Jack Cleutjens

Associate professor

Dr Jack Cleutjens has been working for Maastricht University since 1985. After finishing his thesis 'Basement membrane heterogeneity' in 1989, he started working in the cardiovascular field as a post-doc on the regulation of the wound healing after myocardial infarction. His main interest is in the area of extracellular matrix remodeling, mainly collagen synthesis and degradation.

His area of focus is education and cardiovascular research. He is a specialist in the field of morphometry and (digital) microscopy. Jack Cleutjens is a member of the Dutch Society of Pathology, Experimental Pathology section and of the Dutch Society for Matrix Biology.

Focus areas:
• Cardiovascular examination
• Extracellular matrix turnover
• Myocardial infarction / atherosclerosis
• (Digital) microscopy
• Morphometry

Department of Pathology
Verheylaan 10, 6229 HX Maastricht
Room number: VH10 5.M1-002
T: +31(0)43 387 66 31

2023
- van der Weijden, J., De Hoogt, P. A., Leufkens, M. M. E., Keijbeck, A. A., van Goor, H., van den Heuvel, M. C., Cleutjens, J. P. M., Moers, C., Snoeijs, M. G., Navis, G. J., van Londen, M., Nolte, I. M., Berger, S. P., De Borst, M. H., & Peutz-Kootstra, C. J. (2023). The relationship of peritubular capillary density with glomerular volume and kidney function in living kidney donors. Journal of Nephrology, 36(7), 2111-2124. https://doi.org/10.1007/s40620-023-01734-5
- Ganizada, B. H., Reesink, K. D., Parikh, S., Ramaekers, M. J. F. G., Akbulut, A. C., Saraber, P. J. M. H., Debeij, G. P., Jaminon, A. M., Natour, E., Lorusso, R., Wildberger, J. E., Mees, B., Schurink, G. W., Jacobs, M. J., Cleutjens, J., Krapels, I., Gombert, A., Maessen, J. G., Accord, R., ... MUMC TAA Student Team (2023). The Maastricht Acquisition Platform for Studying Mechanisms of Cell-Matrix Crosstalk (MAPEX): An Interdisciplinary and Systems Approach towards Understanding Thoracic Aortic Disease. Biomedicines, 11(8), Article 2095. https://doi.org/10.3390/biomedicines11082095
- Keijbeck, A., Raaijmaakers, A., Hillen, L., Gelens, M., van Kuijk, S., Cleutjens, J. P., Peutz-Kootstra, C., & Christiaans, M. (2023). Visual interstitial fibrosis assessment as continuous variable in protocol renal transplant biopsies. Histopathology, 82(5), 713-721. https://doi.org/10.1111/his.14857
2022
- Moshi, J. M., Ummelen, M., Broers, J. L. V., Smedts, F., Van de Vijver, K. K., Cleutjens, J. P. M., Litjens, R. J. N. T. M., Ramaekers, F. C. S., & Hopman, A. H. N. (2022). SOX2 expression in the pathogenesis of premalignant lesions of the uterine cervix: its histo-topographical distribution distinguishes between low- and high-grade CIN. Histochemistry and Cell Biology, 158(6), 545-559. https://doi.org/10.1007/s00418-022-02145-6
- Kuiper, S. Z., Tol, R. R. V., Lataster, A., Cleutjens, J. P. M., Melenhorst, J., Dijk, P. V., Van Kuijk, S. M. J., & Breukink, S. O. (2022). A Morphometric Analysis of Pathological Alterations in Hemorrhoidal Disease Versus Normal Controls: A Controlled Trial. Journal of Coloproctology, 42(2), 140-145. https://doi.org/10.1055/s-0041-1742257
2021
- Widowski, H., Ophelders, D. R. M. G., van Leeuwen, A. J. C. N., Nikkels, P. G. J., Severens-Rijvers, C. A. H., LaPointe, V. L. S., Cleutjens, J. P. M., Hütten, M. C., Kemp, M. W., Payne, M. S., Saito, M., Usuda, H., Newnham, J. P., Jobe, A. H., Kramer, B. W., Delhaas, T., Wolfs, T. G. A. M., & Reynaert, N. L. (2021). Chorioamnionitis induces changes in ovine pulmonary endogenous epithelial stem/progenitor cells in utero. Pediatric Research, 90(3), 549-558. https://doi.org/10.1038/s41390-020-01204-9
- Widowski, H., Reynaert, N. L., Ophelders, D. R. M. G., Hütten, M. C., Nikkels, P. G. J., Severens-Rijvers, C. A. H., Cleutjens, J. P. M., Kemp, M. W., Newnham, J. P., Saito, M., Usuda, H., Payne, M. S., Jobe, A. H., Kramer, B. W., Delhaas, T., & Wolfs, T. G. A. M. (2021). Sequential Exposure to Antenatal Microbial Triggers Attenuates Alveolar Growth and Pulmonary Vascular Development and Impacts Pulmonary Epithelial Stem/Progenitor Cells. Frontiers in medicine, 8, Article 614239. https://doi.org/10.3389/fmed.2021.614239
- van Gorp, C., de Lange, I. H., Massy, K. R. I., Kessels, L., Jobe, A. H., Cleutjens, J. P. M., Kemp, M. W., Saito, M., Usada, H., Newnham, J., Hütten, M., Kramer, B. W., Zimmermann, L. J., & Wolfs, T. G. A. M. (2021). Intestinal Goblet Cell Loss during Chorioamnionitis in Fetal Lambs: Mechanistic Insights and Postnatal Implications. International journal of molecular sciences, 22(4), Article 1946. https://doi.org/10.3390/ijms22041946
- Heij, L. R., Tan, X., Kather, J. N., Niehues, J. M., Sivakumar, S., Heussen, N., van der Kroft, G., Damink, S. W. M. O., Lang, S., Aberle, M. R., Luedde, T., Gaisa, N. T., Bednarsch, J., Liu, D. H. W., Cleutjens, J. P. M., Modest, D. P., Neumann, U. P., & Wiltberger, G. J. (2021). Nerve Fibers in the Tumor Microenvironment Are Co-Localized with Lymphoid Aggregates in Pancreatic Cancer. Journal of Clinical Medicine, 10(3), Article 490. https://doi.org/10.3390/jcm10030490
2018
- Bijnen, M., Beelen, N., Wetzels, S., van De Gaar, J., Vroomen, M., Wijnands, E., Scheijen, J. L., van de Waarenburg, M. P. H., Gijbels, M. J., Cleutjens, J. P., Biessen, E. A. L., Stehouwer, C. D. A., Schalkwijk, C. G., & Wouters, K. (2018). RAGE deficiency does not affect non-alcoholic steatohepatitis and atherosclerosis in Western type diet-fed Ldlr(-/-) mice. Scientific Reports, 8(1), Article 15256. https://doi.org/10.1038/s41598-018-33661-y

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Team Science grant Uyen Nguyen and Roel Meiburg

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ZonMw grant on appropriate palliative care

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Jack Cleutjens

Associate professor