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MLDS grant Sabine Daemen

MLDS grant Sabine Daemen

15 November 2024

Dr Sabine Daemen (Dept of Internal Medicine) received a Career Development Grant (160k) from the Dutch Digestive Foundation (MLDS).

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Our new Division Leaders

Our new Division Leaders

3 October 2024

As of 1 October 2024, Casper Schalkwijk and Joost Lumens have been appointed as Division Leaders Vessels and Heart. Judith Sluimer will success Hugo ten Cate as Division Leader Blood in March 2025.

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Carim Maastricht
Carim Maastricht

Uli Schotten

Professor

Professor Uli Schotten studied medicine at the universities of Aachen, Glasgow, and Valetta. After four years of training in cardiology at the University Hospital of Aachen, he joined the Department of Physiology at Maastricht University in 1998, first as a scholar of the Academy of Sciences of North-Rhine Westfalia and from 1999 on as a staff member of the department. He defended his thesis 'Mechanisms of Atrial Paralysis in Atrial Fibrillation' at Maastricht University in 2003, and received his habilitation in Experimental Cardiology at the University Hospital in Aachen in 2004. Since 2007, he is Principal Investigator at CARIM. In 2011, he was appointed Professor of Cardiac Electrophysiology and became chairman of the Department of Physiology in 2019.

His research interests include cellular and integrated actions of antiarrhythmic drugs, the development of substrates for the perpetuation of atrial fibrillation, invasive and non-invasive quantification of the substrate of atrial fibrillation, interaction between atrial fibrillation and activation of the coagulation system, and three-dimensional computer models of atrial fibrillation. He is coordinator of the CVON network RACE V and PI in numerous national and international research networks. He was member of the European task force for the development of the ESC guidelines for management of atrial fibrillation in 2010, 2012, and 2016. Furthermore, he is member of the Executive Committee of the Network of Competence for Atrial Fibrillation (AFNET), co-founder of the Maastricht University spin-off company YourRhythmics BV, and acts as the chairman of the Strategic board of CARIM.

Uli-schotten

Department of Physiology
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: 3.130
T: +31(0)43 388 12 00

  • 2017
    • Hohl, M., Lau, D. H., Mueller, A., Elliott, A. D., Linz, B., Mahajan, R., Hendriks, J. M. L., Boehn, M., Schotten, U., Sanders, P., & Linz, D. (2017). Concomitant Obesity and Metabolic Syndrome Add to the Atrial Arrhythmogenic Phenotype in Male Hypertensive Rats. Journal of the American Heart Association, 6(9), Article 006717. https://doi.org/10.1161/JAHA.117.006717
    • Lau, D. H., Linz, D., Schotten, U., Mahajan, R., Sanders, P., & Kalman, J. M. (2017). Pathophysiology of Paroxysmal and Persistent Atrial Fibrillation: Rotors, Foci and Fibrosis. Heart Lung and Circulation, 26(9), 887-893. https://doi.org/10.1016/j.hlc.2017.05.119
    • Gharaviri, A., Verheule, S., Eckstein, J., Potse, M., Kuklik, P., Kuijpers, N. H. L., & Schotten, U. (2017). How disruption of endo-epicardial electrical connections enhances endo-epicardial conduction during atrial fibrillation. EP Europace, 19(2), 308-318. https://doi.org/10.1093/europace/euv445
    • Kuklik, P., Zeemering, S., van Hunnik, A., Maesen, B., Pison, L., Lau, D. H., Maessen, J., Podziemski, P., Meyer, C., Schaeffer, B., Crijns, H., Willems, S., & Schotten, U. (2017). Identification of Rotors during Human Atrial Fibrillation Using Contact Mapping and Phase Singularity Detection: Technical Considerations. Ieee Transactions on Biomedical Engineering, 64(2), 310-318. https://doi.org/10.1109/TBME.2016.2554660
    • Spronk, H. M. H., De Jong, A. M., Verheule, S., De Boer, H. C., Maass, A. H., Lau, D. H., Rienstra, M., van Hunnik, A., Kuiper, M., Lumeij, S., Zeemering, S., Linz, D., Kamphuisen, P. W., ten Cate, H., Crijns, H. J., Van Gelder, I. C., van Zonneveld, A. J., & Schotten, U. (2017). Hypercoagulability causes atrial fibrosis and promotes atrial fibrillation. European Heart Journal, 38(1), 38-50. https://doi.org/10.1093/eurheartj/ehw119
    • Kirchhof, P., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castella, M., Diener, H.-C., Heidbuchel, H., Hendriks, J., Hindricks, G., Manolis, A. S., Oldgren, J., Popescu, B. A., Schotten, U., Van Putte, B., Vardas, P., Soc Europea Cardiologia Diagnost T, European Heart Rhythm Assoc, & European Stroke Org (2017). Guía ESC 2016 sobre el diagnóstico y tratamiento de la fibrilación auricular, desarrollada en colaboración con la EACTS. Revista Espanola de Cardiologia, 70(1), 50.E1-50.E84. https://doi.org/10.1016/j.recesp.2016.11.014
    • Di Biase, L., Callans, D., Haeusler, K. G., Hindricks, G., Al-Khalidi, H., Mont, L., Nielsen, J. C., Piccini, J. P., Schotten, U., & Kirchhof, P. (2017). Rationale and design of AXAFA-AFNET 5: an investigator-initiated, randomized, open, blinded outcome assessment, multi-centre trial to comparing continuous apixaban to vitamin K antagonists in patients undergoing atrial fibrillation catheter ablation. EP Europace, 19(1), 132-138. https://doi.org/10.1093/europace/euw368
  • 2016
    • Kirchhof, P., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castella, M., Diener, H.-C., Heidbuchel, H., Hendriks, J., Hindricks, G., Manolis, A. S., Oldgren, J., Popescu, B. A., Schotten, U., Van Putte, B., Vardas, P., Agewall, S., Camm, J., ... Zeppenfeld, K. (2016). 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS. EP Europace, 18(11), 1609-1678. https://doi.org/10.1093/europace/euw295
    • Kirchhof, P., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castella, M., Diener, H.-C., Heidbuchel, H., Hendriks, J., Hindricks, G., Manolis, A. S., Oldgren, J., Popescu, B. A., Schotten, U., Van Putte, B., & Vardas, P. (2016). 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS. European Journal of Cardio-Thoracic Surgery, 50(5), E1-E88. https://doi.org/10.1093/ejcts/ezw313
    • Kuklik, P., Schaeffer, B., Hoffmann, B. A., Ganesan, A. N., Schreiber, D., Moser, J. M., Akbulak, R. O., Sultan, A., Steven, D., Maesen, B., Schotten, U., Meyer, C., & Willems, S. (2016). Local Electrical Dyssynchrony during Atrial Fibrillation: Theoretical Considerations and Initial Catheter Ablation Results. PLOS ONE, 11(10), Article e0164236. https://doi.org/10.1371/journal.pone.0164236
    • Kirchhof, P., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castella, M., Diener, H.-C., Heidbuchel, H., Hendriks, J., Hindricks, G., Manolis, A. S., Oldgren, J., Popescu, B. A., Schotten, U., Van Putte, B., & Vardas, P. (2016). 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS. European Heart Journal, 37(38), 2893-2962. https://doi.org/10.1093/eurheartj/ehw210
    • Linz, D., Hohl, M., Dhein, S., Ruf, S., Reil, J.-C., Kabiri, M., Wohlfart, P., Verheule, S., Boehm, M., Sadowski, T., & Schotten, U. (2016). Cathepsin A mediates susceptibility to atrial tachyarrhythmia and impairment of atrial emptying function in Zucker diabetic fatty rats. Cardiovascular Research, 110(3), 371-380. https://doi.org/10.1093/cvr/cvw071
    • Reilly, S. N., Liu, X., Carnicer, R., Recalde, A., Muszkiewicz, A., Jayaram, R., Carena, M. C., Wijesurendra, R., Stefanini, M., Surdo, N. C., Lomas, O., Ratnatunga, C., Sayeed, R., Krasopoulos, G., Rajakumar, T., Bueno-Orovio, A., Verheule, S., Fulga, T. A., Rodriguez, B., ... Casadei, B. (2016). Up-regulation of miR-31 in human atrial fibrillation begets the arrhythmia by depleting dystrophin and neuronal nitric oxide synthase. Science Translational Medicine, 8(340), Article 340ra74. https://doi.org/10.1126/scitranslmed.aac4296
    • Lau, D. H., Schotten, U., Mahajan, R., Antic, N. A., Hatem, S. N., Pathak, R. K., Hendriks, J. M. L., Kalman, J. M., & Sanders, P. (2016). Novel mechanisms in the pathogenesis of atrial fibrillation: practical applications. European Heart Journal, 37(20), 1573–1581. https://doi.org/10.1093/eurheartj/ehv375
    • Schotten, U., Dobrev, D., Platonov, P. G., Kottkamp, H., & Hindricks, G. (2016). Current controversies in determining the main mechanisms of atrial fibrillation. Journal of Internal Medicine, 279(5), 428-438. https://doi.org/10.1111/joim.12492
    • Lankveld, T., de Vos, C. B., Limantoro, I., Zeemering, S., Dudink, E., Crijns, H. J., & Schotten, U. (2016). Systematic analysis of ECG predictors of sinus rhythm maintenance after electrical cardioversion for persistent atrial fibrillation. Heart Rhythm, 13(5), 1020-1027. https://doi.org/10.1016/j.hrthm.2016.01.004
    • Van Gelder, I. C., Hobbelt, A. H., Marcos, E. G., Schotten, U., Cappato, R., Lewalter, T., Schwieler, J., Rienstra, M., & Boriani, G. (2016). Tailored treatment strategies: a new approach for modern management of atrial fibrillation. Journal of Internal Medicine, 279(5), 457-466. https://doi.org/10.1111/joim.12489
    • Opacic, D., van Bragt, K. A., Nasrallah, H. M., Schotten, U., & Verheule, S. (2016). Atrial metabolism and tissue perfusion as determinants of electrical and structural remodelling in atrial fibrillation. Cardiovascular Research, 109(4), 527-541. https://doi.org/10.1093/cvr/cvw007
    • Kirchhof, P., Goette, A., Naebauer, M., & Schotten, U. (2016). 12 Jahre AFNET. Vom Forschungsnetzwerk zur Academic Research Organisation. Bundesgesundheitsblatt-Gesundheitsforschung-Gesundheitsschutz, 59(4), 514-522. https://doi.org/10.1007/s00103-016-2323-x
    • van Hunnik, A., Lau, D. H., Zeemering, S., Kuiper, M., Verheule, S., & Schotten, U. (2016). Antiarrhythmic effect of vernakalant in electrically remodeled goat atria is caused by slowing of conduction and prolongation of postrepolarization refractoriness. Heart Rhythm, 13(4), 964-972. https://doi.org/10.1016/j.hrthm.2015.12.009
    • Fabritz, L., Guasch, E., Antoniades, C., Bardinet, I., Benninger, G., Betts, T. R., Brand, E., Breithardt, G., Bucklar-Suchankova, G., Camm, A. J., Cartlidge, D., Casadei, B., Chua, W. W., Crijns, H., Deeks, J., Hatem, S., Hidden-Lucet, F., Kääb, S., Maniadakis, N., ... Kirchhof, P. (2016). Expert consensus document: Defining the major health modifiers causing atrial fibrillation: a roadmap to underpin personalized prevention and treatment. Nature Reviews Cardiology, 13(4), 230-237. https://doi.org/10.1038/nrcardio.2015.194
    • Lankveld, T., Zeemering, S., Scherr, D., Kuklik, P., Hoffmann, B. A., Willems, S., Pieske, B., Haissaguerre, M., Jais, P., Crijns, H. J., & Schotten, U. (2016). Atrial Fibrillation Complexity Parameters Derived From Surface ECGs Predict Procedural Outcome and Long-Term Follow-Up of Stepwise Catheter Ablation for Atrial Fibrillation. Circulation-Arrhythmia and Electrophysiology, 9(2), Article e003354. https://doi.org/10.1161/CIRCEP.115.003354
    • Kirchhof, P., Breithardt, G., Bax, J., Benninger, G., Blomstrom-Lundqvist, C., Boriani, G., Brandes, A., Brown, H., Brueckmann, M., Calkins, H., Calvert, M., Christoffels, V., Crijns, H., Dobrev, D., Ellinor, P., Fabritz, L., Fetsch, T., Freedman, S. B., Gerth, A., ... Camm, A. J. (2016). A roadmap to improve the quality of atrial fibrillation management: proceedings from the fifth Atrial Fibrillation Network/European Heart Rhythm Association consensus conference. EP Europace, 18(1), 37-50. https://doi.org/10.1093/europace/euv304
    • Potse, M., Lankveld, T. A. R., Zeemering, S., Dagnelie, P. C., Stehouwer, C. D. A., Henry, R. M., Linnenbank, A. C., Kuijpers, N. H. L., & Schotten, U. (2016). P-wave complexity in normal subjects and computer models. Journal of Electrocardiology, 49(4), 545-553. https://doi.org/10.1016/j.jelectrocard.2016.05.005
  • 2015
    • Schotten, U., Hatem, S., Ravens, U., Jais, P., Mueller, F.-U., Goette, A., Rohr, S., Antoons, G., Pieske, B., Scherr, D., Oto, A., Casadei, B., Verheule, S., Cartlidge, D., Steinmeyer, K., Goetsche, T., Dobrev, D., Kockskaemper, J., Lendeckel, U., ... Camm, A. J. (2015). The European Network for Translational Research in Atrial Fibrillation (EUTRAF): objectives and initial results. EP Europace, 17(10), 1457-1466. https://doi.org/10.1093/europace/euv252
    • Podziemski, P., Kuklik, P., van Hunnik, A., Zeemering, S., Maesen, B., & Schotten, U. (2015). Far-field effect in unipolar electrograms revisited: High-density mapping of atrial fibrillation in humans. IEEE Engineering in Medicine and Biology Society, 2015, 5680-3. https://doi.org/10.1109/EMBC.2015.7319681
    • Lau, D. H., Maesen, B., Zeemering, S., Kuklik, P., van Hunnik, A., Lankveld, T. A. R., Bidar, E., Verheule, S., Nijs, J., Maessen, J., Crijns, H., Sanders, P., & Schotten, U. (2015). Indices of bipolar complex fractionated atrial electrograms correlate poorly with each other and atrial fibrillation substrate complexity. Heart Rhythm, 12(7), 1415-1423. https://doi.org/10.1016/j.hrthm.2015.03.017
    • Lau, D. H., Volders, P. G. A., Kohl, P., Prinzen, F. W., Zaza, A., Kaeaeb, S., Oto, A., & Schotten, U. (2015). Opportunities and challenges of current electrophysiology research: a plea to establish 'translational electrophysiology' curricula. EP Europace, 17(5), 825-833. https://doi.org/10.1093/europace/euu301
    • van Bragt, K. A., Nasrallah, H. M., Kuiper, M., van Hunnik, A., Kuijpers, N. H. L., Schotten, U., & Verheule, S. (2015). Dynamic regulation of atrial coronary blood flow in healthy adult pigs. Heart Rhythm, 12(5), 991-1000. https://doi.org/10.1016/j.hrthm.2015.01.016
    • Pluteanu, F., Hess, J., Plackic, J., Nikonova, Y., Preisenberger, J., Bukowska, A., Schotten, U., Rinne, A., Kienitz, M.-C., Schaefer, M. K. .-H., Weihe, E., Goette, A., & Kockskaemper, J. (2015). Early subcellular Ca2+ remodelling and increased propensity for Ca2+ alternans in left atrial myocytes from hypertensive rats. Cardiovascular Research, 106(1), 87-97. https://doi.org/10.1093/cvr/cvv045
    • Linz, D., van Hunnik, A., Hohl, M., Mahfoud, F., Wolf, M., Neuberger, H.-R., Casadei, B., Reilly, S. N., Verheule, S., Boehm, M., & Schotten, U. (2015). Catheter-Based Renal Denervation Reduces Atrial Nerve Sprouting and Complexity of Atrial Fibrillation in Goats. Circulation-Arrhythmia and Electrophysiology, 8(2), 466-U294. https://doi.org/10.1161/CIRCEP.114.002453
    • Bonizzi, P., Zeemering, S., Karel, J. M. H., Di Marco, L., Uldry, L., Van Zaen, J., Vesin, J.-M., & Schotten, U. (2015). Systematic comparison of non-invasive measures for the assessment of atrial fibrillation complexity: a step forward towards standardization of atrial fibrillation electrogram analysis. EP Europace, 17(2), 318-325. https://doi.org/10.1093/europace/euu202
    • Kuklik, P., Zeemering, S., Maesen, B., Maessen, J., Crijns, H. J., Verheule, S., Ganesan, A. N., & Schotten, U. (2015). Reconstruction of Instantaneous Phase of Unipolar Atrial Contact Electrogram Using a Concept of Sinusoidal Recomposition and Hilbert Transform. Ieee Transactions on Biomedical Engineering, 62(1), 296-302. https://doi.org/10.1109/TBME.2014.2350029
    • Weijs, B., Schotten, U., & Crijns, H. J. G. M. (2015). Pathophysiology of Idiopathic Atrial Fibrillation - Prognostic and Treatment Implications. Current Pharmaceutical Design, 21(5), 551-572. https://doi.org/10.2174/1381612820666140825150057
  • 2014
    • Kuklik, P., Bidar, E., Gharaviri, A., Maessen, J., & Schotten, U. (2014). Application of phase coherence in assessment of spatial alignment of electrodes during simultaneous endocardial-epicardial direct contact mapping of atrial fibrillation. EP Europace, 16 (Suppl 4), iv135-iv140. https://doi.org/10.1093/europace/euu247
    • Limantoro, I., de Vos, C. B., Delhaas, T., Weijs, B., Blaauw, Y., Schotten, U., Kietselaer, B., Pisters, R., & Crijns, H. J. G. M. (2014). Clinical correlates of echocardiographic tissue velocity imaging abnormalities of the left atrial wall during atrial fibrillation. EP Europace, 16(11), 1546-1553. https://doi.org/10.1093/europace/euu047
    • Linz, D., Hunnik, A. V., Ukena, C., Mahfoud, F., Ewen, S., Verheule, S., Böhm, M., & Schotten, U. (2014). Effects of renal denervation on atrial arrhythmogenesis. Future Cardiology, 10(6), 813-22. https://doi.org/10.2217/fca.14.43
    • Greiser, M., Kerfant, B.-G., Williams, G. S. B., Voigt, N., Harks, E., Dibb, K. M., Giese, A., Meszaros, J., Verheule, S., Ravens, U., Allessie, M. A., Gammie, J. S., van der Velden, J., Lederer, W. J., Dobrev, D., & Schotten, U. (2014). Tachycardia-induced silencing of subcellular Ca2+ signaling in atrial myocytes. Journal of Clinical Investigation, 124(11), 4759-4772. https://doi.org/10.1172/JCI70102
    • Linz, D., van Hunnik, A., Ukena, C., Ewen, S., Mahfoud, F., Schirmer, S. H., Lenski, M., Neuberger, H.-R., Schotten, U., & Boehm, M. (2014). Renal denervation: effects on atrial electrophysiology and arrhythmias. Clinical research in cardiology, 103(10), 765-774. https://doi.org/10.1007/s00392-014-0695-1
    • De Vos, C. B., Limantoro, I., Pisters, R., Delhaas, T., Schotten, U., Cheriex, E. C., Tieleman, R. G., & Crijns, H. J. G. M. (2014). The mechanical fibrillation pattern of the atrial myocardium is associated with acute and long-term success of electrical cardioversion in patients with persistent atrial fibrillation. Heart Rhythm, 11(9), 1514-1521. https://doi.org/10.1016/j.hrthm.2014.04.029
    • Verheule, S., Eckstein, J., Linz, D., Maesen, B., Bidar, E., Gharaviri, A., & Schotten, U. (2014). Role of endo-epicardial dissociation of electrical activity and transmural conduction in the development of persistent atrial fibrillation. Progress in Biophysics & Molecular Biology, 115(2-3), 173-185. https://doi.org/10.1016/j.pbiomolbio.2014.07.007
    • Lankveld, T. A. R., Zeemering, S., Crijns, H. J. G. M., & Schotten, U. (2014). The ECG as a tool to determine atrial fibrillation complexity. Heart, 100(14), 1077-1084. https://doi.org/10.1136/heartjnl-2013-305149
    • Wyse, D. G., Van Gelder, I. C., Ellinor, P. T., Go, A. S., Kalman, J. M., Narayan, S. M., Nattel, S., Schotten, U., & Rienstra, M. (2014). Lone Atrial Fibrillation Does it Exist?Journal of the American College of Cardiology, 63(17), 1715-1723. https://doi.org/10.1016/j.jacc.2014.01.023
    • Spronk, H. M. H., de Jong, A. M., Crijns, H. J., Schotten, U., Van Gelder, I. C., & ten Cate, H. (2014). Pleiotropic effects of factor Xa and thrombin: what to expect from novel anticoagulants. Cardiovascular Research, 101(3), 344-351. https://doi.org/10.1093/cvr/cvt343
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