Pieter Goossens

Post doc

Dr Pieter Goossens graduated in 2012 at the Maastricht University, studying atherosclerotic plaque macrophage accumulation in the group of Prof. Menno de Winther (Department of Molecular Genetics ). He then joined the lab of Dr Toby Lawrence at the Centre d’Immunologie de Marseille-Luminy in Marseille (France) as a post-doctoral researcher, where he investigated the mechanisms through which tumor-associated macrophages obtain their characteristic phenotype. In 2016, he returned to the Maastricht University where, in the lab of Prof. Erik Biessen at the Department of Pathology, he studies macrophage phenotypical and functional heterogeneity in the atherosclerosis context.

Macrophages display a high degree of phenotypic heterogeneity that reflects the cells’ micro-environment. Pieter combines classical histology with transcriptomics, multi-label fluorescent microscopy and mass spectrometry imaging to study the spatial distribution of macrophage subsets in human and murine atherosclerotic plaques and the impact of local triggers on their phenotype and functions.

Department of Pathology
P. Debyelaan 25, 6229 HX Maastricht
Room number: 5.06
T: +31(0)43 387 46 30

2024
- Medina, I., Wieland, E. B., Temmerman, L., Otten, J. J. T., Bermudez, B., Bot, I., Rademakers, T., Wijnands, E., Schurgers, L., Mees, B., van Berkel, T. J. C., Goossens, P., & Biessen, E. A. L. (2024). Colony stimulating factor 1 receptor (Csf1r) expressing cell ablation in mafia (macrophage-specific Fas-induced apoptosis) mice alters monocyte landscape and atherosclerotic lesion characteristics. European Journal of Immunology, 54(11), Article 2350943. https://doi.org/10.1002/eji.202350943
- Jin, H., Zhang, C., Nagenborg, J., Juhasz, P., Ruder, A. V., Sikkink, C. J. J. M., Mees, B. M. E., Waring, O., Sluimer, J. C., Neumann, D., Goossens, P., Donners, M. M. P. C., Mardinoglu, A., & Biessen, E. A. L. (2024). Genome-scale metabolic network of human carotid plaque reveals the pivotal role of glutamine/glutamate metabolism in macrophage modulating plaque inflammation and vulnerability. Cardiovascular Diabetology, 23(1), Article 240. https://doi.org/10.1186/s12933-024-02339-3
- Cao, J., Martin-Lorenzo, M., van Kuijk, K., Wieland, E., Gijbels, M. J., Claes, B. S. R., Heredero, A., Aldamiz-Echevarria, G., Heeren, R. M. A., Goossens, P., Sluimer, J., Balluff, B., & Alvarez-Llamas, G. (2024). Spatial Metabolomics Identifies LPC(18:0) and LPA(18:1) in Advanced Atheroma With Translation to Plasma for Cardiovascular Risk Estimation. Arteriosclerosis Thrombosis and Vascular Biology, 44(3), 741-754. https://doi.org/10.1161/ATVBAHA.123.320278
- Lu, C., Donners, M. M. P. C., de Baaij, J. B. J., Jin, H., Otten, J. J. T., Manca, M., van Zonneveld, A. J., Jukema, J. W., Kraaijeveld, A., Kuiper, J., Pasterkamp, G., Mees, B., Sluimer, J. C., Cavill, R., Karel, J. M. H., Goossens, P., & Biessen, E. A. L. (2024). Identification of a gene network driving the attenuated response to lipopolysaccharide of monocytes from hypertensive coronary artery disease patients. Frontiers in Immunology, 15, Article 1286382. https://doi.org/10.3389/fimmu.2024.1286382
- Wieland, E. B., Kempen, L. J., Donners, M. M., Biessen, E. A., & Goossens, P. (2024). Macrophage heterogeneity in atherosclerosis: A matter of context. European journal of immunology, 54(1), Article 2350464. https://doi.org/10.1002/eji.202350464
2023
- Wieland, E. B., Kempen, L. J. A. P., Lu, C., Donners, M. M. P. C., Biessen, E. A. L., & Goossens, P. (2023). Protocol for multispectral imaging on cryosections to map myeloid cell heterogeneity in its spatial context. STAR protocols, 4(4), Article 102601. https://doi.org/10.1016/j.xpro.2023.102601
- Lu, C., Donners, M. M. P. C., Karel, J., de Boer, H., van Zonneveld, A. J., den Ruijter, H., Jukema, J. W., Kraaijeveld, A., Kuiper, J., Pasterkamp, G., Cavill, R., Perales-Patón, J., Ferrannini, E., Goossens, P., & Biessen, E. A. L. (2023). Sex-specific differences in cytokine signaling pathways in circulating monocytes of cardiovascular disease patients. Atherosclerosis, 384, Article 117123. https://doi.org/10.1016/j.atherosclerosis.2023.04.005
- Nagenborg, J., Jin, H., Ruder, A. V., Temmerman, L., Mees, B., Schalkwijk, C., Müller-Klieser, D., Berg, T., Goossens, P., Donners, M. M. P. C., & Biessen, E. A. L. (2023). GM-CSF-activated STAT5A regulates macrophage functions and inflammation in atherosclerosis. Frontiers in Immunology, 14, Article 1165306. https://doi.org/10.3389/fimmu.2023.1165306
- Ruder, A., Wetzels, S. M. W., Temmerman, L., Biessen, E. A. L., & Goossens, P. (2023). Monocyte heterogeneity in cardiovascular disease. Cardiovascular Research, 119(11), 2033-2045. https://doi.org/10.1093/cvr/cvad069
- van Kuijk, K., McCracken, I. R., Tillie, R. J. H. A., Asselberghs, S. E. J., Kheder, D. A., Muitjens, S., Jin, H., Taylor, R. S., Schreur, R. W., Kuppe, C., Dobie, R., Ramachandran, P., Gijbels, M. J., Temmerman, L., Kirkwoord, P. M., Luyten, J., Li, Y. M., Noels, H., Goossens, P., ... Sluimer, J. C. (2023). Human and murine fibroblast single-cell transcriptomics reveals fibroblast clusters are differentially affected by ageing and serum cholesterol. Cardiovascular Research, 119(7), 1509-1523. https://doi.org/10.1093/cvr/cvad016

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Pieter Goossens

Post doc