-15-11
2015
- van Haare, J., Kooi, M. E., Vink, H., Post, M. J., van Teeffelen, J. W. G. E., Slenter, J., Munts, C., Cobelens, H., Strijkers, G. J., Koehn, D., & van Bilsen, M. (2015). Early impairment of coronary microvascular perfusion capacity in rats on a high fat diet. Cardiovascular Diabetology, 14(1), Article 150. https://doi.org/10.1186/s12933-015-0312-2
- Vissenberg, R., van Dijk, M. M., Fliers, E., van der Post, J. A. M., van Wely, M., Bloemenkamp, K. W. M., Hoek - ten Cate, A., Kuchenbecker, W. K., Verhoeve, H. R., Scheepers, H. C. J., Rombout-de Weerd, S., Koks, C., Zwart, J. J., Broekmans, F., Verpoest, W., Christiansen, O. B., Post, M., Papatsonis, D. N. M., Verberg, M. F. G., ... Goddijn, M. (2015). Effect of levothyroxine on live birth rate in euthyroid women with recurrent miscarriage and TPO antibodies (T4-LIFE study). Contemporary Clinical Trials, 44, 134-138. https://doi.org/10.1016/j.cct.2015.08.005
- Geenen, I. L. A., Molin, D. G. M., van den Akker, N. M. S., Jeukens, F., Spronk, H. M., Schurink, G. W. H., & Post, M. J. (2015). Endothelial cells (ECs) for vascular tissue engineering: venous ECs are less thrombogenic than arterial ECs. Journal of Tissue Engineering and Regenerative Medicine, 9(5), 564-576. https://doi.org/10.1002/term.1642
- Vries, M. H. M., Wagenaar, A., Verbruggen, S. E. L., Molin, D. G. M., Dijkgraaf, I., Hackeng, T., & Post, M. J. (2015). CXCL1 promotes arteriogenesis through enhanced monocyte recruitment into the peri-collateral space. Angiogenesis, 18(2), 163-171. https://doi.org/10.1007/s10456-014-9454-1
- Vries, M. H. M., Wagenaar, A., Verbruggen, S. E. L., Molin, D. G. M., Dijkgraaf, I., Hackeng, T. H., & Post, M. J. (2015). Erratum to: CXCL1 promotes arteriogenesis through enhanced monocyte recruitment into the peri-collateral space (vol 18, pg 163, 2015). Angiogenesis, 18(2), 173-173. https://doi.org/10.1007/s10456-014-9458-x
- Hendrikx, G., De Saint-Hubert, M., Dijkgraaf, I., Bauwens, M., Douma, K., Wierts, R., Pooters, I., van den Akker, N. M., Hackeng, T. M., Post, M. J., & Mottaghy, F. M. (2015). Molecular imaging of angiogenesis after myocardial infarction by (111)In-DTPA-cNGR and (99m)Tc-sestamibi dual-isotope myocardial SPECT. EJNMMI Research, 5(1), 13-22. Article 2. https://doi.org/10.1186/s13550-015-0081-7
- Caolo, V., Swennen, G., Chalaris, A., Wagenaar, A., Verbruggen, S., Rose-John, S., Molin, D. G. M., Vooijs, M., & Post, M. J. (2015). ADAM10 and ADAM17 have opposite roles during sprouting angiogenesis. Angiogenesis, 18(1), 13-22. https://doi.org/10.1007/s10456-014-9443-4
- Moritz, M. S. M., Verbruggen, S. E. L., & Post, M. J. (2015). Alternatives for large-scale production of cultured beef: A review. Journal of Integrative Agriculture, 14(2), 208-216. https://doi.org/10.1016/S2095-3119(14)60889-3
2014
- Rahimi, N., Swennen, G., Verbruggen, S., Scibiorek, M., Molin, D. G., & Post, M. J. (2014). Short Stimulation of Electro-Responsive PAA/Fibrin Hydrogel Induces Collagen Production. Tissue Engineering. Part C. Methods , 20(9), 703-713. https://doi.org/10.1089/ten.tec.2013.0596
- Jetten, N., Roumans, N., Gijbels, M. J., Romano, A., Post, M. J., de Winther, M. P., van der Hulst, R. R. W. J., & Xanthoulea, S. (2014). Wound administration of m2-polarized macrophages does not improve murine cutaneous healing responses. PLOS ONE, 9(7), Article e102994. https://doi.org/10.1371/journal.pone.0102994
- Post, M. J. (2014). Cultured beef: medical technology to produce food. Journal of the Science of Food and Agriculture, 94(6), 1039-1041. https://doi.org/10.1002/jsfa.6474
- Geenen, I. L., Verbruggen, S., Molin, D. G., Spronk, H. M., Maessen, J. G., Meesters, B., Schurink, G. W., & Post, M. J. (2014). Phenotypic Fitness of Primary Endothelial Cells Cultured from Patients with High Cardiovascular Risk or Chronic Kidney Disease for Vascular Tissue Engineering. Tissue Engineering, 20(5-6), 1049-1059. https://doi.org/10.1089/ten.tea.2013.0163
- Jetten, N., Verbruggen, S., Gijbels, M. J., Post, M. J., De Winther, M. P. J., & Donners, M. M. P. C. (2014). Anti-inflammatory M2, but not pro-inflammatory M1 macrophages promote angiogenesis in vivo. Angiogenesis, 17(1), 109-118. https://doi.org/10.1007/s10456-013-9381-6
- Post, M. J. (2014). An alternative animal protein source: cultured beef. Annals of the New York Academy of Sciences, 1328(1), 29-33. https://doi.org/10.1111/nyas.12569
2013
- Post, M. J., Rahimi, N., & Caolo, V. (2013). Update on vascularization in tissue engineering. Regenerative Medicine, 8(6), 759-770. https://doi.org/10.2217/rme.13.74
- Jetten, N., Donners, M. M. P. C., Wagenaar, A., Cleutjens, J. P. M., van Rooijen, N., de Winther, M. P. J., & Post, M. J. (2013). Local Delivery of Polarized Macrophages Improves Reperfusion Recovery in a Mouse Hind Limb Ischemia Model. PLOS ONE, 8(7), Article e68811. https://doi.org/10.1371/journal.pone.0068811
- Franke, A. C., Snoek, G. J., de Groot, S., Nene, A. V., Spooren, A. I. F., & Post, M. W. M. (2013). Arm hand skilled performance in persons with a cervical spinal cord injury-long-term follow-up. Spinal Cord, 51(2), 161-164. https://doi.org/10.1038/sc.2012.95
- Rademakers, T., Douma, K., Hackeng, T. M., Post, M. J., Sluimer, J. C., Daemen, M. J. A. P., Biessen, E. A. L., Heeneman, S., & van Zandvoort, M. A. M. J. (2013). Plaque-Associated Vasa Vasorum in Aged Apolipoprotein E-Deficient Mice Exhibit Proatherogenic Functional Features In Vivo. Arteriosclerosis Thrombosis and Vascular Biology, 33(2), 249–256. https://doi.org/10.1161/ATVBAHA.112.300087
- Wolters, M., Mohades, S. G., Hackeng, T. M., Post, M. J., Kooi, M. E., & Backes, W. H. (2013). Clinical perspectives of hybrid proton-fluorine magnetic resonance imaging and spectroscopy.Investigative Radiology, 48(5), 341-350. https://doi.org/10.1097/RLI.0b013e318277528c
- Wolters, M., van Hoof, R. H., Wagenaar, A., Douma, K., van Zandvoort, M. A., Hackeng, T. M., Post, M. J., Backes, W. H., & Kooi, M. E. (2013). MRI artifacts in the ferric chloride thrombus animal model: an alternative solution: preventing MRI artifacts after thrombus induction with a non-ferromagnetic Lewis acid. Journal of Thrombosis and Haemostasis, 11(9), 1766-1769. https://doi.org/10.1111/jth.12340
- Smulders, M. W., Kietselaer, B. L. J. H., Das, M., Wildberger, J. E., Crijns, H. J. G. M., Veenstra, L., Brunner La Rocca, H. P., van Dieijen-Visser, M. P., Mingels, A. M. A., Dagnelie, P. C., Post, M. J., Gorgels, A. P. M., van Asselt, A. D. I., Vogel, G., Schalla, S., Kim, R. J., & Bekkers, S. C. A. M. (2013). The role of cardiovascular magnetic resonance imaging and computed tomography angiography in suspected non-ST-elevation myocardial infarction patients: Design and rationale of the CARdiovascular Magnetic rEsoNance imaging and computed Tomography Angiography (CARMENTA) trial. American Heart Journal, 166(6), 968-975. https://doi.org/10.1016/j.ahj.2013.09.012
2012
- Geenen, I. L., Post, M. J., Molin, D. G. M., Schurink, G. W. H., Maessen, J. G., van Oerle, R., ten Cate, H., & Spronk, H. M. H. (2012). Coagulation on endothelial cells: the underexposed part of Virchow's Triad. Thrombosis and Haemostasis, 108(5), 863-871. https://doi.org/10.1160/TH12-04-0269
- Post, M. J. (2012). Cultured meat from stem cells: Challenges and prospects. Meat Science, 92(3), 297-301. https://doi.org/10.1016/j.meatsci.2012.04.008
- Rahimi, N., Molin, D. G., Cleij, T. J., van Zandvoort, M. A., & Post, M. J. (2012). Electrosensitive Polyacrylic Acid/Fibrin Hydrogel Facilitates Cell Seeding and Alignment. Biomacromolecules, 13(5), 1448-1457. https://doi.org/10.1021/bm300161r
- van den Akker, N. M. S., Kolk, F. F., Jeukens, F., Verbruggen, S., Gagliardi, M., Dullens, S., Heschel, I., Post, M. J., Molin, D. G. M., & Waltenberger, J. (2012). Vascular Potency of Sus Scrofa Bone Marrow-Derived Mesenchymal Stem Cells: A Progenitor Source of Medial but Not Endothelial Cells. Tissue Engineering, 18(7-8), 828-839. https://doi.org/10.1089/ten.tea.2011.0284
- Wolters, M., Oostendorp, M., Coolen, B. F., Post, M. J., Janssen, J. M., Strijkers, G. J., Kooi, M. E., Nicolay, K., & Backes, W. H. (2012). Efficacy of positive contrast imaging techniques for molecular MRI of tumor angiogenesis. Contrast Media & Molecular Imaging, 7(2), 130-139. https://doi.org/10.1002/cmmi.471
- Jaspers, K., Slenter, J. M. G. M., Leiner, T., Wagenaar, A., Post, M. J., & Backes, W. H. (2012). Automated multiscale vessel analysis for the quantification of MR angiography of peripheral arteriogenesis. Journal of Magnetic Resonance Imaging, 35(2), 379-386. https://doi.org/10.1002/jmri.22819
2011
- Langelaan, M. L. P., Boonen, K. J. M., Rosaria-Chak, K. Y., van der Schaft, D. W. J., Post, M. J., & Baaijens, F. P. T. (2011). Advanced maturation by electrical stimulation: Differences in response between C2C12 and primary muscle progenitor cells. Journal of Tissue Engineering and Regenerative Medicine, 5(7), 529-539. https://doi.org/10.1002/term.345
- van den Wijngaard, J. P. H. M., Schulten, H., van Horssen, P., ter Wee, R. D., Siebes, M., Post, M. J., & Spaan, J. A. E. (2011). Porcine coronary collateral formation in the absence of a pressure gradient remote of the ischemic border zone. American Journal of Physiology-heart and Circulatory Physiology, 300(5), H1930-H1937. https://doi.org/10.1152/ajpheart.00403.2010
- Caolo, V., Schulten, H. M., Zhuang, Z. W., Murakami, M., Wagenaar, A., Verbruggen, S., Molin, D. G. M., & Post, M. J. (2011). Soluble Jagged-1 Inhibits Neointima Formation by Attenuating Notch-Herp2 Signaling. Arteriosclerosis Thrombosis and Vascular Biology, 31(5), 1059-U270. https://doi.org/10.1161/ATVBAHA.110.217935
- Jaspers, K., Versluis, B., Leiner, T., Dijkstra, P., Oostendorp, M., van Golde, J. M., Post, M. J., & Backes, W. H. (2011). MR Angiography of Collateral Arteries in a Hind Limb Ischemia Model: Comparison between Blood Pool Agent Gadomer and Small Contrast Agent Gd-DTPA. PLOS ONE, 6(1), 6. https://doi.org/10.1371/journal.pone.0016159
- Oostendorp, M., de Vries, E. E., Slenter, J. M., Peutz-Kootstra, C. J., Snoeijs, M. G., Post, M. J., van Heurn, L. W. E., & Backes, W. H. (2011). MRI of renal oxygenation and function after normothermic ischemia-reperfusion injury.NMR in Biomedicine, 24(2), 194-200. https://doi.org/10.1002/nbm.1572
- Boonen, K. J. M., van der Schaft, D. W. J., Baaijens, F. P. T., & Post, M. J. (2011). Interaction between electrical stimulation, protein coating and matrix elasticity: a complex effect on muscle fibre maturation. Journal of Tissue Engineering and Regenerative Medicine, 5(1), 60-68. https://doi.org/10.1002/term.289
2010
- Caolo, V., van den Akker, N. M. S., Verbruggen, S., Donners, M. M. P. C., Swennen, G., Schulten, H., Waltenberger, J., Post, M. J., & Molin, D. G. M. (2010). Feed-forward Signaling by Membrane-bound Ligand Receptor Circuit THE CASE OF NOTCH DELTA-LIKE 4 LIGAND IN ENDOTHELIAL CELLS. Journal of Biological Chemistry, 285(52), 40681-40689. https://doi.org/10.1074/jbc.M110.176065
- Donners, M. P. C., Wolfs, I. M. J., Olieslagers, S., Mohammadi-Motahhari, Z., Tchaikovski, V., Heeneman, S., van Buul, J. D., Caolo, V., Molin, D. G. M., Post, M. J., & Waltenberger, J. (2010). A Disintegrin and Metalloprotease 10 Is a Novel Mediator of Vascular Endothelial Growth Factor: Induced Endothelial Cell Function in Angiogenesis and Is Associated With Atherosclerosis. Arteriosclerosis Thrombosis and Vascular Biology, 30(11), 2188-U382. https://doi.org/10.1161/ATVBAHA.110.213124
- Jaspers, K., Leiner, T., Dijkstra, P., Oostendorp, M., van Golde, J. M., Post, M. J., & Backes, W. H. (2010). Optimized pharmacokinetic modeling for the detection of perfusion differences in skeletal muscle with DCE-MRI: Effect of contrast agent size. Medical Physics, 37(11), 5746-5755. https://doi.org/10.1118/1.3484057
- Oostendorp, M., Douma, K., Hackeng, T. M., Post, M. J., van Zandvoort, M. A. M. J., & Backes, W. H. (2010). Gadolinium-Labeled Quantum Dots for Molecular Magnetic Resonance Imaging: R-1 Versus R-2 Mapping. Magnetic Resonance in Medicine, 64(1), 291-298. https://doi.org/10.1002/mrm.22342
- Boonen, K. J. M., Langelaan, M. L. P., Polak, R. B., van der Schaft, D. W. J., Baaijens, F. P. T., & Post, M. J. (2010). Effects of a combined mechanical stimulation protocol: Value for skeletal muscle tissue engineering. Journal of Biomechanics, 43(8), 1514-1521. https://doi.org/10.1016/j.jbiomech.2010.01.039
- Douma, K., Oostendorp, M., Slaaf, D. W., Post, M. J., Backes, W. H., & van Zandvoort, M. A. M. J. (2010). Evaluation of Magnetic Resonance Vessel Size Imaging by Two-Photon Laser Scanning Microscopy. Magnetic Resonance in Medicine, 63(4), 930-939. https://doi.org/10.1002/mrm.22248
- Oostendorp, M., Douma, K., Wagenaar, A., Slenter, J. M. G. M., Hackeng, T. M., van Zandvoort, M. A. M. J., Post, M. J., & Backes, W. H. (2010). Molecular Magnetic Resonance Imaging of Myocardial Angiogenesis After Acute Myocardial Infarction. Circulation, 121(6), 775-U85. https://doi.org/10.1161/CIRCULATIONAHA.109.889451
- Langelaan, M. L. P., Boonen, K. J. M., Polak, R. B., Baaijens, F. P. T., Post, M. J., & van der Schaft, D. W. J. (2010). Meet the new meat: tissue engineered skeletal muscle. Trends in Food Science & Technology, 21(2), 59-66. https://doi.org/10.1016/j.tifs.2009.11.001
- Oostendorp, M., Douma, K., Hackeng, T. M., van Zandvoort, M. A. M. J., Post, M. J., & Backes, W. H. (2010). Pharmacokinetics of contrast agents targeted to the tumor vasculature in molecular magnetic resonance imaging. Contrast Media & Molecular Imaging, 5(1), 9-17. https://doi.org/10.1002/cmmi.361
2009
- Lobbes, M. B., Miserus, R. J. H. M., Heeneman, S., Lima Passos, V., Mutsaers, PH., Debernardi, N., Misselwitz, B., Post, M. J., Daemen, M. J. A. P., van Engelshoven, J. M. A., Leiner, T., & Kooi, M. E. (2009). Atherosclerosis: Contrast-enhanced MR imaging of vessel wall in rabbit model - comparison of gadofosveset and gadopentetate dimeglumine. Radiology, 250(3), 682-691. https://doi.org/10.1148/radiol.2503080875

Overview

Latest news & events

Team Science grant Uyen Nguyen and Roel Meiburg

18 December 2024

ZonMw grant on appropriate palliative care

10 December 2024

Mark Post

Professor