Henri Spronk

Associate professor

Initially trained in Biochemistry and Molecular Biology at Nijmegen University, Dr Henri Spronk obtained a PhD in Biochemistry on the effects of impaired vitamin K-dependent protein carboxylation.

The focus of his current work is on the bidirectional relation between coagulation and inflammation, as well as on the applicability of functional plasma assays such as thrombin generation, for atherothrombotic risk prediction. He has a special interest in the role of active coagulation factors, mainly thrombin, in activation of protein-activated receptors (PARs) which can regulate the balance between vascular protective and disruptive. Overall, knowledge on the non-haemostatic functions of thrombin and factor Xa enables pharmacological interference in cellular processes contributing to the the development and progression of atherosclerosis or atrial fibrillation.

Department of Biochemistry
Department of Internal Medicine
Universiteitssingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: 4.326
T: +31(0)43 388 42 61

2012
- Beijers, H. J. B. H., Ferreira, I., Spronk, H. M. H., Bravenboer, B., Dekker, J. M., Nijpels, G., ten Cate, H., & Stehouwer, C. D. A. (2012). Impaired glucose metabolism and type 2 diabetes are associated with hypercoagulability: potential role of central adiposity and low-grade inflammation - The Hoorn Study. Thrombosis Research, 129(5), 557-562. https://doi.org/10.1016/j.thromres.2011.07.033
- Trappenburg, M. C., van Schilfgaarde, M., Frerichs, F. C. P., Spronk, H. M. H., ten Cate, H., de Fijter, C. W. H., Terpstra, W. E., & Leyte, A. (2012). Chronic renal failure is accompanied by endothelial activation and a large increase in microparticle numbers with reduced procoagulant capacity. Nephrology Dialysis Transplantation, 27(4), 1446-1453. https://doi.org/10.1093/ndt/gfr474
- Lecut, C., Faccinetto, C., Delierneux, C., Van Oerle, R., Spronk, H. M. H., Evans, R. J., El Benna, J., Bours, V., & Oury, C. (2012). ATP-gated P2X1 ion channels protect against endotoxemia by dampening neutrophil activation. Journal of Thrombosis and Haemostasis, 10(3), 453-465. https://doi.org/10.1111/j.1538-7836.2011.04606.x
2011
- Mahmoodi, B. K., Mulder, A. B., Waanders, F., Spronk, H. M. H., Mulder, E. R., Slagman, M. C. J., Vogt, L., Navis, G., Ten Cate, H., Kluin-Nelemans, H. C., & Laverman, G. D. (2011). The impact of antiproteinuric therapy on the prothrombotic state in patients with overt proteinuria. Journal of Thrombosis and Haemostasis, 9(12), 2416-2423. https://doi.org/10.1111/j.1538-7836.2011.04525.x
- Winckers, K., Siegerink, B., Duckers, C., Maurissen, L. F., Tans, G., Castoldi, E., Spronk, H. M. H., Ten Cate, H., Algra, A., Hackeng, T. M., & Rosendaal, F. R. (2011). Increased tissue factor pathway inhibitor activity is associated with myocardial infarction in young women: results from the RATIO study. Journal of Thrombosis and Haemostasis, 9(11), 2243-2250. https://doi.org/10.1111/j.1538-7836.2011.04497.x
- Honickel, M., Rieg, A. D., Rossaint, R., Braunschweig, T., Spronk, H. M. H., ten Cate, H., van Oerle, R., Tolba, R., & Grottke, O. (2011). Prothrombin complex concentrate reduces blood loss and enhances thrombin generation in a pig model with blunt liver injury under severe hypothermia. Thrombosis and Haemostasis, 106(4), 724-733. https://doi.org/10.1160/TH11-02-0101
- Grottke, O., Braunschweig, T., Spronk, H. M. H., Esch, S., Rieg, A. D., van Oerle, R., ten Cate, H., Fitzner, C., Tolba, R., & Rossaint, R. (2011). Increasing concentrations of prothrombin complex concentrate induce disseminated intravascular coagulation in a pig model of coagulopathy with blunt liver injury. Blood, 118(7), 1943-1951. https://doi.org/10.1182/blood-2011-03-343046
- Kilinc, E., Van Oerle, R., Borissoff, J. I., Oschatz, C., Gerlofs Nijland, M. E., Janssen, N. A., Cassee, F. R., Sandstrom, T., Renne, T., Ten Cate, H., & Spronk, H. M. H. (2011). Factor XII activation is essential to sustain the procoagulant effects of particulate matter. Journal of Thrombosis and Haemostasis, 9(7), 1359-1367. https://doi.org/10.1111/j.1538-7836.2011.04280.x
- Borissoff, J. I., Spronk, H. M. H., & ten Cate, H. (2011). MECHANISMS OF DISEASE The Hemostatic System as a Modulator of Atherosclerosis. New England Journal of Medicine, 364(18), 1746-1760. https://doi.org/10.1056/NEJMra1011670
- Trappenburg, M. C., van Schilfgaarde, M., Bredewold, E. O., van Aalderen, M. C., Spronk, H. M. H., ten Cate, H., Leyte, A., & Terpstra, W. E. (2011). Elevated numbers and altered subsets of procoagulant microparticles in breast cancer patients using endocrine therapy. Thrombosis Research, 127(4), 363-369. https://doi.org/10.1016/j.thromres.2010.12.015
- Panova-Noeva, M., Marchetti, M., Spronk, H. M., Russo, L., Diani, E., Finazzi, G., Salmoiraghi, S., Rambaldi, A., Barbui, T., Ten Cate, H., & Falanga, A. (2011). Platelet-induced thrombin generation by the calibrated automated thrombogram assay is increased in patients with essential thrombocythemia and polycythemia vera. American Journal of Hematology, 86(4), 337-342. https://doi.org/10.1002/ajh.21974
- Kilinc, E., Schulz, H., Kuiper, G. J. A. J. M., Spronk, H. M. H., ten Cate, H., Upadhyay, S., Ganguly, K., Stoeger, T., Semmler-Bhenke, M., Takenaka, S., Kreyling, W. G., Pitz, M., Reitmeir, P., Peters, A., Eickelberg, O., & Wichmann, H. E. (2011). The procoagulant effects of fine particulate matter in vivo. Particle and Fibre Toxicology, 8, 3. https://doi.org/10.1186/1743-8977-8-12
- Smid, M., Dielis, A. W. J. H., Winkens, M. H. M., Spronk, H. M. H., van Oerle, R., Hamulyak, K., Prins, M. H., Rosing, J., Waltenberger, J. L., & ten Cate, H. (2011). Thrombin generation in patients with a first acute myocardial infarction. Journal of Thrombosis and Haemostasis, 9(3), 450-456. https://doi.org/10.1111/j.1538-7836.2010.04162.x
2010
- Beijers, H. J. B. H., Ferreira, I., Spronk, H. M. H., Bravenboer, B., Dekker, J. M., Nijpels, G., ten Cate, H., & Stehouwer, C. D. A. (2010). Body composition as determinant of thrombin generation in plasma: the Hoorn study.Arteriosclerosis Thrombosis and Vascular Biology, 30(12), 2639-2647. https://doi.org/10.1161/ATVBAHA.110.211946
- Gerlofs-Nijland, M. E., Totlandsdal, A. I., Kilinc, E., Boere, J. A. F., Fokkens, P. H. B., Leseman, D. L. A. C., Sioutas, C., Schwarze, P. E., Spronk, H. M., Hadoke, P. W. F., Miller, M. R., & Cassee, F. R. (2010). Pulmonary and cardiovascular effects of traffic-related particulate matter: 4-week exposure of rats to roadside and diesel engine exhaust particles. Inhalation Toxicology, 22(14), 1162-1173. https://doi.org/10.3109/08958378.2010.531062
- Dargaud, Y., Spronk, H. M. H., Leenders, P., Hemker, H. C., & Ten Cate, H. (2010). Monitoring platelet dependent thrombin generation in mice. Thrombosis Research, 126(5), 436-441. https://doi.org/10.1016/j.thromres.2010.08.007
- Borissoff, J. I., Heeneman, S., Kilinc, E., Kassak, P., Van Oerle, R., Winckers, K., Govers-Riemslag, J. W. P., Hamulyak, K., Hackeng, T. M., Daemen, M. J. A. P., Ten Cate, H., & Spronk, H. M. H. (2010). Early Atherosclerosis Exhibits an Enhanced Procoagulant State. Circulation, 122(8), 821-U145. https://doi.org/10.1161/CIRCULATIONAHA.109.907121
- Knottnerus, I. L. H., Govers-Riemslag, J. W. P., Hamulyak, K., Rouhl, R. P. W., Staals, J., Spronk, H. M. H., van Oerle, R., van Raak, E. P. M., Lodder, J., ten Cate, H., & van Oostenbrugge, R. J. (2010). Endothelial Activation in Lacunar Stroke Subtypes. Stroke, 41(8), 1617-1622. https://doi.org/10.1161/STROKEAHA.109.576223
- Loubele, S. T. B. G., ten Cate, H., & Spronk, H. M. H. (2010). Anticoagulant therapy in critical organ ischaemia/reperfusion injury. Thrombosis and Haemostasis, 104(1), 136-142. https://doi.org/10.1160/TH09-08-0582

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Henri Spronk

Associate professor