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MLDS grant Sabine Daemen

MLDS grant Sabine Daemen

15 November 2024

Dr Sabine Daemen (Dept of Internal Medicine) received a Career Development Grant (160k) from the Dutch Digestive Foundation (MLDS).

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Our new Division Leaders

Our new Division Leaders

3 October 2024

As of 1 October 2024, Casper Schalkwijk and Joost Lumens have been appointed as Division Leaders Vessels and Heart. Judith Sluimer will success Hugo ten Cate as Division Leader Blood in March 2025.

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Carim Maastricht
Carim Maastricht

Dominik Linz

Professor

Prof Dominik Linz is a clinician-scientist who received his PhD from Maastricht University, The Netherlands, in 2013 (Prof. U. Schotten) and completed his Cardiology training in Homburg/Saar, Germany, in 2017 (Prof. M. Böhm). In 2017, he was recruited as an Associate Professor and clinical EP-fellow to Adelaide to initiate and drive a translational research programme focussing on atrial fibrillation and sleep disordered breathing at the Royal Adelaide Hospital and University of Adelaide (Prof. P. Sanders). Since 2019, Dr Dominik Linz is a Staff member and consultant clinician at the Heart+Vascular Center, Maastricht UMC+.

Over the past years Prof. Dominik Linz has developed a National and International reputation in the field of cardiac arrhythmia research. The focus of this work has been to understand the pathophysiology and mechanisms underlying atrial arrhythmias and the development of treatment approaches. This research has broadly included: (i) Work describing sleep apnoea associated electrophysiological changes in the atria increasing atrial fibrillation susceptibility. (ii) Description of antiarrhythmic effects of autonomic modulation by renal sympathetic denervation under different pathophysiological conditions. (iii) Work describing the role of the lysosomal carboxypeptidase cathepsin A in the development of an atrial arrhythmogenic substrates. Ongoing research is mainly focused on risk factor modification and preventive interventions for AF.

As of January 2024, Dominik Linz (Department of Cardiology) has been appointed as a professor at Maastricht University. The title of his position is 'Comprehensive Atrial Fibrillation Management.

Dominik-linz

Department of Cardiology

 

  • 2023
    • Linz, D., & Dobrev, D. (2023). Recent highlights on the prevalence and role of sleep disordered breathing in cardiovascular diseases from the International Journal of Cardiology Heart & Vasculature. IJC Heart and Vasculature, 49(1), Article 101287. https://doi.org/10.1016/j.ijcha.2023.101287
    • Baumert, M., Linz, D., Pfeifer, M., Tafelmeier, M., Felfeli, P., Arzt, M., & Shahrbabaki, S. S. (2023). Hypoxaemic burden in heart failure patients receiving adaptive servo-ventilation. Esc heart failure, 10(6), 3725–3728. https://doi.org/10.1002/ehf2.14556
    • Hereijgers, M. J. M., van der Velden, R. M. J., el Moussaoui, N., Verhaert, D. V. M., Habibi, Z., Luermans, J., den Uijl, D., Chaldoupi, S. M., Vernooy, K., Schotten, U., Baumert, M., Gietema, H. A., Mihl, C., Koltowski, L., Franssen, F. M. E., Simons, S. O., & Linz, D. (2023). Repurposing catheter ablation work-up to detect expiratory airflow limitation in patients with atrial fibrillation. IJC Heart and Vasculature, 49(1), Article 101305. https://doi.org/10.1016/j.ijcha.2023.101305
    • Linz, D., & Chaldoupi, S.-M. (2023). Tracking changes in 'healthy sleep' for cardiovascular risk assessment. European Heart Journal, 44(47), 4979-4981. Article ehad509. https://doi.org/10.1093/eurheartj/ehad509
    • Tafelmeier, M., Blagoeva, V. G., Trum, M., Hegner, P., Floerchinger, B., Camboni, D., Creutzenberg, M., Zeman, F., Schmid, C., Maier, L. S., Wagner, S., Linz, D., Baumert, M., & Arzt, M. (2023). Predictors of Nocturnal Hypoxemic Burden in Patients Undergoing Elective Coronary Artery Bypass Grafting Surgery. Biomedicines, 11(10), Article 2665. https://doi.org/10.3390/biomedicines11102665
    • Baumert, M., Linz, D., McKane, S., & Immanuel, S. (2023). Transvenous phrenic nerve stimulation is associated with normalization of nocturnal heart rate perturbations in patients with central sleep apnea. Sleep (Online), 46(9), Article zsad166. https://doi.org/10.1093/sleep/zsad166
    • Frausing, M. H. J. P., van de Lande, M. E., Maass, A. H., Nguyen, B. O., Hemels, M. E. W., Tieleman, R. G., Koldenhof, T., De Melis, M., Linz, D., Schotten, U., Weberndoerfer, V., Crijns, H. J. G. M., Van Gelder, I. C., Nielsen, J. C., & Rienstra, M. (2023). Brady- and tachyarrhythmias detected by continuous rhythm monitoring in paroxysmal atrial fibrillation. Heart, 109(17), 1286-1293. https://doi.org/10.1136/heartjnl-2022-322253
    • Shahrbabaki, S. S., Linz, D., & Baumert, M. (2023). Nocturnal pulse wave amplitude attenuations are associated with long-term cardiovascular events. International Journal of Cardiology, 385(1), 55-61. https://doi.org/10.1016/j.ijcard.2023.05.047
    • Linz, D., Chun, J., Guerra, F., Conte, G., Garcia, R., Kommata, V., Malaczynska-Rajpold, K., Nesti, M., & Duncker, D. (2023). Electrophysiology fellowship experience and requirements: an EHRA survey. EP Europace, 25(9), 1-7. Article euad249. https://doi.org/10.1093/europace/euad249
    • Varma, N., Braunschweig, F., Burri, H., Hindricks, G., Linz, D., Michowitz, Y., Ricci, R. P., & Nielsen, J. C. (2023). Remote monitoring of cardiac implantable electronic devices and disease management. EP Europace, 25(9), Article euad233. https://doi.org/10.1093/europace/euad233
    • Gawalko, M., Linz, D., & Dobrev, D. (2023). Does weight matter in cryoballoon ablation?IJC Heart and Vasculature, 47(1), Article 101251. https://doi.org/10.1016/j.ijcha.2023.101251
    • Hendriks, J. M., Lee, G., & Linz, D. (2023). Sleeping Beauty unravelled: Detection of sleep apnoea in patients with atrial fibrillation. IJC Heart and Vasculature, 47(1), Article 101237. https://doi.org/10.1016/j.ijcha.2023.101237
    • Verhaert, D. V. M., Linz, D., Wassink, G. F., Weijs, B., Philippens, S., Luermans, J. G. L. M., Westra, S. W., Schotten, U., Vernooy, K., & den Uijl, D. W. (2023). A new efficient and integrated pathway for patient evaluation prior to atrial fibrillation ablation. European Journal of Cardiovascular Nursing, 22(5), 498-505. https://doi.org/10.1093/eurjcn/zvac095
    • van Mourik, M. J. W., Linz, D., Verwijs, H. J. A., Bekkers, S. C. A. M., Weerts, J., Schotten, U., Rocca, H. B.-L., Lumens, J., Crijns, H. J. G. M., Weijs, B., & Knackstedt, C. (2023). Evaluating subclinical left ventricular and left atrial dysfunction in idiopathic atrial fibrillation: A speckle-tracking based strain-analysis. International Journal of Cardiology, 383(1), 159-165. https://doi.org/10.1016/j.ijcard.2023.04.024
    • Tilz, R. R., Schmidt, V., Pürerfellner, H., Maury, P., Chun, K. J., Martinek, M., Sohns, C., Schmidt, B., Mandel, F., Gandjbakhch, E., Laredo, M., Gunawardene, M. A., Willems, S., Beiert, T., Borlich, M., Iden, L., Füting, A., Spittler, R., Gaspar, T., ... Author collaboration (2023). A worldwide survey on incidence, management and prognosis of oesophageal fistula formation following atrial fibrillation catheter ablation: The POTTER-AF study. European Heart Journal, 44(27), 2458-2469. https://doi.org/10.1093/eurheartj/ehad250
    • van der Velden, R. M. J., Hereijgers, M. J. M., Arman, N., van Middendorp, N., Franssen, F. M. E., Gawalko, M., Verhaert, D. V. M., Habibi, Z., Vernooy, K., Koltowski, L., Hendriks, J. M., Heidbuchel, H., Desteghe, L., Simons, S. O., & Linz, D. (2023). Implementation of a screening and management pathway for chronic obstructive pulmonary disease in patients with atrial fibrillation. EP Europace, 25(7), 1-10. Article euad193. https://doi.org/10.1093/europace/euad193
    • Tu, S. J., Gallagher, C., Elliott, A. D., Bradbury, K. E., Marcus, G. M., Linz, D., Pitman, B. M., Middeldorp, M. E., Hendriks, J. M., Lau, D. H., Sanders, P., & Wong, C. X. (2023). Associations of dietary patterns, ultra-processed food and nutrient intake with incident atrial fibrillation. Heart, 109(22), 1683–1689. https://doi.org/10.1136/heartjnl-2023-322412
    • Manninger, M., Hermans, A. N. L., Caracioni, A.-A., Rohrer, U., Eberl, A.-S., Vernooy, K., Zirlik, A., Linz, D., & Scherr, D. (2023). Photoplethysmography-documented atrial fibrillation in the first week after catheter ablation is associated with lower success rates. Frontiers in Cardiovascular Medicine, 10(1), Article 1199630. https://doi.org/10.3389/fcvm.2023.1199630
    • Rijks, J. H. J., Lankveld, T., Manusama, R., Broers, B., van Stipdonk, A. M. W., Chaldoupi, S. M., ter Bekke, R. M. A., Schotten, U., Linz, D., Luermans, J. G. L. M., & Vernooy, K. (2023). Left Bundle Branch Area Pacing and Atrioventricular Node Ablation in a Single-Procedure Approach for Elderly Patients with Symptomatic Atrial Fibrillation. Journal of Clinical Medicine, 12(12), Article 4028. https://doi.org/10.3390/jcm12124028
    • Betz, K., Verhaert, D. V. M., Gawalko, M., Hermans, A. N. L., Habibi, Z., Pluymaekers, N. A. H. A., van der Velden, R. M. J., Homberg, M., Philippens, S., Hereijgers, M. J. M., Vorstermans, B., Simons, S. O., den Uijl, D. W., Chaldoupi, S. M., Luermans, J. G. L. M., Westra, S. W., Lankveld, T., van Steenwijk, R. P., Hol, B., ... Linz, D. (2023). Atrial fibrillation-specific refinement of the STOP-Bang sleep apnoea screening questionnaire: insights from the Virtual-SAFARI study. Clinical research in cardiology, 112(6), 834-845. https://doi.org/10.1007/s00392-023-02157-9
    • Isaksen, J. L., Manninger, M., & Linz, D. (2023). The right modality for the right pulmonary vein shape in ablation for atrial fibrillation. Journal of Interventional Cardiac Electrophysiology, 66(4), 827-828. https://doi.org/10.1007/s10840-022-01390-y
    • Gawałko, M., Hermans, A. N., van der Velden, R. M., Betz, K., Vm Verhaert, D., Hillmann, H. A., Scherr, D., Meier, J., Sultan, A., Steven, D., Terentieva, E., Pisters, R., Hemels, M., Voorhout, L., Lodziński, P., Krzowski, B., Gupta, D., Kozhuharov, N., Pison, L., ... Hendriks, J. M. (2023). Patient motivation and adherence to an on-demand app-based heart rate and rhythm monitoring for atrial fibrillation management: data from the TeleCheck-AF project. European Journal of Cardiovascular Nursing, 22(4), 412-424. https://doi.org/10.1093/eurjcn/zvac061
    • van de Lande, M. E., Rama, R. S., Koldenhof, T., Arita, V. A., Nguyen, B. O., van Deutekom, C., Weberndorfer, V., Crijns, H. J. G. M., Hemels, M. E. W., Tieleman, R. G., de Melis, M., Schotten, U., Linz, D., Van Gelder, I. C., Rienstra, M., & RACE V Investigators (2023). Time of onset of atrial fibrillation and atrial fibrillation progression data from the RACE V study. EP Europace, 25(5), Article euad058. https://doi.org/10.1093/europace/euad058
    • Palmu, J., Boerschel, C. S., Ortega-Alonso, A., Marko, L., Inouye, M., Jousilahti, P., Salido, R. A., Sanders, K., Brennan, C., Humphrey, G. C., Sanders, J. G., Gutmann, F., Linz, D., Salomaa, V., Havulinna, A. S., Forslund, S. K., Knight, R., Lahti, L., Niiranen, T., & Schnabel, R. B. (2023). Gut microbiome and atrial fibrillation-results from a large population-based study. EBioMedicine, 91(1), Article 104583. https://doi.org/10.1016/j.ebiom.2023.104583
    • Hereijgers, M. J. M., van der Velden, R. M. J., Simons, S., & Linz, D. (2023). Respiratory Function Assessment in Patients With Atrial Fibrillation: A Needed Extension of Combined Comorbidity Management?Canadian Journal of Cardiology, 39(5), 623-624. https://doi.org/10.1016/j.cjca.2023.02.006
    • Baumert, M., Immanuel, S., McKane, S., & Linz, D. (2023). Transvenous phrenic nerve stimulation for the treatment of central sleep apnea reduces episodic hypoxemic burden. International Journal of Cardiology, 378(1), 89-95. https://doi.org/10.1016/j.ijcard.2023.02.041
    • Leao, S., Luermans, J., Vernooy, K., ter Bekke, R., den Uijl, D., Linz, D., & Chaldoupi, S.-M. (2023). The great deceiver: a case series of 'double fire' atrioventricular nodal response. European Heart Journal - Case Reports, 7(4), Article ytad162. https://doi.org/10.1093/ehjcr/ytad162
    • Arita, V. A., Van de Lande, M. E., Ekrami, N. K., Nguyen, B. O., Van Melle, J. M., Geelhoed, B., De With, R. R., Weberndorfer, V., Erkuner, O., Hillege, H., Linz, D., Ten Cate, H., Spronk, H. M. H., Koldenhof, T., Tieleman, R. G., Schotten, U., Crijns, H. J. G. M., Van Gelder, I. C., & Rienstra, M. (2023). Clinical utility of the 4S-AF scheme in predicting progression of atrial fibrillation: data from the RACE V study. EP Europace, 25(4), 1323-1331. https://doi.org/10.1093/europace/euac268
    • Hermans, A. N. L., Betz, K., Verhaert, D. V. M., den Uijl, D. W., Clerx, K., Debie, L., Lahaije, M., Vernooy, K., Linz, D., & Weijs, B. (2023). 360° Virtual reality to improve patient education and reduce anxiety towards atrial fibrillation ablation. EP Europace, 25(3), 855-862. https://doi.org/10.1093/europace/euac246
    • Hermans, A. N. L., Isaksen, J. L., Gawalko, M., Pluymaekers, N. A. H. A., van der Velden, R. M. J., Snippe, H., Evens, S., De Witte, G., Luermans, J. G. L. M., Manninger, M., Lumens, J., Kanters, J. K., & Linz, D. (2023). Accuracy of continuous photoplethysmography-based 1 min mean heart rate assessment during atrial fibrillation. EP Europace, 25(3), 835-844. https://doi.org/10.1093/europace/euad011
    • Hertel, J. N., Jerltorp, K., Hansen, M. E. H., Isaksen, J. L., Sattler, S. M., Linz, B., Chaldoupi, S. M., Jespersen, T., Saljic, A., Gang, U. F., Manninger, M., & Linz, D. (2023). 3D-electroanatomical mapping of the left atrium and catheter-based pulmonary vein isolation in pigs: A practical guide. Frontiers in Cardiovascular Medicine, 10(1), Article 1139364. https://doi.org/10.3389/fcvm.2023.1139364
    • Rahm, A. K., Linz, D., & Gang, U. J. O. (2023). Imaging approaches for pulmonary vein isolation in patients after lobectomy or pneumonectomy: a case series. European Heart Journal - Case Reports, 7(3), Article ytad117. https://doi.org/10.1093/ehjcr/ytad117
    • Linz, D., & Chaldoupi, S. M. (2023). Alcohol Abstinence Around Atrial Fibrillation Ablation: Breaking Common Habits. Canadian Journal of Cardiology, 39(3), 274-276. https://doi.org/10.1016/j.cjca.2023.01.006
    • Hillmann, H. A. K., Betz, K., Linz, D., & Duncker, D. (2023). How to: Antiarrhythmika in der klinischen Anwendung. Herzschrittmachertherapie und Elektrophysiologie, 34(1), 82-90. https://doi.org/10.1007/s00399-022-00919-y
    • Gawalko, M., Saljic, A., Li, N., Abu-Taha, I., Jespersen, T., Linz, D., Nattel, S., Heijman, J., Fender, A., & Dobrev, D. (2023). Adiposity-associated atrial fibrillation: molecular determinants, mechanisms, and clinical significance. Cardiovascular Research, 119(3), 614-630. https://doi.org/10.1093/cvr/cvac093
    • Gawałko, M., & Linz, D. (2023). Atrial Fibrillation Detection and Management in Hypertension. Hypertension, 80(3), 523-533. https://doi.org/10.1161/HYPERTENSIONAHA.122.19459
    • Linz, D., & Schnabel, R. B. (2023). Gut microbiota-derived metabolites in atrial fibrillation: risk markers or modifiable risk factors?Heart, 109(5), 342-343. https://doi.org/10.1136/heartjnl-2022-321806
    • Warming, P. E., Garcia, R., Hansen, C. J., Simons, S. O., Torp-Pedersen, C., Linz, D., & Tfelt-Hansen, J. (2023). The association of temporal sequence in atrial fibrillation and chronic obstructive pulmonary disease diagnosis and mortality risk: Reply. European heart journal - Quality of care & clinical outcomes, 9(2), E2-E2. https://doi.org/10.1093/ehjqcco/qcac079
    • Warming, P. E., Garcia, R., Hansen, C. J., Simons, S. O., Torp-Pedersen, C., Linz, D., & Tfelt-Hansen, J. (2023). Atrial fibrillation and chronic obstructive pulmonary disease: diagnostic sequence and mortality risk. European heart journal - Quality of care & clinical outcomes, 9(2), 128-134. Article qcac059. https://doi.org/10.1093/ehjqcco/qcac059
    • Leao, S., Linz, D., & Luermans, J. (2023). Accessory pathway ablation: microelectrodes reveal the hidden signals. EP Europace, 25(2), 432. https://doi.org/10.1093/europace/euac271
    • Nguyen, B. O., Weberndorfer, V., Crijns, H. J. G. M., Geelhoed, B., Ten Cate, H., Spronk, H., Kroon, A., De With, R., Al-Jazairi, M., Maass, A. H., Blaauw, Y., Tieleman, R. G., Hemels, M. E. W., Luermans, J., de Groot, J., Allaart, C. P., Elvan, A., De Melis, M., Scheerder, C., ... Rienstra, M. (2023). Prevalence and determinants of atrial fibrillation progression in paroxysmal atrial fibrillation. Heart, 109(3), 186-194. https://doi.org/10.1136/heartjnl-2022-321027
    • Shahrbabaki, S. S., Linz, D., Redline, S., Stone, K., Ensrud, K., & Baumert, M. (2023). Sleep Arousal-Related Ventricular Repolarization Lability Is Associated With Cardiovascular Mortality in Older Community-Dwelling Men. Chest, 163(2), 419-432. https://doi.org/10.1016/j.chest.2022.09.043
    • Luker, J., Strik, M., Andrade, J. G., Raymond-Paquin, A., Elrefai, M. H., Roberts, P. R., Perez, O. C., Kron, J., Koneru, J., Franqui-Rivera, H., Sultan, A., Ernst, A., Schmitt, J., Pott, A., Veltmann, C., Srinivasan, N. T., Collinson, J., van Stipdonk, A. M. W., Linz, D., ... Steven, D. (2023). Incidence of premature battery depletion in subcutaneous cardioverter-defibrillator patients: insights from a multicenter registry. Journal of Interventional Cardiac Electrophysiology. Advance online publication. https://doi.org/10.1007/s10840-023-01468-1
    • Schnabel, R. B., Marinelli, E. A., Arbelo, E., Boriani, G., Boveda, S., Buckley, C. M., Camm, A. J., Casadei, B., Chua, W., Dagres, N., de Melis, M., Desteghe, L., Diederichsen, S. Z., Duncker, D., Eckardt, L., Eisert, C., Engler, D., Fabritz, L., Freedman, B., ... Kirchhof, P. (2023). Early diagnosis and better rhythm management to improve outcomes in patients with atrial fibrillation: the 8th AFNET/EHRA consensus conference. EP Europace, 25(1), 6–27. https://doi.org/10.1093/europace/euac062
    • van der Velden, R. M. J., Pluymaekers, N. A. H. A., Dudink, E. A. M. P., Luermans, J. G. L. M., Meeder, J. G., Heesen, W. F., Lenderink, T., Widdershoven, J. W. M. G., Bucx, J. J. J., Rienstra, M., Kamp, O., van Opstal, J. M., Kirchhof, C. J. H. J., van Dijk, V. F., Swart, H. P., Alings, M., Van Gelder, I. C., Crijns, H. J. G. M., & Linz, D. (2023). Mobile health adherence for the detection of recurrent recent-onset atrial fibrillation. Heart, 109(1), 26-33. https://doi.org/10.1136/heartjnl-2022-321346
    • Linz, B., Hesselkilde, E. M., Skarsfeldt, M. A., Hertel, J. N., Sattler, S. M., Yan, Y., Tfelt-Hansen, J., Diness, J. G., Bentzen, B. H., Linz, D., & Jespersen, T. (2023). Pharmacological inhibition of SK-channels with AP14145 prevents atrial arrhythmogenic changes in a porcine model for obstructive respiratory events. Journal of Cardiovascular Electrophysiology, 34(1), 126-134. https://doi.org/10.1111/jce.15769
  • 2022
    • Baumert, M., Linz, D., & Arzt, M. (2022). Modeling sleep-disordered breathing using overnight polysomnography-opportunities for patient-oriented research and patient care. Sleep (Online), 45(12), Article zsac213. https://doi.org/10.1093/sleep/zsac213
    • Baumert, M., Cowie, M. R., Redline, S., Mehra, R., Arzt, M., Pépin, J.-L., & Linz, D. (2022). Sleep characterization with smart wearable devices: A call for standardization and consensus recommendations. Sleep (Online), 45(12), Article zsac183. https://doi.org/10.1093/sleep/zsac183
    • Hermans, B. J. M., Weberndörfer, V., Bijvoet, G. P., Chaldoupi, S.-M., & Linz, D. (2022). New concepts in atrial fibrillation pathophysiology. Herzschrittmachertherapie und Elektrophysiologie, 33, 362-366. https://doi.org/10.1007/s00399-022-00897-1
    • Boriani, G., Svennberg, E., Guerra, F., Linz, D., Casado-Arroyo, R., Malaczynska-Rajpold, K., Duncker, D., Boveda, S., Merino, J. L., & Leclercq, C. (2022). Reimbursement practices for use of digital devices in atrial fibrillation and other arrhythmias: a European Heart Rhythm Association survey. EP Europace, 24(11), 1834-1843. https://doi.org/10.1093/europace/euac142
Overview