Bondue, A., Arbustini, E., Bianco, A., Ciccarelli, M., Dawson, D., De Rosa, M., Hamdani, N., Hilfiker-Kleiner, D., Meder, B., Leite-Moreira, A. F., Thum, T., Tocchetti, C. G., Varricchi, G., Van der Velden, J., Walsh, R., & Heymans, S. (2018). Complex roads from genotype to phenotype in dilated cardiomyopathy: scientific update from the Working Group of Myocardial Function of the European Society of Cardiology. Cardiovascular Research, 114(10), 1287-1303. https://doi.org/10.1093/cvr/cvy122

Breetveld, N. M., Ghossein-Doha, C., van Neer, J., Sengers, M. J. J. M., Geerts, L., van Kuijk, S. M. J., van Dijk, A. P., van der Vlugt, M. J., Heidema, W. M., Brunner-La Rocca, H. P., Scholten, R. R., & Spaanderman, M. E. A. (2018). Decreased endothelial function and increased subclinical heart failure in women several years after pre-eclampsia. Ultrasound in Obstetrics & Gynecology, 52(2), 196-204. https://doi.org/10.1002/uog.17534

van Weeghel, M., Abdurrachim, D., Nederlof, R., Argmann, C. A., Houtkooper, R. H., Hagen, J., Nabben, M., Denis, S., Ciapaite, J., Kolwicz, S. C., Lopaschuk, G. D., Auwerx, J., Nicolay, K., Des Rosiers, C., Wanders, R. J., Zuurbier, C. J., Prompers, J. J., & Houten, S. M. (2018). Increased cardiac fatty acid oxidation in a mousemodel with decreasedmalonyl-CoA sensitivity of CPT1B. Cardiovascular Research, 114(10), 1324-1334. https://doi.org/10.1093/cvr/cvy089

van der Velden, J., Tocchetti, C. G., Varricchi, G., Bianco, A., Sequeira, V., Hilfiker-Kleiner, D., Hamdani, N., Leite-Moreira, A. F., Mayr, M., Falcao-Pires, I., Thum, T., Dawson, D. K., Balligand, J.-L., & Heymans, S. (2018). Metabolic changes in hypertrophic cardiomyopathies: scientific update from the Working Group of Myocardial Function of the European Society of Cardiology. Cardiovascular Research, 114(10), 1273-1280. https://doi.org/10.1093/cvr/cvy147

Poller, W., Dimmeler, S., Heymans, S., Zeller, T., Haas, J., Karakas, M., Leistner, D.-M., Jakob, P., Nakagawa, S., Blankenberg, S., Engelhardt, S., Thum, T., Weber, C., Meder, B., Hajjar, R., & Landmesser, U. (2018). Non-coding RNAs in cardiovascular diseases: diagnostic and therapeutic perspectives. European Heart Journal, 39(29), 2704–2716. https://doi.org/10.1093/eurheartj/ehx165

Fiedler, J., Baker, A. H., Dimmeler, S., Heymans, S., Mayr, M., & Thum, T. (2018). Non-coding RNAs in vascular disease - from basic science to clinical applications: scientific update from the Working Group of Myocardial Function of the European Society of Cardiology. Cardiovascular Research, 114(10), 1281-1286. https://doi.org/10.1093/cvr/cvy121

Bauersachs, J., & Heymans, S. (2018). Scientific updates on the interaction of genes, epigenetics, and multicellularity in cardiovascular diseases: the Working Group of Myocardial Function of the ESC. Cardiovascular Research, 114(10), 1271-1272. https://doi.org/10.1093/cvr/cvy149

Suthahar, N., Meijers, W. C., Ho, J. E., Gansevoort, R. T., Voors, A. A., van der Meer, P., Bakker, S. J. L., Heymans, S., van Empel, V., Schroen, B., van der Harst, P., van Veldhuisen, D. J., & de Boer, R. A. (2018). Sex-specific associations of obesity and N-terminal pro-B-type natriuretic peptide levels in the general population. European journal of heart failure, 20(8), 1205-1214. https://doi.org/10.1002/ejhf.1209

Veugen, M. G. J., Henry, R. M. A., Brunner-La Rocca, H.-P., Dagnelie, P. C., Schram, M. T., van Agtmaal, M. J. M., van der Kallen, C. J. H., Sep, S. J. S., van Boxtel, M. P. J., Bekers, O., Meex, S. J. R., Jansen, J. F. A., Kroon, A. A., & Stehouwer, C. D. A. (2018). Cross-sectional associations between cardiac biomarkers, cognitive performance, and structural brain changes are modified by age: The Maastricht Study. Arteriosclerosis Thrombosis and Vascular Biology, 38(8), 1948-1958. https://doi.org/10.1161/ATVBAHA.118.311082

Remels, A. H. V., Derks, W. J. A., Cillero-Pastor, B., Verhees, K. J. P., Kelders, M. C., Heggermont, W., Carai, P., Summer, G., Ellis, S. R., de Theije, C. C., Heeren, R. M. A., Heymans, S., Papageorgiou, A. P., & van Bilsen, M. (2018). NF-kappa B-mediated metabolic remodelling in the inflamed heart in acute viral myocarditis. Biochimica et Biophysica Acta-Molecular Basis of Disease, 1864(8), 2579-2589. https://doi.org/10.1016/j.bbadis.2018.04.022

Harjola, V.-P., Parissis, J., Brunner-La Rocca, H.-P., Celutkiene, J., Chioncel, O., Collins, S. P., De Backer, D., Filippatos, G. S., Gayat, E., Hill, L., Lainscak, M., Lassus, J., Masip, J., Mebazaa, A., Miro, O., Mortara, A., Mueller, C., Mullens, W., Nieminen, M. S., ... Riley, J. P. (2018). Comprehensive in-hospital monitoring in acute heart failure: applications for clinical practice and future directions for research: A statement from the Acute Heart Failure Committee of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC). European journal of heart failure, 20(7), 1081-1099. https://doi.org/10.1002/ejhf.1204

Papur, O. S., Sun, A., Glatz, J. F. C., Luiken, J. J. F. P., & Nabben, M. (2018). Acute and Chronic Effects of Protein Kinase-D Signaling on Cardiac Energy Metabolism. Frontiers in Cardiovascular Medicine, 5, Article 65. https://doi.org/10.3389/fcvm.2018.00065

Abreu, R. C., & Martins, P. A. (2018). cROSsing the cardiac MIRe: fibroblast-cardiomyocyte ex(o)press. American Journal of Physiology-heart and Circulatory Physiology, 314(6), H1253-H1255. https://doi.org/10.1152/ajpheart.00096.2018

De Windt, L. J., & Giacca, M. (2018). Non-coding RNA function in stem cells and Regenerative Medicine. Non-coding RNA research, 3(2), 39-41. https://doi.org/10.1016/j.ncrna.2018.04.004

Chennupati, R., Meens, M. J., Janssen, B. J., van Dijk, P., Hakvoort, T. B. M., Lamers, W. H., De Mey, J. G. R., & Koehler, S. E. (2018). Deletion of endothelial arginase 1 does not improve vasomotor function in diabetic mice. Physiological Reports, 6(11), Article 13717. https://doi.org/10.14814/phy2.13717

Davarzani, N., Sanders-van Wijk, S., Maeder, M. T., Rickenbacher, P., Smirnov, E., Karel, J., Suter, T., de Boer, R. A., Block, D., Rolny, V., Zaugg, C., Pfisterer, M. E., Peeters, R., & Brunner-La Rocca, H. (2018). Novel concept to guide systolic heart failure medication by repeated biomarker testing—results from TIME-CHF in context of predictive, preventive, and personalized medicine. The EPMA Journal, 9(2), 161-173. https://doi.org/10.1007/s13167-018-0137-7

Mosleh, W., Chaudhari, M. R., Sonkawade, S., Mahajan, S., Khalil, C., Frodey, K., Shah, T., Dahal, S., Karki, R., Katkar, R., Blankesteijn, W. M., Page, B., Pokharel, S., Kim, M., & Sharma, U. C. (2018). The Therapeutic Potential of Blocking Galectin-3 Expression in Acute Myocardial Infarction and Mitigating Inflammation of Infarct Region: A Clinical Outcome-Based Translational Study. Biomarker Insights, 13, 1–10. Article 1177271918771969. https://doi.org/10.1177/1177271918771969

Salvi, D., Ottaviano, M., Muuraiskangas, S., Martinez-Romero, A., Vera-Munoz, C., Triantafyllidis, A., Umpierrez, M. F., Waldmeyer, M. T., Skobel, E., Knackstedt, C., Liedes, H., Honka, A., Luprano, J., Cleland, J. G. F., Stut, W., & Deighan, C. (2018). An m-Health system for education and motivation in cardiac rehabilitation: the experience of HeartCycle guided exercise. Journal of Telemedicine and Telecare, 24(4), 303-316. https://doi.org/10.1177/1357633X17697501

Geraets, I. M. E., Chanda, D., van Tienen, F. H. J., van den Wijngaard, A., Kamps, R., Neumann, D., Liu, Y., Glatz, J. F. C., Luiken, J. J. F. P., & Nabben, M. (2018). Human embryonic stem cell-derived cardiomyocytes as an in vitro model to study cardiac insulin resistance. Biochimica et Biophysica Acta-Molecular Basis of Disease, 1864(5), 1960-1967. https://doi.org/10.1016/j.bbadis.2017.12.025

Coene, K. L. M., Kluijtmans, L. A. J., van der Heeft, E., Engelke, U. F. H., de Boer, S., Hoegen, B., Kwast, H. J. T., van de Vorst, M., Huigen, M. C. D. G., Keularts, I. M. L. W., Schreuder, M. F., van Karnebeek, C. D. M., Wortmann, S. B., de Vries, M. C., Janssen, M. C. H., Gilissen, C., Engel, J., & Wevers, R. A. (2018). Next-generation metabolic screening: targeted and untargeted metabolomics for the diagnosis of inborn errors of metabolism in individual patients. Journal of Inherited Metabolic Disease, 41(3), 337-353. https://doi.org/10.1007/s10545-017-0131-6

Brugts, J. J., Linssen, G. C. M., Hoes, A. W., Brunner-La Rocca, H. P., & CHECK-HF Investigators (2018). Real-world heart failure management in 10,910 patients with chronic heart failure in the Netherlands: Design and rationale of the Chronic Heart failure ESC guideline-based Cardiology practice Quality project (CHECK-HF) registry. Netherlands Heart Journal, 26(5), 272-279. https://doi.org/10.1007/s12471-018-1103-7

Korver-Keularts, I. M. L. W., Wang, P., Waterval, H. W. A. H., Kluijtmans, L. A. J., Wevers, R. A., Langhans, C.-D., Scott, C., Habets, D. D. J., & Bierau, J. (2018). Fast and accurate quantitative organic acid analysis with LC-QTOF/MS facilitates screening of patients for inborn errors of metabolism. Journal of Inherited Metabolic Disease, 41(3), 415-424. https://doi.org/10.1007/s10545-017-0129-0

De Ruysscher, D., Dingemans, A.-M., Vooijs, M., & Heymans, S. (2018). PD-(L)1 Inhibition and Cardiac Damage: A Relevant Toxicity?Journal of Thoracic Oncology, 13(4), 478-479. https://doi.org/10.1016/j.jtho.2018.02.008

Loebel, M., Holzhauser, L., Hartwig, J. A., Shukla, P. C., Savvatis, K., Jenke, A., Gast, M., Escher, F., Becker, S. C., Bauer, S., Stroux, A., Beling, A., Kespohl, M., Pinkert, S., Fechner, H., Kuehl, U., Lassner, D., Poller, W., Schultheiss, H.-P., ... Skurk, C. (2018). The forkhead transcription factor Foxo3 negatively regulates natural killer cell function and viral clearance inmyocarditis. European Heart Journal, 39(10), 876-887. https://doi.org/10.1093/eurheartj/ehx624

Verdonschot, J. A. J., Hazebroek, M. R., Derks, K. W. J., Aizpurua, A. B., Merken, J. J., Wang, P., Bierau, J., van den Wijngaard, A., Schalla, S. M., Hamid, M. A. A., van Bilsen, M., van Empel, V. P. M., Knackstedt, C., Brunner-La Rocca, H.-P., Brunner, H. G., Krapels, I. P. C., & Heymans, S. R. B. (2018). Titin cardiomyopathy leads to altered mitochondrial energetics, increased fibrosis and long-termlife-threatening arrhythmias. European Heart Journal, 39(10), 864-873. https://doi.org/10.1093/eurheartj/ehx808

Aizpurua, A. B., Franssen, F. M. E., van Empel, V., & Brunner-La Rocca, H.-P. (2018). An old debate still in the beta-phase?European journal of heart failure, 20(3), 557-559. https://doi.org/10.1002/ejhf.1086

Deckx, S., Heggermont, W., Carai, P., Rienks, M., Dresselaers, T., Himmelreich, U., van Leeuwen, R., Lommen, W., van der Velden, J., Gonzalez, A., Diez, J., Papageorgiou, A.-P., & Heymans, S. (2018). Osteoglycin prevents the development of age-related diastolic dysfunction during pressure overload by reducing cardiac fibrosis and inflammation. Matrix Biology, 66, 110-124. https://doi.org/10.1016/j.matbio.2017.09.002

Hazebroek, M. R., Krapels, I., Verdonschot, J., van den Wijngaard, A., Vanhoutte, E., Hoos, M., Snijders, L., van Montfort, L., Witjens, M., Dennert, R., Crijns, H. J. G. M., Brunner-La Rocca, H.-P., Brunner, H. G., & Heymans, S. (2018). Prevalence of Pathogenic Gene Mutations and Prognosis Do Not Differ in Isolated Left Ventricular Dysfunction Compared With Dilated Cardiomyopathy. Circulation-Heart Failure, 11(3), Article e004682 . https://doi.org/10.1161/CIRCHEARTFAILURE.117.004682

Frantz, S., Falcao-Pires, I., Balligand, J.-L., Bauersachs, J., Brutsaert, D., Ciccarelli, M., Dawson, D., de Windt, L. J., Giacca, M., Hamdani, N., Hilfiker-Kleiner, D., Hirsch, E., Leite-Moreira, A., Mayr, M., Thum, T., Tocchetti, C. G., van der Velden, J., Varricchi, G., & Heymans, S. (2018). The innate immune system in chronic cardiomyopathy: a European Society of Cardiology (ESC) scientific statement from the Working Group on Myocardial Function of the ESC. European journal of heart failure, 20(3), 445-459. https://doi.org/10.1002/ejhf.1138

De Majo, F., & Calore, M. (2018). Chromatin remodelling and epigenetic state regulation by non-coding RNAs in the diseased heart. Non-coding RNA research, 3(1), 20-28. https://doi.org/10.1016/j.ncrna.2018.02.003

Lourenco, A. P., Leite-Moreira, A. F., Balligand, J.-L., Bauersachs, J., Dawson, D., de Boer, R. A., de Windt, L. J., Falcao-Pires, I., Fontes-Carvalho, R., Franz, S., Giacca, M., Hilfiker-Kleiner, D., Hirsch, E., Maack, C., Mayr, M., Pieske, B., Thum, T., Tocchetti, C. G., Brutsaert, D. L., & Heymans, S. (2018). An integrative translational approach to study heart failure with preserved ejection fraction: a position paper from the Working Group on Myocardial Function of the European Society of Cardiology. European journal of heart failure, 20(2), 216-227. https://doi.org/10.1002/ejhf.1059

Merken, J., Hazebroek, M., Van Paassen, P., Verdonschot, J., Van Empel, V., Knackstedt, C., Hamid, M. A., Seiler, M., Kolb, J., Hoermann, P., Ensinger, C., Brunner-La Rocca, H.-P., Poelzl, G., & Heymans, S. (2018). Immunosuppressive Therapy Improves Both Short- and Long-Term Prognosis in Patients With Virus-Negative Nonfulminant Inflammatory Cardiomyopathy. Circulation-Heart Failure, 11(2), Article 004228. https://doi.org/10.1161/CIRCHEARTFAILURE.117.004228

Verjans, R., Peters, T., Beaumont, F., van Leeuwen, R., van Herwaarden, T., Verhesen, W., Munts, C., Bijnen, M., Henkens, M., Diez, J., de Windt, L. J., van Nieuwenhoven, F. A., van Bilsen, M., Goumans, M. J., Heymans, S., Gonzalez, A., & Schroen, B. (2018). MicroRNA-221/222 Family Counteracts Myocardial Fibrosis in Pressure Overload-Induced Heart Failure. Hypertension, 71(2), 280-288. https://doi.org/10.1161/HYPERTENSIONAHA.117.10094

Ferreira, J. P., Machu, J.-L., Girerd, N., Jaisser, F., Thum, T., Butler, J., Gonzalez, A., Diez, J., Heymans, S., McDonald, K., Gyongyosi, M., Firat, H., Rossignol, P., Pizard, A., & Zannad, F. (2018). Rationale of the FIBROTARGETS study designed to identify novel biomarkers of myocardial fibrosis. Esc heart failure, 5(1), 139-148. https://doi.org/10.1002/ehf2.12218

Zhang, M., Schiffers, P., Janssen, G., Vrolijk, M., Vangrieken, P., & Haenen, G. R. M. M. (2018). The cardiovascular side effects of Ma Huang due to its use in isolation in the Western world. European Journal of Integrative Medicine, 18, 18-22. https://doi.org/10.1016/j.eujim.2018.01.007

Rech, M., Luiken, J. J. F. P., Glatz, J. F. C., van Bilsen, M., Schroen, B., & Nabben, M. (2018). Assessing fatty acid oxidation flux in rodent cardiomyocyte models. Scientific Reports, 8(1), Article 1505. https://doi.org/10.1038/s41598-018-19478-9

Aimo, A., Januzzi, J. L., Vergaro, G., Ripoli, A., Latini, R., Masson, S., Magnoli, M., Anand, I. S., Cohn, J. N., Tavazzi, L., Tognoni, G., Gravning, J., Ueland, T., Nymo, S. H., Brunner-La Rocca, H.-P., Genis, A. B., Lupon, J., de Boer, R. A., Yoshihisa, A., ... Emdin, M. (2018). Prognostic Value of High-Sensitivity Troponin T in Chronic Heart Failure An Individual Patient Data Meta-Analysis. Circulation, 137(3), 286-297. https://doi.org/10.1161/CIRCULATIONAHA.117.031560

Kuepfer, L., Clayton, O., Thiel, C., Cordes, H., Nudischer, R., Blank, L. M., Baier, V., Heymans, S., Caiment, F., Roth, A., Fluri, D. A., Kelm, J. M., Castell, J., Selevsek, N., Schlapbach, R., Keun, H., Hynes, J., Sarkans, U., Gmuender, H., ... Kleinjans, J. (2018). A model-based assay design to reproduce in vivo patterns of acute drug-induced toxicity. Archives of Toxicology, 92(1), 553-555. https://doi.org/10.1007/s00204-017-2041-7

Gorter, T. M., van Veldhuisen, D. J., Bauersachs, J., Borlaug, B. A., Celutkiene, J., Coats, A. J. S., Crespo-Leiro, M. G., Guazzi, M., Harjola, V.-P., Heymans, S., Hill, L., Lainscak, M., Lam, C. S. P., Lund, L. H., Lyon, A. R., Mebazaa, A., Mueller, C., Paulus, W. J., Pieske, B., ... de Boer, R. A. (2018). Right heart dysfunction and failure in heart failure with preserved ejection fraction: mechanisms and management. Position statement on behalf of the Heart Failure Association of the European Society of Cardiology. European journal of heart failure, 20(1), 16-37. https://doi.org/10.1002/ejhf.1029

Foulquier, S., Daskalopoulos, E. P., Lluri, G., Hermans, K. C. M., Deb, A., & Blankesteijn, W. M. (2018). WNT Signaling in Cardiac and Vascular Disease. Pharmacological Reviews, 70(1), 68-141. https://doi.org/10.1124/pr.117.013896

Zhang, M., Vrolijk, M., & Haenen, G. R. M. M. (2018). The Screening of Anticholinergic Accumulation by Traditional Chinese Medicine. International journal of molecular sciences, 19(1), Article 18. https://doi.org/10.3390/ijms19010018

Smulders, M., Bekkers, B., VAN Cauteren, Y., Liefhebber, A., Vermeer, J. R., Vervuurt, J., van Dieijen - Visser, M. P., Mingels, A., Brunner-La Rocca, H., Dagnelie, P., Wildberger, J., Crijns, H., & Kietselaer, B. (2018). Acute pijn op de borst zonder afwijkend troponine: Is aanvullende niet-invasieve diagnostiek zinvol?Nederlands Tijdschrift voor Geneeskunde, 162(51-52), 1-7. Article D3568. https://www.ntvg.nl/system/files/publications/d3568.pdf

Giamouridis, D., Gao, M., Lai, N. C., Tan, Z., Kim, B. C., Guo, T., Miyanohara, A., Blankesteijn, M., Biessen, E., & Hammond, H. K. (2018). Effects of Urocortin 2 Versus Urocortin 3 Gene Transfer on Left Ventricular Function and Glucose Disposal. JACC: Basic to Translational Science, 3(2), 249-264. https://doi.org/10.1016/j.jacbts.2017.12.004

Nabben, M., Luiken, J. J. F. P., & Glatz, J. F. C. (2018). Metabolic remodelling in heart failure revisited. Nature Reviews Cardiology, 15(12), 780-780. https://doi.org/10.1038/s41569-018-0115-8

Falkenberg, K. D., Braverman, N. E., Moser, A. B., Steinberg, S. J., Klouwer, F. C. C., Schluter, A., Ruiz, M., Pujol, A., Engvall, M., Naess, K., van Spronsen, F., Korver-Keularts, I., Rubio-Gozalbo, M. E., Ferdinandusse, S., Wanders, R. J. A., & Waterham, H. R. (2017). Allelic Expression Imbalance Promoting a Mutant PEX6 Allele Causes Zellweger Spectrum Disorder. American Journal of Human Genetics, 101(6), 965-976. https://doi.org/10.1016/j.ajhg.2017.11.007

Rickenbacher, P., Kaufmann, B. A., Maeder, M. T., Bernheim, A., Goetschalckx, K., Pfister, O., Pfisterer, M., Brunner-La Rocca, H.-P., & Investigators, TIME.-CHF. (2017). Heart failure with mid-range ejection fraction: a distinct clinical entity? Insights from the Trial of Intensified versus standard Medical therapy in Elderly patients with Congestive Heart Failure (TIME-CHF). European journal of heart failure, 19(12), 1586-1596. https://doi.org/10.1002/ejhf.798

Baldewijns, K., Bektas, S., Boyne, J., Rohde, C., De Maesschalck, L., De Bleser, L., Brandenburg, V., Knackstedt, C., Deville, A., Sanders-Van Wijk, S., & La Rocca, H.-P. B. (2017). Improving kNowledge Transfer to Efficaciously RAise the level of Contemporary Treatment in Heart Failure (INTERACT-in-HF): Study protocol of a mixed methods study. International Journal of Care Coordination, 20(4), 171-182. https://doi.org/10.1177/2053434517726318

van Nieuwenhoven, F. A., Munts, C., op't Veld, R. C., Gonzalez, A., Diez, J., Heymans, S., Schroen, B., & van Bilsen, M. (2017). Cartilage intermediate layer protein 1 (CILP1): A novel mediator of cardiac extracellular matrix remodelling. Scientific Reports, 7(1), Article 16042. https://doi.org/10.1038/s41598-017-16201-y