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MLDS grant Sabine Daemen

MLDS grant Sabine Daemen

15 November 2024

Dr Sabine Daemen (Dept of Internal Medicine) received a Career Development Grant (160k) from the Dutch Digestive Foundation (MLDS).

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Our new Division Leaders

Our new Division Leaders

3 October 2024

As of 1 October 2024, Casper Schalkwijk and Joost Lumens have been appointed as Division Leaders Vessels and Heart. Judith Sluimer will success Hugo ten Cate as Division Leader Blood in March 2025.

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Carim Maastricht
Carim Maastricht

Joost Lumens

Professor

Professor Joost Lumens studied Biomedical Engineering at the Eindhoven University of Technology where he obtained his MSc degree in Medical Engineering in 2005. He obtained his PhD degree in 2010 at Maastricht University (Dept. of Biomedical Engineering and Dept. of Physiology). During his PhD, he developed and validated a computational model of left-right ventricular interaction dynamics and applied it to study right ventricular failure in patients with pulmonary arterial hypertension. He continued his academic career as a post-doctoral fellow at the LIRYC Electrophysiology and Heart Modelling Institute of CHU de Bordeaux (France), where he combined computational, experimental and clinical data to unravel the working mechanisms of cardiac pacing therapies in the dyssynchronous failing heart.

Since 2012, he is working again at CARIM, where he leads the CircAdapt Research and Education team (www.circadapt.org). In 2021, he was appointed Professor of Computational Cardiology. His research team typically combines advanced computational modelling/simulation techniques with experimental and/or clinical data to gain mechanistic insight in cardiac diseases and their treatments. Importantly, translation of novel mechanistic insights into diagnostic, therapeutic and educational improvement is always pursued. Prof Joost Lumens received prestigious personal (Dutch Heart Foundation & NWO Vidi) and EU consortium funding (H2020 ERA-NET EraCoSysMed Joint Transnational Call 2015; ERA-CVD Joint Transnational Call 2018, coordinator of EMPATHY project; Marie Curie Intelligent Ultrasound, MARCIUS) for projects focussed on computational cardiac electro-mechanics and hemodynamics. He was the chairperson of the European Society of Cardiology (ESC) working group on e-Cardiology (2018-2020) and serves as deputy editor of the European Heart Journal – Digital Health.

Joost-lumens

Department of Biomedical Engineering
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: H3.362
T: +31(0)43 388 16 66

  • 2021
    • Jensen, M. T., Treskes, R. W., Caiani, E. G., Casado-Arroyo, R., Cowie, M. R., Dilaveris, P., Duncker, D., Di Rienzo, M., Frederix, I., De Groot, N., Kolh, P. H., Kemps, H., Mamas, M., McGreavy, P., Neubeck, L., Parati, G., Platonov, P. G., Schmidt-Trucksass, A., Schuuring, M. J., ... Lumens, J. (2021). ESC working group on e-cardiology position paper: Use of commercially available wearable technology for heart rate and activity tracking in primary and secondary cardiovascular prevention - In collaboration with the European Heart Rhythm Association, European Association of Preventive Cardiology, Association of Cardiovascular Nursing and Allied Professionals, Patient Forum, and the Digital Health Committee. European Heart Journal - Digital Health, 2(1), 49-59. https://doi.org/10.1093/ehjdh/ztab011
    • Lyon, A., van Mourik, M., Cruts, L., Heijman, J., Bekkers, S. C. A. M., Schotten, U., Crijns, H. J. G. M., Linz, D., & Lumens, J. (2021). Both beat-to-beat changes in RR-interval and left ventricular filling time determine ventricular function during atrial fibrillation. EP Europace, 23, I21-I28. https://doi.org/10.1093/europace/euaa387
    • van Osta, N., Kirkels, F., Lyon, A., Koopsen, T., van Loon, T., Cramer, M.-J., Teske, A. J., Delhaas, T., & Lumens, J. (2021). Electromechanical substrate characterization in arrhythmogenic cardiomyopathy using imaging-based patient-specific computer simulations. EP Europace, 23, I153-I160. https://doi.org/10.1093/europace/euaa407
    • Dilaveris, P., & Lumens, J. (2021). The ESC Working Group on e-Cardiology. European Heart Journal, 42(2), 143-144. https://doi.org/10.1093/eurheartj/ehaa401
  • 2020
    • Sutanto, H., Lyon, A., Lumens, J., Schotten, U., Dobrev, D., & Heijman, J. (2020). Cardiomyocyte calcium handling in health and disease: Insights from in vitro and in silico studies. Progress in Biophysics & Molecular Biology, 157, 54-75. https://doi.org/10.1016/j.pbiomolbio.2020.02.008
    • Prinzen, F. W., & Lumens, J. (2020). Investigating myocardial work as a CRT response predictor is not a waste of work. European Heart Journal, 41(39), 3824-3826. https://doi.org/10.1093/eurheartj/ehaa677
    • Dilaveris, P., Casado-Arroyo, R., & Lumens, J. (2020). A roadmap to nationwide monitoring of Cardiovascular Implantable Electronic Devices in Greece: staying safe in the era of COVID-19 pandemic. Hellenic Journal of Cardiology, 61(6), 396-397. https://doi.org/10.1016/j.hjc.2020.09.008
    • Lyon, A., Dupuis, L. J., Arts, T., Crijns, H. J. G. M., Prinzen, F. W., Delhaas, T., Heijman, J., & Lumens, J. (2020). Differentiating the effects of β-adrenergic stimulation and stretch on calcium and force dynamics using a novel electromechanical cardiomyocyte model. American Journal of Physiology-heart and Circulatory Physiology, 319(3), H519-H530. https://doi.org/10.1152/ajpheart.00275.2020
    • Lumens, J., Willemen, E., & Prinzen, F. W. (2020). Does the Right Go Wrong During Cardiac Resynchronization Therapy?JACC-Cardiovascular Imaging, 13(7), 1485-1488. https://doi.org/10.1016/j.jcmg.2020.01.009
    • van Osta, N., Lyon, A., Kirkels, F., Koopsen, T., van Loon, T., Cramer, M. J., Teske, A. J., Delhaas, T., Huberts, W., & Lumens, J. (2020). Parameter subset reduction for patient-specific modelling of arrhythmogenic cardiomyopathy-related mutation carriers in the CircAdapt model. Philosophical Transactions of the Royal Society A: mathematical Physical and Engineering Sciences, 378(2173), Article 20190347. https://doi.org/10.1098/rsta.2019.0347
    • Gauthey, A., Willemen, E., Lumens, J., Ploux, S., Bordachar, P., Ritter, P., Prinzen, F. W., Lejeune, S., Pouleur, A.-C., Garnir, Q., Marchandise, S., Scavee, C., Wauters, A., & De Waroux, J.-B. L. P. (2020). Impact of paced left ventricular dyssynchrony on left ventricular reverse remodeling after cardiac resynchronization therapy. Journal of Cardiovascular Electrophysiology, 31(2), 494-502. https://doi.org/10.1111/jce.14330
    • Verdonschot, J. A. J., Merken, J. J., Brunner-La Rocca, H.-P., Hazebroek, M. R., Eurlings, C. G. M. J., Thijssen, E., Wang, P., Weerts, J., van Empel, V., Schummers, G., Schreckenberg, M., van den Wijngaard, A., Lumens, J., Brunner, H. G., Heymans, S. R. B., Krapels, I. P. C., & Knackstedt, C. (2020). Value of Speckle Tracking-Based Deformation Analysis in Screening Relatives of Patients With Asymptomatic Dilated Cardiomyopathy. JACC-Cardiovascular Imaging, 13(2), 549-558. https://doi.org/10.1016/j.jcmg.2019.02.032
    • van Loon, T., Knackstedt, C., Cornelussen, R., Reesink, K., Brunner-La Rocca, H., Delhaas, T., van Empel, V., & Lumens, J. (2020). Increased myocardial stiffness more than impaired relaxation function limits cardiac performance during exercise in heart failure with preserved ejection fraction: a virtual patient study. European Heart Journal - Digital Health, 1(1), 40-50. https://doi.org/10.1093/ehjdh/ztaa009
  • 2019
    • Gorcsan, J., & Lumens, J. (2019). Opposing Wall Pushing and Stretching: Response to Cardiac Resynchronization Therapy Requires Electrical Delay and Viability. JACC-Cardiovascular Imaging, 12(12), 2414-2416. https://doi.org/10.1016/j.jcmg.2019.01.013
    • Walmsley, J., Squara, P., Wolfhard, U., Cornelussen, R., & Lumens, J. (2019). Impact of abrupt versus gradual correction of mitral and tricuspid regurgitation: a modelling study. Eurointervention, 15(10), 902-911. https://doi.org/10.4244/EIJ-D-19-00598
    • Gorcsan, J., Anderson, C. P., Tayal, B., Sugahara, M., Walmsley, J., Starling, R. C., & Lumens, J. (2019). Systolic Stretch Characterizes the Electromechanical Substrate Responsive to Cardiac Resynchronization Therapy. JACC-Cardiovascular Imaging, 12(9), 1741-1752. https://doi.org/10.1016/j.jcmg.2018.07.013
    • Heusinkveld, M. H. G., Delhaas, ET., Lumens, J., Huberts, W., Spronck, B., Hughes, A. D., & Reesink, K. D. (2019). Augmentation index is not a proxy for wave reflection magnitude: mechanistic analysis using a computational model. Journal of Applied Physiology, 127(2), 491-500. https://doi.org/10.1152/japplphysiol.00769.2018
    • Heusinkveld, M. H. G., Huberts, W., Lumens, J., Arts, T., Delhaas, T., & Reesink, K. D. (2019). Large vessels as a tree of transmission lines incorporated in the CircAdapt whole-heart model: A computational tool to examine heart-vessel interaction. PLoS Computational Biology, 15(7), Article 1007173. https://doi.org/10.1371/journal.pcbi.1007173
    • Prinzen, F. W., Willemen, E., & Lumens, J. (2019). LBBB and High Afterload: A Dangerous Liaison?JACC-Cardiovascular Imaging, 12(6), 978-980. https://doi.org/10.1016/j.jcmg.2017.12.002
    • Rech, M., Kuhn, A. R., Lumens, J., Carai, P., van Leeuwen, R., Verhesen, W., Verjans, R., Lecomte, J., Liu, Y., Luiken, J. J. F. P., Mohren, R., Cillero-Pastor, B., Heymans, S., Knoops, K., van Bilsen, M., & Schroen, B. (2019). AntagomiR-103 and-107 Treatment Affects Cardiac Function and Metabolism. Molecular Therapy - Nucleic Acids, 14, 424-437. https://doi.org/10.1016/j.omtn.2018.12.010
    • Mast, T. P., Taha, K., Cramer, M. J., Lumens, J., van der Heijden, J. F., Bouma, B. J., van den Berg, M. P., Asselbergs, F. W., Doevendans, P. A., & Teske, A. J. (2019). The Prognostic Value of Right Ventricular Deformation Imaging in Early Arrhythmogenic Right Ventricular Cardiomyopathy. JACC-Cardiovascular Imaging, 12(3), 446-455. https://doi.org/10.1016/j.jcmg.2018.01.012
    • Willemen, E., Schreurs, R., Huntjens, P. R., Strik, M., Plank, G., Vigmond, E., Walmsley, J., Vernooy, K., Delhaas, T., Prinzen, F. W., & Lumens, J. (2019). The Left and Right Ventricles Respond Differently to Variation of Pacing Delays in Cardiac Resynchronization Therapy: A Combined Experimental- Computational Approach. Frontiers in physiology, 10(FEB), 1-13. Article 17. https://doi.org/10.3389/fphys.2019.00017
    • Niederer, S. A., Lumens, J., & Trayanova, N. A. (2019). Computational models in cardiology. Nature Reviews Cardiology, 16(2), 100-111. https://doi.org/10.1038/s41569-018-0104-y
    • Lumens, J., Fan, C.-P. S., Walmsley, J., Yim, D., Manlhiot, C., Dragulescu, A., Grosse-Wortmann, L., Mertens, L., Prinzen, F. W., Delhaas, T., & Friedberg, M. K. (2019). Relative Impact of Right Ventricular Electromechanical Dyssynchrony Versus Pulmonary Regurgitation on Right Ventricular Dysfunction and Exercise Intolerance in Patients After Repair of Tetralogy of Fallot. Journal of the American Heart Association, 8(2), Article 010903. https://doi.org/10.1161/JAHA.118.010903
    • Noordegraaf, A. V., Chin, K. M., Haddad, F., Hassoun, P. M., Hemnes, A. R., Hopkins, S. R., Kawut, S. M., Langleben, D., Lumens, J., & Naeije, R. (2019). Pathophysiology of the right ventricle and of the pulmonary circulation in pulmonary hypertension: an update. European Respiratory Journal, 53(1), Article 1801900. https://doi.org/10.1183/13993003.01900-2018
    • van Mourik, M. J. W., Zaar, D. V. J., Smulders, M. W., Heijman, J., Lumens, J., Dokter, J. E., Passos, V. L., Schalla, S., Knackstedt, C., Schummers, G., Gjesdal, O., Edvardsen, T., & Bekkers, S. C. A. M. (2019). Adding Speckle-Tracking Echocardiography to Visual Assessment of Systolic Wall Motion Abnormalities Improves the Detection of Myocardial Infarction. Journal of the American Society of Echocardiography, 32(1), 65-73. https://doi.org/10.1016/j.echo.2018.09.007
  • 2018
    • Kirn, B., Walmsley, J., & Lumens, J. (2018). Uniqueness of local myocardial strain patterns with respect to activation time and contractility of the failing heart: a computational study. Biomedical Engineering Online, 17(1), Article 182. https://doi.org/10.1186/s12938-018-0614-1
    • Dupuis, L. J., Arts, T., Prinzen, F. W., Delhaas, T., & Lumens, J. (2018). Linking cross-bridge cycling kinetics to response to cardiac resynchronization therapy: a multiscale modelling study. EP Europace, 20, 87-93. https://doi.org/10.1093/europace/euy230
    • Dupuis, L. J., Lumens, J., Arts, T., & Delhaas, T. (2018). High tension in sarcomeres hinders myocardial relaxation: A computational study. PLOS ONE, 13(10), Article e0204642. https://doi.org/10.1371/journal.pone.0204642
    • Merken, J., Brunner-La Rocca, H.-P., Weerts, J., Verdonschot, J., Hazebroek, M., Schummers, G., Schreckenberg, M., Lumens, J., Heymans, S., & Knackstedt, C. (2018). Heart Failure With Recovered Ejection Fraction. Journal of the American College of Cardiology, 72(13), 1556-1557. https://doi.org/10.1016/j.jacc.2018.06.070
    • Prinzen, F. W., Dagres, N., Bollmann, A., Arnar, D. O., Bove, S., Camm, J., Casadei, B., Kirchhof, P., Kuck, K.-H., Lumens, J., Michel, M. C., Schwartz, P. J., Van Vleymen, B., Vardas, P., & Hindricks, G. (2018). Innovation in cardiovascular disease in Europe with focus on arrhythmias: current status, opportunities, roadblocks, and the role of multiple stakeholders. EP Europace, 20(5), 733-738. https://doi.org/10.1093/europace/eux095
    • Holmes, J. W., & Lumens, J. (2018). Clinical Applications of Patient-Specific Models: The Case for a Simple Approach. Journal of Cardiovascular Translational Research, 11(2), 71-79. https://doi.org/10.1007/s12265-018-9787-z
    • Huntjens, P. R., Ploux, S., Strik, M., Walmsley, J., Ritter, P., Haissaguerre, M., Prinzen, F. W., Delhaas, T., Lumens, J., & Bordachar, P. (2018). Electrical Substrates Driving Response to Cardiac Resynchronization Therapy: A Combined Clinical–Computational Evaluation. Circulation-Arrhythmia and Electrophysiology, 11(4), Article e005647. https://doi.org/10.1161/CIRCEP.117.005647
  • 2017
    • Walmsley, J., van Everdingen, W., Cramer, M. J., Prinzen, F. W., Delhaas, T., & Lumens, J. (2017). Combining computer modelling and cardiac imaging to understand right ventricular pump function. Cardiovascular Research, 113(12), 1486-1498. https://doi.org/10.1093/cvr/cvx154
    • van Everdingen, W. M., Walmsley, J., Cramer, M. J., van Hagen, I., De Boeck, B. W. L., Meine, M., Delhaas, T., Doevendans, P. A., Prinzen, F. W., Lumens, J., & Leenders, G. E. (2017). Echocardiographic Prediction of Cardiac Resynchronization Therapy Response Requires Analysis of Both Mechanical Dyssynchrony and Right Ventricular Function: A Combined Analysis of Patient Data and Computer Simulations. Journal of the American Society of Echocardiography, 30(10), 1012-1020. https://doi.org/10.1016/j.echo.2017.06.004
    • Gorcsan, J., & Lumens, J. (2017). Rocking and Flashing With RV Pacing Implications for Resynchronization Therapy. JACC-Cardiovascular Imaging, 10(10), 1100-1102. https://doi.org/10.1016/j.jcmg.2016.09.020
    • Janousek, J., Kovanda, J., Lozek, M., Tomek, V., Vojtovic, P., Gebauer, R., Kubus, P., Krejcir, M., Lumens, J., Delhaas, T., & Prinzen, F. (2017). Pulmonary Right Ventricular Resynchronization in Congenital Heart Disease Acute Improvement in Right Ventricular Mechanics and Contraction Efficiency. Circulation-Cardiovascular Imaging, 10(9), Article 006424. https://doi.org/10.1161/CIRCIMAGING.117.006424
    • Jones, S., Lumens, J., Sohaib, S. M. A., Finegold, J. A., Kanagaratnam, P., Tanner, M., Duncan, E., Moore, P., Leyva, F., Frenneaux, M., Mason, M., Hughes, A. D., Francis, D. P., Whinnett, Z. I., & BRAVO Investigators (2017). Cardiac resynchronization therapy: mechanisms of action and scope for further improvement in cardiac function. EP Europace, 19(7), 1178-1186. https://doi.org/10.1093/europace/euw136
    • Derval, N., Duchateau, J., Mahida, S., Eschalier, R., Sacher, F., Lumens, J., Cochet, H., Denis, A., Pillois, X., Yamashita, S., Komatsu, Y., Ploux, S., Amraoui, S., Zemmoura, A., Ritter, P., Hocini, M., Haissaguerre, M., Jais, P., & Bordachar, P. (2017). Distinctive Left Ventricular Activations Associated With ECG Pattern in Heart Failure Patients. Circulation-Arrhythmia and Electrophysiology, 10(6), Article e005073. https://doi.org/10.1161/CIRCEP.117.005073
    • Palau-Caballero, G., Walmsley, J., Van Empel, V., Lumens, J., & Delhaas, T. (2017). Why septal motion is a marker of right ventricular failure in pulmonary arterial hypertension: mechanistic analysis using a computer model. American Journal of Physiology-heart and Circulatory Physiology, 312(4), H691-H700. https://doi.org/10.1152/ajpheart.00596.2016
  • 2016
    • Pluijmert, M., Bovendeerd, P. H. M., Lumens, J., Vernooy, K., Prinzen, F., & Delhaas, T. (2016). New insights from a computational model on the relation between pacing site and CRT response. EP Europace, 18(Suppl_4), iv94–iv103. https://doi.org/10.1093/europace/euw355
    • Mast, T. P., Teske, A. J., Walmsley, J., van der Heijden, J. F., van Es, R., Prinzen, F. W., Delhaas, T., van Veen, T. A., Loh, P., Doevendans, P. A., Cramer, M. J., & Lumens, J. (2016). Right Ventricular Imaging and Computer Simulation for Electromechanical Substrate Characterization in Arrhythmogenic Right Ventricular Cardiomyopathy. Journal of the American College of Cardiology, 68(20), 2185-2197. https://doi.org/10.1016/j.jacc.2016.08.061
    • Palau-Caballero, G., Walmsley, J., Gorcsan, J. III., Lumens, J., & Delhaas, T. (2016). Abnormal Ventricular and Aortic Wall Properties Can Cause Inconsistencies in Grading Aortic Regurgitation Severity: A Computer Simulation Study. Journal of the American Society of Echocardiography, 29(11), 1122-1130.e4. https://doi.org/10.1016/j.echo.2016.07.015
    • Dupuis, L. J., Lumens, J., Arts, T., & Delhaas, T. (2016). Mechano-chemical Interactions in Cardiac Sarcomere Contraction: A Computational Modeling Study. PLoS Computational Biology, 12(10). https://doi.org/10.1371/journal.pcbi.1005126
    • Walmsley, J., Huntjens, P. R., Prinzen, F. W., Delhaas, T., & Lumens, J. (2016). Septal flash and septal rebound stretch have different underlying mechanisms. American Journal of Physiology-heart and Circulatory Physiology, 310(3), H394-H403. https://doi.org/10.1152/ajpheart.00639.2015
  • 2015
    • Lumens, J., Prinzen, F. W., & Delhaas, T. (2015). Longitudinal Strain "Think Globally, Track Locally". JACC-Cardiovascular Imaging, 8(12), 1360-1363. https://doi.org/10.1016/j.jcmg.2015.08.014
    • Lumens, J., Tayal, B., Walmsley, J., Delgado-Montero, A., Huntjens, P. R., Schwartzman, D., Althouse, A. D., Delhaas, T., Prinzen, F. W., & Gorcsan, J. (2015). Differentiating Electromechanical From Non-Electrical Substrates of Mechanical Discoordination to Identify Responders to Cardiac Resynchronization Therapy. Circulation-Cardiovascular Imaging, 8(9), Article e003744. https://doi.org/10.1161/CIRCIMAGING.115.003744
    • Walmsley, J., Arts, T., Derval, N., Bordachar, P., Cochet, H., Ploux, S., Prinzen, F. W., Delhaas, T., & Lumens, J. (2015). Fast Simulation of Mechanical Heterogeneity in the Electrically Asynchronous Heart Using the MultiPatch Module. PLoS Computational Biology, 11(7), Article e1004284. https://doi.org/10.1371/journal.pcbi.1004284
    • Kroon, W., Lumens, J., Potse, M., Suerder, D., Klersy, C., Regoli, F., Murzilli, R., Moccetti, T., Delhaas, T., Krause, R., Prinzen, F. W., & Auricchio, A. (2015). In vivo electromechanical assessment of heart failure patients with prolonged QRS duration. Heart Rhythm, 12(6), 1259-1267. https://doi.org/10.1016/j.hrthm.2015.03.006
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