• 2022
    • Iding, A. F. J., & Ten Cate-Hoek, A. J. (2022). How to optimize the prevention of post‑thrombotic syndrome: recent advances. Polskie Archiwum Medycyny Wewnetrznej-Polish Archives of Internal Medicine, 132(7-8), Article 16288. https://doi.org/10.20452/pamw.16288
    • Blanas, A., Karsjens, H., de Ligt, A., Huijbers, E. J. M., van Loon, K., Denisov, S., Durukan, C., Engbersen, D., Groen, J., Hennig, S., Hackeng, T., van Beijnum, J. R., & Griffioen, A. W. (2022). Vaccination with a bacterial peptide conjugated to SARS-CoV-2 receptor-binding domain accelerates immunity and protects against COVID-19. iScience, 25(8), Article 104719. https://doi.org/10.1016/j.isci.2022.104719
    • Pavlic, A., Bahram Sangani, N., Kerins, J., Nicolaes, G., Schurgers, L., & Reutelingsperger, C. (2022). Vascular Smooth Muscle Cell Neutral Sphingomyelinase 2 in the Release of Exosomes and Vascular Calcification. International journal of molecular sciences, 23(16), Article 9178. https://doi.org/10.3390/ijms23169178
    • Heines, S. J. H., de Jongh, S. A. M., Strauch, U., van der Horst, I. C. C., van de Poll, M. C. G., & Bergmans, D. C. J. J. (2022). The global inhomogeneity index assessed by electrical impedance tomography overestimates PEEP requirement in patients with ARDS: an observational study. BMC Anesthesiology, 22(1), Article 258. https://doi.org/10.1186/s12871-022-01801-7
    • Schreurs, R. H. P., Joore, M. A., De Bruijn-Geraets, D. P., Ten Cate, H., & Ten Cate-Hoek, A. J. (2022). A realist evaluation to identify targets to improve the organization of compression therapy for deep venous thrombosis- and chronic venous disease patients. PLOS ONE, 17(8), Article e0272566. https://doi.org/10.1371/journal.pone.0272566
    • Huang, J., Jooss, N. J., Fernández, D. I., Sickmann, A., García, Á., Wichapong, K., Dijkgraaf, I., & Heemskerk, J. W. M. (2022). Roles of Focal Adhesion Kinase PTK2 and Integrin αIIbβ3 Signaling in Collagen- and GPVI-Dependent Thrombus Formation under Shear. International journal of molecular sciences, 23(15), Article 8688. https://doi.org/10.3390/ijms23158688
    • Navarro, S., Starke, A., Heemskerk, J. W. M., Kuijpers, M. J. E., Stegner, D., & Nieswandt, B. (2022). Targeting of a Conserved Epitope in Mouse and Human GPVI Differently Affects Receptor Function. International journal of molecular sciences, 23(15), Article 8610. https://doi.org/10.3390/ijms23158610
    • Camm, C. F., Virdone, S., Goto, S., Bassand, J. P., van Eickels, M., Haas, S., Gersh, B. J., Pieper, K., Fox, K. A. A., Misselwitz, F., Turpie, A. G. G., Goldhaber, S. Z., Verheugt, F., Camm, J., Kayani, G., Panchenko, E., Oh, S., Luciardi, H. L., Sawhney, J. P. S., ... GARFIELD-AF Investigators (2022). Association of body mass index with outcomes in patients with newly diagnosed atrial fibrillation: GARFIELD-AF. Open Heart, 9(2), Article e002038. https://doi.org/10.1136/openhrt-2022-002038
    • Willems, L. H., Maas, D. P. M. S. M., Kramers, K., Reijnen, M. M. P. J., Riksen, N. P., Ten Cate, H., van der Vijver-Coppen, R. J., de Borst, G. J., Mees, B. M. W., Zeebregts, C. J., Hannink, G., & Warlé, M. C. (2022). Antithrombotic Therapy for Symptomatic Peripheral Arterial Disease: A Systematic Review and Network Meta-Analysis. Drugs, 82(12), 1287-1302. https://doi.org/10.1007/s40265-022-01756-6
    • Falanga, A., Leader, A., Ambaglio, C., Bagoly, Z., Castaman, G., Elalamy, I., Lecumberri, R., Niessner, A., Pabinger, I., Szmit, S., Trinchero, A., Ten Cate, H., & Rocca, B. (2022). EHA Guidelines on Management of Antithrombotic Treatments in Thrombocytopenic Patients With Cancer. HemaSphere, 6(8), e750. Article e750. https://doi.org/10.1097/HS9.0000000000000750
    • Brouwers, M. C. G. J., Simons, N., Kooi, M. E., de Ritter, R., van Dongen, M. C. J. M., Eussen, S. J. P. M., Bekers, O., Kooman, J., van Greevenbroek, M. M. J., van der Kallen, C. J. H., Schram, M. T., Schaper, N. C., Schalkwijk, C. G., & Stehouwer, C. D. A. (2022). Intrahepatic lipid content is independently associated with soluble E-selectin levels: The Maastricht study. Digestive and Liver Disease, 54(8), 1038-1043. https://doi.org/10.1016/j.dld.2022.01.130
    • Jooss, N. J., Smith, C. W., Pike, J. A., Farndale, R. W., Henskens, Y. M. C., Watson, S. P., Heemskerk, J. W. M., & Poulter, N. S. (2022). Platelet glycoprotein VI cluster size is related to thrombus formation and phosphatidylserine exposure in collagen-adherent platelets under arterial shear. Journal of Thrombosis and Haemostasis, 21(8), 2260-2267. https://doi.org/10.1016/j.jtha.2023.04.028
    • de Laat, B., Stragier, H., de Laat-Kremers, R., Ninivaggi, M., Mesotten, D., Thiessen, S., Van Pelt, K., Roest, M., Penders, J., Vanelderen, P., Huskens, D., De Jongh, R., Vander Laenen, M., Fivez, T., ten Cate, H., Heylen, R., Heylen, L., & Steensels, D. (2022). Population-wide persistent hemostatic changes after vaccination with ChAdOx1-S. Frontiers in Cardiovascular Medicine, 9, Article 966028. https://doi.org/10.3389/fcvm.2022.966028
    • Janssen, E. B. N. J., Hooijschuur, M. C. E., Lopes van Balen, V. A., Morina-Shijaku, E., Spaan, J. J., Mulder, E. G., Hoeks, A. P., Reesink, K. D., van Kuijk, S. M. J., Van't Hof, A., van Bussel, B. C. T., Spaanderman, M. E. A., & Ghossein-Doha, C. (2022). No accelerated arterial aging in relatively young women after preeclampsia as compared to normotensive pregnancy. Frontiers in Cardiovascular Medicine, 9, Article 911603. https://doi.org/10.3389/fcvm.2022.911603
    • Nagy, M., & ten Cate, H. (2022). What to expect from drug targeting factor XI?Cardiovascular Research, 118(10), E72-E74. https://doi.org/10.1093/cvr/cvac091
    • Veninga, A., Handtke, S., Aurich, K., Tullemans, B., Brouns, S., Schwarz, S. L., Heubel-Moenen, F. C., Greinacher, A., Heemskerk, J. W. M., van der Meijden, P., & Thiele, T. (2022). GPVI expression is linked to platelet size, age, and reactivity. Blood advances, 6(14), 4162-4173. https://doi.org/10.1182/bloodadvances.2021006904
    • Carlo, A., Yan, Q., Ten Cate, H., De Laat-Kremers, R., De Laat, B., & Ninivaggi, M. (2022). Semi-automated thrombin dynamics applying the ST Genesia thrombin generation assay. Frontiers in Cardiovascular Medicine, 9, Article 912433. https://doi.org/10.3389/fcvm.2022.912433
    • Bochenek, M. L., Gogiraju, R., Grossmann, S., Krug, J., Orth, J., Reyda, S., Georgiadis, G. S., Spronk, H. M., Konstantinides, S., Munzel, T., Griffin, J. H., Wild, P., Espinola-Klein, C., Ruf, W., & Schafer, K. (2022). EPCR-PAR1 biased signaling regulates perfusion recovery and neovascularization in peripheral ischemia. JCI INSIGHT, 7(14), Article e157701. https://doi.org/10.1172/jci.insight.157701
    • Spoormans, E. M., Lemkes, J. S., Janssens, G. N., Soultana, O., van der Hoeven, N. W., Jewbali, L. S. D., Dubois, E. A., Meuwissen, M., Rijpstra, T. A., Bosker, H. A., Blans, M. J., Bleeker, G. B., Baak, R., Vlachojannis, G. J., Eikemans, B. J. W., van der Harst, P., van der Horst, I. C. C., Voskuil, M., van der Heijden, J. J., ... van Royen, N. (2022). Ischaemic electrocardiogram patterns and its association with survival in out-of-hospital cardiac arrest patients without ST-segment elevation myocardial infarction: a COACT trials' post-hoc subgroup analysis. European Heart Journal: Acute Cardiovascular Care, 11(7), 535-543. https://doi.org/10.1093/ehjacc/zuac060
    • Winckers, K., & Ten Cate, H. (2022). Tromboseprofylaxe anno 2022: tijd voor pillen?Nederlands Tijdschrift voor Geneeskunde, 166, Article D6882. https://www.ntvg.nl/artikelen/tromboseprofylaxe-anno-2022-tijd-voor-pillen#auteursinformatie
    • Eck, R. J., Elling, T., Sutton, A. J., Wetterslev, J., Gluud, C., van der Horst, I. C. C., Gans, R. O. B., Meijer, K., & Keus, F. (2022). Anticoagulants for thrombosis prophylaxis in acutely ill patients admitted to hospital: systematic review and network meta-analysis. BMJ, 378, Article e070022. https://doi.org/10.1136/bmj-2022-070022
    • Tas, J., Eleveld, N., Borg, M., Bos, K. D. J., Langermans, A. P., van Kuijk, S. M. J., van der Horst, I. C. C., Elting, J. W. J., & Aries, M. J. H. (2022). Cerebral Autoregulation Assessment Using the Near Infrared Spectroscopy 'NIRS-Only' High Frequency Methodology in Critically Ill Patients: A Prospective Cross-Sectional Study. Cells, 11(14), Article 2254. https://doi.org/10.3390/cells11142254
    • Bistervels, I. M., Bavalia, R., Beyer-Westendorf, J., ten Cate-Hoek, A. J., Schellong, S. M., Kovacs, M. J., Falvo, N., Meijer, K., Stephan, D., Boersma, W. G., ten Wolde, M., Couturaud, F., Verhamme, P., Brisot, D., Kahn, S. R., Ghanima, W., Montaclair, K., Hugman, A., Carroll, P., ... Hokusai PTS Investigators (2022). Postthrombotic syndrome and quality of life after deep vein thrombosis in patients treated with edoxaban versus warfarin. Research and practice in thrombosis and haemostasis, 6(5), Article e12748. https://doi.org/10.1002/rth2.12748
    • Sedzro, J. C., Adam, F., Auditeau, C., Bianchini, E., De Carvalho, A., Peyron, I., Daramé, S., Gandrille, S., Thomassen, S., Hackeng, T. M., Christophe, O. D., Lenting, P. J., Denis, C. V., Borgel, D., & Saller, F. (2022). Antithrombotic potential of a single-domain antibody enhancing the activated protein C-cofactor activity of protein S. Journal of Thrombosis and Haemostasis, 20(7), 1653-1664. https://doi.org/10.1111/jth.15736
    • Raafs, A. G., Ghossein, M. A., Brandt, Y., Henkens, M. T. H. M., Kooi, M. E., Vernooy, K., Spaanderman, M. E. A., Gerretsen, S., van Santen, S., Driessen, R. G. H., Knackstedt, C., van der Horst, I. C. C., van Bussel, B. C. T., Heymans, S. R. B., Ghossein-Doha, C., & MaastrICCht Collaborators (2022). Cardiovascular outcome 6 months after severe coronavirus disease 2019 infection. Journal of Hypertension, 40(7), 1278-1287. https://doi.org/10.1097/hjh.0000000000003110
    • Arnoldussen, C. W. K. P., Notten, P., Brans, R., Vroegindeweij, D., Tick, L. W., van de Poel, M. H. W., Wikkeling, O. R. M., Vleming, L. J., Koster, A., Jie, K. S. G., Jacobs, E. M. G., Planken, N., Wittens, C. H. A., ten Cate, H., Wildberger, J. E., & ten Cate-Hoek, A. J. (2022). Clinical impact of assessing thrombus age using magnetic resonance venography prior to catheter-directed thrombolysis. European Radiology, 32(7), 4555-4564. https://doi.org/10.1007/s00330-022-08599-5
    • Martens, B., Driessen, R. G. H., Brandts, L., Hoitinga, P., van Veen, F., Driessen, M., Weberndörfer, V., Kietselaer, B., Ghossein-Doha, C., Gietema, H. A., Vernooy, K., van der Horst, I. C. C., Wildberger, J. E., van Bussel, B. C. T., Mihl, C., & MaastrICCht Collaborators (2022). Coronary Artery Calcifications Are Associated With More Severe Multiorgan Failure in Patients With Severe Coronavirus Disease 2019 Infection: Longitudinal Results of the Maastricht Intensive Care COVID Cohort. Journal of Thoracic Imaging, 37(4), 217-224. https://doi.org/10.1097/RTI.0000000000000648
    • Gorog, D. A., Storey, R. F., Gurbel, P. A., Tantry, U. S., Berger, J. S., Chan, M. Y., Duerschmied, D., Smyth, S. S., Parker, W. A. E., Ajjan, R. A., Vilahur, G., Badimon, L., ten Berg, J. M., ten Cate, H., Peyvandi, F., Wang, T. T., & Becker, R. C. (2022). Current and novel biomarkers of thrombotic risk in COVID-19: a Consensus Statement from the International COVID-19 Thrombosis Biomarkers Colloquium. Nature Reviews Cardiology, 19(7), 475-495. https://doi.org/10.1038/s41569-021-00665-7
    • Bor, W. L., de Veer, A. J. W., Olie, R. H., Rikken, S. A. O. F., Chan Pin Yin, D. R. P. P., Herrman, J. P. R., Vrolix, M., Meuwissen, M., Vandendriessche, T., van Mieghem, C., Magro, M., Bennaghmouch, N., Hermanides, R., Adriaenssens, T., Dewilde, W. J. M., & Ten Berg, J. M. (2022). Dual versus triple antithrombotic therapy after percutaneous coronary intervention: the prospective multicentre WOEST 2 Study. Eurointervention, 18(4), e303-e313. https://doi.org/10.4244/eij-d-21-00703
    • Aarnink, E. W., Huijboom, M. F. M., Bor, W. L., Maarse, M., Zheng, K. L., Ten Cate, H., Ten Berg, J. M., & Boersma, L. V. A. (2022). Hemostatic biomarkers and antithrombotic strategy in percutaneous left atrial interventions: State-of-the-art review. Thrombosis Research, 215, 41-51. https://doi.org/10.1016/j.thromres.2022.05.009
    • Duim, S. N., Vlasveld, L. T., Mezger, S. T. P., Mingels, A. M. A., Ramakers, C. R. B., De Boer, D., Heil, S. G., Nexo, E., & Van Rossum, A. P. (2022). "Macro transcobalamin causing raised vitamin B12: Case-based laboratory investigation". Annals of Clinical Biochemistry, 59(4), 302-307. Article 00045632221087132. https://doi.org/10.1177/00045632221087132
    • Cuijpers, A. C. M., Coolsen, M. M. E., Schnabel, R. M., Lubbers, T., van der Horst, I. C. C., van Santen, S., Damink, S. W. M. O., & van de Poll, M. C. G. (2022). Self-perceived recovery and quality of life in elderly patients surviving ICU-admission for abdominal sepsis. Journal of Intensive Care Medicine, 37(7), 970-978. Article 08850666211052460. https://doi.org/10.1177/08850666211052460
    • Mariani, S., De Piero, M. E., Ravaux, J. M., Saelmans, A., Kawczynski, M. J., van Bussel, B. C. T., Di Mauro, M., Willers, A., Swol, J., Kowalewski, M., Li, T., Delnoij, T. S. R., van der Horst, I. C. C., Maessen, J., & Lorusso, R. (2022). Temporary mechanical circulatory support for COVID-19 patients: A systematic review of literature. Artificial Organs, 46(7), 1249-1267. https://doi.org/10.1111/aor.14261
    • Verhaert, D. V. M., Linz, D., Chaldoupi, S. M., Westra, S. W., den Uijl, D. W., Philippens, S., Kerperien, M., Habibi, Z., Vorstermans, B., ter Bekke, R. M. A., Beukema, R. J., Evertz, R., Hemels, M. E. W., Luermans, J. G. L. M., Manusama, R., Lankveld, T. A. R., van der Heijden, C. A. J., Bidar, E., Hermans, B. M., ... Schotten, U. (2022). Rationale and Design of the ISOLATION Study: A Multicenter Prospective Cohort Study Identifying Predictors for Successful Atrial Fibrillation Ablation in an Integrated Clinical Care and Research Pathway. Frontiers in Cardiovascular Medicine, 9, Article 879139. https://doi.org/10.3389/fcvm.2022.879139
    • Cox, E. G. M., Koeze, J., van der Horst, I. C. C., & Wiersema, R. (2022). Calculated left ventricular outflow tract diameter for critically ill patients. Journal of Intensive Care, 10(1), Article 31. https://doi.org/10.1186/s40560-022-00623-6
    • Karel, M. F. A., Roosen, M. G. C. H., Tullemans, B. M. E., Zhang, C. E., Staals, J., Cosemans, J. M. E. M., & Koenen, R. R. (2022). Characterization of cerebral small vessel disease by neutrophil and platelet activation markers using artificial intelligence. Journal of Neuroimmunology, 367, Article 577863. https://doi.org/10.1016/j.jneuroim.2022.577863
    • Robles, A. P., ten Cate, V., Schulz, A., Prochaska, J. H., Rapp, S., Koeck, T., Panova-Noeva, M., Heitmeier, S., Schwers, S., Leineweber, K., Seyfarth, H. J., Opitz, C. F., Spronk, H., Espinola-Klein, C., Lackner, K. J., Munzel, T., Andrade-Navarro, M. A., Konstantinides, S. V., ten Cate, H., & Wild, P. S. (2022). Association of FXI activity with thrombo-inflammation, extracellular matrix, lipid metabolism and apoptosis in venous thrombosis. Scientific Reports, 12(1), Article 9761. https://doi.org/10.1038/s41598-022-13174-5
    • Tullemans, B. M. E., Brouns, S. L. N., Swieringa, F., Sabrkhany, S., van den Berkmortel, F. W. P. J., Peters, N. A. J. B., de Bruijn, P., Koolen, S. L. W., Heemskerk, J. W. M., Aarts, M. J. B., & Kuijpers, M. J. E. (2022). Quantitative and qualitative changes in platelet traits of sunitinib-treated patients with renal cell carcinoma in relation to circulating sunitinib levels: a proof-of-concept study. BMC Cancer, 22(1), Article 653. https://doi.org/10.1186/s12885-022-09676-0
    • van Paridon, P. C. S., Panova-Noeva, M., van Oerle, R., Schulz, A., Prochaska, J. H., Arnold, N., Schmidtmann, I., Beutel, M., Pfeiffer, N., Münzel, T., Lackner, K. J., Ten Cate, H., Wild, P. S., & Spronk, H. M. H. (2022). Relationships between coagulation factors and thrombin generation in a general population with arterial and venous disease background. Thrombosis Journal, 20(1), Article 32. https://doi.org/10.1186/s12959-022-00392-0
    • Lagedal, R., Eriksson, O., Sorman, A., Huckriede, J. B., Kristensen, B., Franzen, S., Larsson, A., Bergqvist, A., Alving, K., Forslund, A., Persson, B., Ekdahl, K. N., De Frutos, P. G., Nilsson, B., Nicolaes, G. A. F., Lipcsey, M., Hultstrom, M., & Frithiof, R. (2022). Impaired Antibody Response Is Associated with Histone-Release, Organ Dysfunction and Mortality in Critically Ill COVID-19 Patients. Journal of Clinical Medicine, 11(12), Article 3419. https://doi.org/10.3390/jcm11123419
    • Ottaviani, L., Juni, R. P., de Abreu, R. C., Sansonetti, M., Sampaio-Pinto, V., Halkein, J., Hegenbarth, J. C., Ring, N., Knoops, K., Kocken, J. M. M., Jesus, C. D., Ernault, A. C., El Azzouzi, H., Rühle, F., Olieslagers, S., Fernandes, H., Ferreira, L., Braga, L., Stoll, M., ... da Costa Martins, P. A. (2022). Intercellular transfer of miR-200c-3p impairs the angiogenic capacity of cardiac endothelial cells. Molecular Therapy, 30(6), 2257-2273. https://doi.org/10.1016/j.ymthe.2022.03.002
    • Dickhout, A., van de Vijver, P., Bitsch, N., van Hoof, S. J., Thomassen, S. L. G. D., Massberg, S., Timmerman, P., Verhaegen, F., Koenen, R. R., Dijkgraaf, I., & Hackeng, T. M. (2022). Molecular Detection of Venous Thrombosis in Mouse Models Using SPECT/CT. Biomolecules, 12(6), Article 829. https://doi.org/10.3390/biom12060829
    • Kawczynski, M. J., Zeemering, S., Gilbers, M., Isaacs, A., Verheule, S., Zink, M. D., Maesen, B., Bramer, S., Van Gelder, I. C., Crijns, H. J. G. M., Schotten, U., & Bidar, E. (2022). New-onset perioperative atrial fibrillation in cardiac surgery patients: transient trouble or persistent problem?-Authors' reply. EP Europace, 24(6), 1037-1038. Article 317. https://doi.org/10.1093/europace/euab317
    • Breidthardt, T., van Doorn, W. P. T. M., van der Linden, N., Diebold, M., Wussler, D., Danier, I., Zimmermann, T., Shrestha, S., Kozhuharov, N., Belkin, M., Porta, C., Strebel, I., Michou, E., Gualandro, D. M., Nowak, A., Meex, S. J. R., & Mueller, C. (2022). Diurnal Variations in Natriuretic Peptide Levels: Clinical Implications for the Diagnosis of Acute Heart Failure. Circulation-Heart Failure, 15(6), E009165. Article 009165. https://doi.org/10.1161/circheartfailure.121.009165
    • Lemmens, T. P., Coenen, D. M., Swieringa, F., Niessen, I. C. L., Coort, S. L. M., Koenen, R. R., Kutmon, M., & Cosemans, J. M. E. M. (2022). Finding the "switch" in platelet activation: prediction of key mediators involved in reversal of platelet activation using a novel network biology approach. Journal of Proteomics, 261, Article 104577. https://doi.org/10.1016/j.jprot.2022.104577
    • Willers, A., Swol, J., Buscher, H., McQuilten, Z., van Kuijk, S. M. J., Ten Cate, H., Rycus, P. T., McKellar, S., Lorusso, R., & Tonna, J. E. (2022). Longitudinal Trends in Bleeding Complications on Extracorporeal Life Support Over the Past Two Decades-Extracorporeal Life Support Organization Registry Analysis. Critical Care Medicine, 50(6), E569-E580. https://doi.org/10.1097/CCM.0000000000005466
    • Loots, F. J., Smits, M., Hopstaken, R. M., Jenniskens, K., Schroeten, F. H., van den Bruel, A., van de Pol, A. C., Oosterheert, J. J., Bouma, H., Little, P., Moore, M., van Delft, S., Rijpsma, D., Holkenborg, J., van Bussel, B. C., Laven, R., Bergmans, D. C., Hoogerwerf, J. J., Latten, G. H., ... Verheij, T. J. (2022). New clinical prediction model for early recognition of sepsis in adult primary care patients: a prospective diagnostic cohort study of development and external validation. British Journal of General Practice, 72(719), E437-E445. https://doi.org/10.3399/BJGP.2021.0520
    • Tamer, F., Tullemans, B. M. E., Kuijpers, M. J. E., Claushuis, T. A. M., & Heemskerk, J. W. M. (2022). Nutrition Phytochemicals Affecting Platelet Signaling and Responsiveness: Implications for Thrombosis and Hemostasis. Thrombosis and Haemostasis, 122(06), 879-894. https://doi.org/10.1055/a-1683-5599
    • Janssen, S. L. J. E., Aengevaeren, V. L., Bongers, C. C. W. G., Kleinnibbelink, G., de Vries, F., Mingels, A. M. A., Eijsvogels, T. M. H., & Hopman, M. T. E. (2022). Exercise-induced Cardiac Troponin T Release in Veteran Athletes Recovered from COVID-19. European Journal of Preventive Cardiology, 29(8), E279-E282. Article 035. https://doi.org/10.1093/eurjpc/zwac035
    • Lundstroem, A., Sanden, P., Mitroulis, I., & van der Meijden, P. E. J. (2022). Editorial: Platelet Function in COVID-19. Frontiers in Cardiovascular Medicine, 9, Article 912472. https://doi.org/10.3389/fcvm.2022.912472