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MLDS grant Sabine Daemen

MLDS grant Sabine Daemen

15 November 2024

Dr Sabine Daemen (Dept of Internal Medicine) received a Career Development Grant (160k) from the Dutch Digestive Foundation (MLDS).

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Our new Division Leaders

Our new Division Leaders

3 October 2024

As of 1 October 2024, Casper Schalkwijk and Joost Lumens have been appointed as Division Leaders Vessels and Heart. Judith Sluimer will success Hugo ten Cate as Division Leader Blood in March 2025.

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Carim Maastricht
Carim Maastricht

Tammo Delhaas

Professor

Tammo Delhaas is Pediatric Cardiologist and Professor of Biomedical Engineering. He obtained his MD at the University of Groningen and received his PhD degree from Maastricht University in 1993 for a thesis on cardiac mechanics. After his training in Pediatrics in Maastricht and Utrecht, he received a Fulbright grant/ICIN-Fellowship and spent one year at the Departments of Bioengineering and Medicine from the UCSD. Thereafter, he trained in Pediatric Cardiology in Aachen and Melbourne. In 2000, he returned to Maastricht as Pediatric Cardiologist and continued his research on the crossroads of (Pediatric) Cardiology, Physiology and Biomedical Engineering. In 2009, he was appointed Professor and Chair of Biomedical Engineering at Maastricht University, where he is involved in projects related to cellular and cardiac mechanics, cardiac pacing, and mathematical modeling of the heart and circulation.

Prof. Tammo Delhaas is heading the CardioVascular System Dynamics Research Group (CVSDRG). With clinical questions regarding (congenital) heart diseases in mind, his research focusses on asynchronous electrical activation, vascular and myocardial structure-function relation, and computer model-assisted diagnosis and treatment of cardiac failure, pulmonary hypertension and congenital heart diseases. Besides standard expertise, CVSDRG uses following techniques/models in which it has expertise of extraordinary quality according to international standards: 1) CircAdapt, a lumped parameter mathematical model of the human heart and circulation that enables real-time simulation of cardiovascular system dynamics in a wide variety of physiological and pathophysiological situations (www.circadapt.org); 2) Finite Element Model of the heart with left and right ventricle, simulating local stress and strain as a function of time with emphasis on adaptation of wall anatomy to local mechanical load; 3) Pulse Wave Propagation and Computational Fluid Dynamics models that predict pressure and flow waveforms after vascular interventions, such as Arterio-Venous Fistula creation for hemodialysis. Prof. Tammo Delhaas serves as a reviewer or member of the editorial board of many journals, and has received grants from, amongst others, the Dutch Heart Foundation, Maastricht UMC+, Province of Limburg, NWO, European Research Council, and the Interuniversity Cardiology Institute of the Netherlands (ICIN).

Tammo-delhaas

Department of Biomedical Engineering
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: 3.366
T:+31(0)43 388 16 67

  • 2019
    • Polavarapu, K., Preethish-Kumar, V., Sekar, D., Vengalil, S., Nashi, S., Mahajan, N. P., Thomas, P. T., Sadasivan, A., Warrier, M., Gupta, A., Arunachal, G., Debnath, M., Keerthipriya, M. S., Pradeep-Chandra-Reddy, C., Puttegowda, A., John, A. P., Tavvala, A., Gunasekaran, S., Sathyaprabha, T. N., ... Nalini, A. (2019). Mutation pattern in 606 Duchenne muscular dystrophy children with a comparison between familial and non-familial forms: a study in an Indian large single-center cohort. Journal of Neurology, 266(9), 2177-2185. https://doi.org/10.1007/s00415-019-09380-3
    • Delhaas, T., Andriessen, P., van Laar, J. O. E. H., Vullings, R., Hermans, B. J. M., Niemarkt, H. J., Jellema, R. K., Ophelders, D. R. M. G., Wolfs, T. G. A. M., Kramer, B. W., & Zwanenburg, A. (2019). Why-aVF can be used in STAN as a proxy for scalp electrode-derived signal; reply to comments by Kjellmer et al.PLOS ONE, 14(8), Article 0221220. https://doi.org/10.1371/journal.pone.0221220
    • Heusinkveld, M. H. G., Delhaas, ET., Lumens, J., Huberts, W., Spronck, B., Hughes, A. D., & Reesink, K. D. (2019). Augmentation index is not a proxy for wave reflection magnitude: mechanistic analysis using a computational model. Journal of Applied Physiology, 127(2), 491-500. https://doi.org/10.1152/japplphysiol.00769.2018
    • Heinen, S. G. H., van den Heuvel, D. A. F., de Vries, J. P. P. M., van de Vosse, F. N., Delhaas, T., & Huberts, W. (2019). A geometry-based model for non-invasive estimation of pressure gradients over iliac artery stenoses. Journal of Biomechanics, 92, 67-75. https://doi.org/10.1016/j.jbiomech.2019.05.030
    • Heusinkveld, M. H. G., Huberts, W., Lumens, J., Arts, T., Delhaas, T., & Reesink, K. D. (2019). Large vessels as a tree of transmission lines incorporated in the CircAdapt whole-heart model: A computational tool to examine heart-vessel interaction. PLoS Computational Biology, 15(7), Article 1007173. https://doi.org/10.1371/journal.pcbi.1007173
    • Bennis, F. C., van Pul, C., van den Bogaart, J. J. L., Andriessen, P., Kramer, B. W., & Delhaas, T. (2019). Artifacts in pulse transit time measurements using standard patient monitoring equipment. PLOS ONE, 14(6), Article 0218784. https://doi.org/10.1371/journal.pone.0218784
    • Hahn, R. T., Waxman, A. B., Denti, P., & Delhaas, T. (2019). Anatomic Relationship of the Complex Tricuspid Valve, Right Ventricle, and Pulmonary Vasculature A Review. JAMA Cardiology, 4(5), 478-487. https://doi.org/10.1001/jamacardio.2019.0535
    • Janousek, J., Kovanda, J., Lozek, M., Tomek, V., Gebauer, R., Kubus, P., & Delhaas, T. (2019). Cardiac Resynchronization Therapy for Treatment of Chronic Subpulmonary Right Ventricular Dysfunction in Congenital Heart Disease. Circulation-Arrhythmia and Electrophysiology, 12(5), Article 007157. https://doi.org/10.1161/circep.119.007157
    • Heinen, S. G. H., Huberts, W., van den Heuvel, D. A. F., van de Vosse, F. N., de Vries, J.-P. P. M., & Delhaas, T. (2019). A comparative study of geometry-based methods and intra-arterial pressure measurements to assess the hemodynamic significance of equivocal iliac artery stenoses. Vascular, 27(2), 119-127. https://doi.org/10.1177/1708538118805659
    • Bol, M. E., Suverein, M. M., Lorusso, R., Delnoij, T. S. R., Bruinsma, G. J. B. B., Otterspoor, L., Kuijpers, M., Lam, K. Y., Vlaar, A. P. J., Kraemer, C. V. E., van der Heijden, J. J., Scholten, E., Driessen, A. H. G., Cabezas, J. M. M., Rittersma, S. Z. H., Heijnen, B. G., Taccone, F. S., Essers, B., Delhaas, T., ... van de Poll, M. C. G. (2019). Early initiation of extracorporeal life support in refractory out-of-hospital cardiac arrest: Design and rationale of the INCEPTION trial. American Heart Journal, 210, 58-68. https://doi.org/10.1016/j.ahj.2018.12.008
    • Hahn, R. T., Delhaas, T., Denti, P., & Waxman, A. B. (2019). The Tricuspid Valve Relationship With the Right Ventricle and Pulmonary Vasculature. JACC-Cardiovascular Imaging, 12(3), 564-565. https://doi.org/10.1016/j.jcmg.2018.11.016
    • Willemen, E., Schreurs, R., Huntjens, P. R., Strik, M., Plank, G., Vigmond, E., Walmsley, J., Vernooy, K., Delhaas, T., Prinzen, F. W., & Lumens, J. (2019). The Left and Right Ventricles Respond Differently to Variation of Pacing Delays in Cardiac Resynchronization Therapy: A Combined Experimental- Computational Approach. Frontiers in physiology, 10(FEB), 1-13. Article 17. https://doi.org/10.3389/fphys.2019.00017
    • van der Waaij, K. M., Heusinkveld, M. H. G., Delhaas, T., Kroon, A. A., & Reesink, K. D. (2019). Do treatment-induced changes in arterial stiffness affect left ventricular structure? A meta-analysis. Journal of Hypertension, 37(2), 253-263. https://doi.org/10.1097/HJH.0000000000001918
    • Lumens, J., Fan, C.-P. S., Walmsley, J., Yim, D., Manlhiot, C., Dragulescu, A., Grosse-Wortmann, L., Mertens, L., Prinzen, F. W., Delhaas, T., & Friedberg, M. K. (2019). Relative Impact of Right Ventricular Electromechanical Dyssynchrony Versus Pulmonary Regurgitation on Right Ventricular Dysfunction and Exercise Intolerance in Patients After Repair of Tetralogy of Fallot. Journal of the American Heart Association, 8(2), Article 010903. https://doi.org/10.1161/JAHA.118.010903
  • 2018
    • Dupuis, L. J., Arts, T., Prinzen, F. W., Delhaas, T., & Lumens, J. (2018). Linking cross-bridge cycling kinetics to response to cardiac resynchronization therapy: a multiscale modelling study. EP Europace, 20, 87-93. https://doi.org/10.1093/europace/euy230
    • Hermans, B. J. M., Stoks, J., Bennis, F. C., Vink, A. S., Garde, A., Wilde, A. A. M., Pison, L., Postema, P. G., & Delhaas, T. (2018). Support vector machine-based assessment of the T-wave morphology improves long QT syndrome diagnosis. EP Europace, 20, 113-119. https://doi.org/10.1093/europace/euy243
    • Dupuis, L. J., Lumens, J., Arts, T., & Delhaas, T. (2018). High tension in sarcomeres hinders myocardial relaxation: A computational study. PLOS ONE, 13(10), Article e0204642. https://doi.org/10.1371/journal.pone.0204642
    • Delhaas, T., Koeken, Y., Latus, H., Apitz, C., & Schranz, D. (2018). Potts Shunt to Be Preferred Above Atrial Septostomy in Pediatric Pulmonary Arterial Hypertension Patients: A Modeling Study. Frontiers in physiology, 9(SEP), Article 1252. https://doi.org/10.3389/fphys.2018.01252
    • Sathyaprabha, T. N., Koot, L. A. M., Hermans, B. H. M., Adoor, M., Sinha, S., Kramer, B. W., Raju, T. R., Satishchandra, P., & Delhaas, T. (2018). Effects of Chronic Carbamazepine Treatment on the ECG in Patients with Focal Seizures. Clinical Drug Investigation, 38(9), 845-851. https://doi.org/10.1007/s40261-018-0677-6
    • Geerdink, L. M., Delhaas, T., Helbing, W. A., Sarvaas, G. J. D. M., ter Heide, H., Rozendaal, L., de Korte, C. L., Peer, P. G. M., Kuipers, I. M., & Kapusta, L. (2018). Paediatric Ebstein's anomaly: how clinical presentation predicts mortality. Archives of Disease in Childhood, 103(9), 859-863. https://doi.org/10.1136/archdischild-2017-313482
    • van den Boom, T., Stevens, R., Delhaas, T., van de Vosse, F., & Huberts, W. (2018). Zero-dimensional lumped approach to incorporate the dynamic part of the pressure at vessel junctions in a 1D wave propagation model. International Journal for Numerical Methods in Biomedical Engineering, 34(9), Article e3116. https://doi.org/10.1002/cnm.3116
    • Filippini, L. H. P. M., Postema, P. G., Zoubin, K., Hermans, B. J. M., Blom, N. A., Delhaas, T., & Wilde, A. A. M. (2018). The brisk-standing-test for long QT syndrome in prepubertal school children: defining normal. EP Europace, 20(FI1), F108-F112. https://doi.org/10.1093/europace/eux259
    • Andriessen, P., Zwanenburg, A., van Laar, J. O. E. H., Vullings, R., Hermans, B. J. M., Niemarkt, H. J., Jellema, R. K., Ophelders, D. R. M. G., Wolfs, T. G. A. M., Kramer, B. W., & Delhaas, T. (2018). ST waveform analysis for monitoring hypoxic distress in fetal sheep after prolonged umbilical cord occlusion. PLOS ONE, 13(4), Article e0195978. https://doi.org/10.1371/journal.pone.0195978
    • Huntjens, P. R., Ploux, S., Strik, M., Walmsley, J., Ritter, P., Haissaguerre, M., Prinzen, F. W., Delhaas, T., Lumens, J., & Bordachar, P. (2018). Electrical Substrates Driving Response to Cardiac Resynchronization Therapy: A Combined Clinical–Computational Evaluation. Circulation-Arrhythmia and Electrophysiology, 11(4), Article e005647. https://doi.org/10.1161/CIRCEP.117.005647
    • Spronck, B., Avolio, A. P., Tan, I., Butlin, M., Reesink, K. D., & Delhaas, T. (2018). Reply: Medical science is based on facts and evidence. Journal of Hypertension, 36(4), 960-962. https://doi.org/10.1097/HJH.0000000000001660
    • Weijs, B., Limantoro, I., Delhaas, T., de Vos, C. B., Blaauw, Y., Houben, R. P. M., Verheule, S., Pisters, R., & Crijns, H. J. G. M. (2018). Cardioversion of persistent atrial fibrillation is associated with a 24-hour relapse gap: Observations from prolonged postcardioversion rhythm monitoring. Clinical Cardiology, 41(3), 366-371. https://doi.org/10.1002/clc.22877
    • Bennis, F. C., Aries, M. J. H., & Delhaas, T. (2018). Letter by Bennis et al Regarding Article, "Cerebral Near-Infrared Spectroscopy: A Potential Approach for Thrombectomy Monitoring". Stroke, 49(3), E135-E135. https://doi.org/10.1161/STROKEAHA.117.020293
    • Heinen, S. G., de Boer, S. W., van den Heuvel, D. A., Huberts, W., Dekker, P., van de Vosse, F. N., Delhaas, T., & de Vries, J.-P. (2018). Hemodynamic significance assessment of equivocal iliac artery stenoses by comparing duplex ultrasonography with intra-arterial pressure measurements. Journal of Cardiovascular Surgery, 59(1), 37-44. https://doi.org/10.23736/S0021-9509.17.10186-2
    • Heusinkveld, M. H. G., Quicken, S., Holtackers, R. J., Huberts, W., Reesink, K. D., Delhaas, T., & Spronck, B. (2018). Uncertainty quantification and sensitivity analysis of an arterial wall mechanics model for evaluation of vascular drug therapies. Biomechanics and modeling in mechanobiology, 17(1), 55-69. https://doi.org/10.1007/s10237-017-0944-0
    • van der Ster, B. J. P., Bennis, F. C., Delhaas, T., Westerhof, B. E., Stok, W. J., & van Lieshout, J. J. (2018). Support Vector Machine Based Monitoring of Cardio-Cerebrovascular Reserve during Simulated Hemorrhage. Frontiers in physiology, 8(JAN), Article 1057. https://doi.org/10.3389/fphys.2017.01057
    • Huberts, W., Heinen, S. G. H., Zonnebeld, N., van den Heuvel, D. A. F., de Vries, J.-P. P. M., Tordoir, J. H. M., Hose, D. R., Delhaas, T., & van de Vosse, F. N. (2018). What is needed to make cardiovascular models suitable for clinical decision support? A viewpoint paper. Journal of Computational Science, 24, 68-84. https://doi.org/10.1016/j.jocs.2017.07.006
  • 2017
    • Heinen, S. G. H., van den Heuvel, D. A. F., Huberts, W., de Boer, S. W., van de Vosse, F. N., Delhaas, T., & de Vries, J.-P. P. M. (2017). In Vivo Validation of Patient-Specific Pressure Gradient Calculations for Iliac Artery Stenosis Severity Assessment. Journal of the American Heart Association, 6(12), Article 007328. https://doi.org/10.1161/JAHA.117.007328
    • Zonnebeld, N., Maas, T. M. G., Huberts, W., van Loon, M. M., Delhaas, T., & Tordoir, J. H. M. (2017). Pre-operative Duplex Ultrasonography in Arteriovenous Fistula Creation: Intra- and Inter-observer Agreement. European Journal of Vascular and Endovascular Surgery, 54(5), 613-619. https://doi.org/10.1016/j.ejvs.2017.08.005
    • Walmsley, J., van Everdingen, W., Cramer, M. J., Prinzen, F. W., Delhaas, T., & Lumens, J. (2017). Combining computer modelling and cardiac imaging to understand right ventricular pump function. Cardiovascular Research, 113(12), 1486-1498. https://doi.org/10.1093/cvr/cvx154
    • van Everdingen, W. M., Walmsley, J., Cramer, M. J., van Hagen, I., De Boeck, B. W. L., Meine, M., Delhaas, T., Doevendans, P. A., Prinzen, F. W., Lumens, J., & Leenders, G. E. (2017). Echocardiographic Prediction of Cardiac Resynchronization Therapy Response Requires Analysis of Both Mechanical Dyssynchrony and Right Ventricular Function: A Combined Analysis of Patient Data and Computer Simulations. Journal of the American Society of Echocardiography, 30(10), 1012-1020. https://doi.org/10.1016/j.echo.2017.06.004
    • Hermans, B. J. M., Vink, A. S., Bennis, F. C., Filippini, L. H., Meijborg, V. M. F., Wilde, A. A. M., Pison, L., Postema, P. G., & Delhaas, T. (2017). The development and validation of an easy to use automatic QT-interval algorithm. PLOS ONE, 12(9), Article 0184352. https://doi.org/10.1371/journal.pone.0184352
    • Janousek, J., Kovanda, J., Lozek, M., Tomek, V., Vojtovic, P., Gebauer, R., Kubus, P., Krejcir, M., Lumens, J., Delhaas, T., & Prinzen, F. (2017). Pulmonary Right Ventricular Resynchronization in Congenital Heart Disease Acute Improvement in Right Ventricular Mechanics and Contraction Efficiency. Circulation-Cardiovascular Imaging, 10(9), Article 006424. https://doi.org/10.1161/CIRCIMAGING.117.006424
    • Bennis, F. C., van der Ster, B. J. P., van Lieshout, J. J., Andriessen, P., & Delhaas, T. (2017). A machine-learning based analysis for the recognition of progressive central hypovolemia. Physiological Measurement, 38(9), 1791-1801. https://doi.org/10.1088/1361-6579/aa7d3d
    • Spronck, B., Delhaas, T., De Lepper, A. G. W., Giroux, J., Goldwasser, F., Boutouyrie, P., Alivon, M., & Reesink, K. D. (2017). Patient-specific blood pressure correction technique for arterial stiffness: evaluation in a cohort on anti-angiogenic medication. Hypertension Research, 40(8), 752-757. https://doi.org/10.1038/hr.2017.32
    • Spronck, B., Avolio, A. P., Tan, I., Butlin, M., Reesink, K. D., & Delhaas, T. (2017). Reply: physics cannot be disputed. Journal of Hypertension, 35(7), 1523-1525. https://doi.org/10.1097/HJH.0000000000001350
    • Willems, M. G. M., Kemp, M. W., Fast, L. A., Wagemaker, N. M. M., Janssen, L. E. W., Newnham, J. P., Payne, M. S., Spiller, O. B., Kallapur, S. G., Jobe, A. H., Delhaas, T., Kramer, B. W., & Wolfs, T. G. A. M. (2017). Pulmonary vascular changes in extremely preterm sheep after intra-amniotic exposure to Ureaplasma parvum and lipopolysaccharide. PLOS ONE, 12(6), Article 0180114. https://doi.org/10.1371/journal.pone.0180114
    • Pluijmert, M., Delhaas, T., de la Parra, A. F., Kroon, W., Prinzen, F. W., & Bovendeerd, P. H. M. (2017). Determinants of biventricular cardiac function: a mathematical model study on geometry and myofiber orientation. Biomechanics and modeling in mechanobiology, 16(2), 721-729. https://doi.org/10.1007/s10237-016-0825-y
    • Palau-Caballero, G., Walmsley, J., Van Empel, V., Lumens, J., & Delhaas, T. (2017). Why septal motion is a marker of right ventricular failure in pulmonary arterial hypertension: mechanistic analysis using a computer model. American Journal of Physiology-heart and Circulatory Physiology, 312(4), H691-H700. https://doi.org/10.1152/ajpheart.00596.2016
    • Delhaas, T. (2017). Is individualized corrected QT interval a silver bullet for the diagnosis of long QT syndrome?Heart Rhythm, 14(3), 383-384. https://doi.org/10.1016/j.hrthm.2017.01.013
    • Zonnebeld, N., Huberts, W., van Loon, M. M., Delhaas, T., & Tordoir, J. H. M. (2017). Preoperative computer simulation for planning of vascular access surgery in hemodialysis patients. Journal of vascular access, 18(1), S118-S124. https://doi.org/10.5301/jva.5000661
    • Kooger, B. L. S., Jaspers, G. J., van Hunnik, A., Delhaas, T., & Vanagt, A. Y. (2017). Deep brain stimulator-induced flutter-like artefact on Holter recording. European Heart Journal, 38(1), 61-61. https://doi.org/10.1093/eurheartj/ehv751
    • Spronck, B., Avolio, A. P., Tan, I., Butlin, M., Reesink, K. D., & Delhaas, T. (2017). Arterial stiffness index beta and cardio-ankle vascular index inherently depend on blood pressure but can be readily corrected. Journal of Hypertension, 35(1), 98-104. https://doi.org/10.1097/HJH.0000000000001132
    • Evers, E. S., Walavalkar, V., Pujar, S., Balasubramanian, L., Prinzen, F. W., Delhaas, T., Vanagt, W. Y., & Maiya, S. (2017). Does heart-type fatty acid-binding protein predict clinical outcomes after pediatric cardiac surgery. Annals of Pediatric Cardiology, 10(3), 245-247. https://doi.org/10.4103/apc.APC_33_17
    • Spronck, B., Delhaas, T., Butlin, M., Reesink, K., & Aviolo, A. P. (2017). Options for Dealing with Pressure Dependence of Pulse Wave Velocity as a Measure of Arterial Stiffness: An Update of Cardio-Ankle Vascular Index (CAVI) and CAVI0. Pulse, 5(1-4), 106-114. https://doi.org/10.1159/000479322
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