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CARIM's Confidential Contact Persons

CARIM's Confidential Contact Persons

27 November 2024

Dr Magdi Nagy (Dept of Biochemistry) and Prof. Peter de Leeuw (Dept of Internal Medicine) have been appointed as CARIM Confidential Contact Persons.

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ZonMw grant on appropriate palliative care

ZonMw grant on appropriate palliative care

27 November 2024

Prof. Marc Hemmelder (Dept of Internal Medicine) and his team received a ZonMw grant to promote early palliative care for dialysis patients who are non-waitlisted for transplantation.

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Carim Maastricht
Carim Maastricht

Iwan van der Horst

Professor

 Prof. Iwan van der Horst was the principal investigator of the Simple Intensive Care Studies (SICS). In this ongoing registry, up to 2000 patients were included to unravel the diagnostic and prognostic value of physical and physiological examination. Based on the variables included, physicians make clinical decisions in the sickest patients every day. The design paper is published in the BMJ Open.

He was a leading investigator of clinical studies on critically ill patients focusing on hemodynamics, the heart in non-cardiac disease and acute kidney failure at the ICU. The team was involved in initiatives that combine the best of a prospective cohort study (like SICS-I, SOCCS and SICS-II) and randomised controlled trial design. The protocols were based upon results of systematic reviews (see Prospero).

He was also a co-primary investigator in clinical studies on myocardial infarction and heart failure, especially about (glucose) metabolism. Like the Metformin to Reduce Heart Failure After Myocardial Infarction (GIPS-III), NCT01217307. With this study, they obtained a grant of the Netherlands Organization for Health Research and Development (ZonMW; project no. 40-41200-98-9139). Over 20 publications out of this structured study have been published.

Therefore, he was an investigator in the Glucose Insulin Potassium Study (GIPS) I and II, both supported by the Netherlands Heart Foundation (99.028 and 2003B277). Studies on the diagnostic and prognostic value of routine laboratory measures in critically ill patients and implementation study on secondary prevention.

Currently, he is part of a team dedicated to monitoring and big data in critical care patients. A big database is created and cleaned for specific questions regarding mortality. The first projects focus on clustering and validation of prediction models. With the heart on team science, this research line is open to collaboration.

Iwanvdhorst1

Department of Intensive Care
P. Debyelaan 25
6229 HX, Maastricht
Room number: 3.C1.056  
T: +31(0)43 387 63 87 

  • 2024
    • Meijs, D. A. M., Wynants, L., van Kuijk, S. M. J., Scheeren, C. I. E., Hana, A., Mehagnoul-Schipper, J., Stessel, B., Vander Laenen, M., Cox, E. G. M., Sels, J. W. E. M., Smits, L. J. M., Bickenbach, J., Mesotten, D., van der Horst, I. C. C., Marx, G., van Bussel, B. C. T., CoDaP Investigators, Heijnen, N., Mulder, M., ... Ghossein, C. (2024). Boosting the accuracy of existing models by updating and extending: using a multicenter COVID-19 ICU cohort as a proxy. Scientific Reports, 14(1), Article 26344. https://doi.org/10.1038/s41598-024-70333-6
    • Willers, V., Krumeich, J. R. L., Hulshof, A.-M., Buise, M. P., van der Horst, I. C. C., Henskens, Y. M. C., van Bussel, B. C. T., & Kuiper, G. J. A. J. M. (2024). Comparison of the Quantra QPlus and ROTEM Goal-Directed Transfusion Protocols in Cardiothoracic Surgery Patients: A Prospective Observational Study. Journal of Cardiothoracic and Vascular Anesthesia, 38(11), 2559-2566. https://doi.org/10.1053/j.jvca.2024.07.046
    • van de Koolwijk, A. F., Delnoij, T. S. R., Suverein, M. M., Essers, B. A. B., Hermanides, R. C., Otterspoor, L. C., Elzo Kraemer, C. V., Vlaar, A. P. J., van der Heijden, J. J., Scholten, E., den Uil, C. A., Dos Reis Miranda, D., Akin, S., de Metz, J., van der Horst, I. C. C., Winkens, B., Maessen, J. G., Lorusso, R., van de Poll, M. C. G., & INCEPTION-investigators (2024). Health-related quality of life one year after refractory cardiac arrest treated with conventional or extracorporeal CPR; a secondary analysis of the INCEPTION-trial. Resuscitation Plus, 19, Article 100669. https://doi.org/10.1016/j.resplu.2024.100669
    • Ghossein, M. A., de Kok, J. W. T. M., Eerenberg, F., van Rosmalen, F., Boereboom, R., Duisberg, F., Verharen, K., Sels, J. E. M., Delnoij, T., Geyik, Z., Mingels, A. M. A., Meex, S. J. R., van Kuijk, S. M. J., van Stipdonk, A. M. W., Ghossein, C., Prinzen, F. W., van der Horst, I. C. C., Vernooy, K., van Bussel, B. C. T., & Driessen, R. G. H. (2024). Monitoring of myocardial injury by serial measurements of QRS area and T area: The MaastrICCht cohort. Annals of Noninvasive Electrocardiology, 29(5), Article e70001. https://doi.org/10.1111/anec.70001
    • de Kok, J., van Bussel, B. C. T., van der Horst, I., & van Rosmalen, F. (2024). Improved reporting of selection processes in clinical database research; author's reply. Journal of Clinical Epidemiology, 173, Article 111394. https://doi.org/10.1016/j.jclinepi.2024.111394
    • Heines, S. J. H., de Jongh, S. A. M., de Jongh, F. H. C., Segers, R. P. J., Gilissen, K. M. H., van der Horst, I. C. C., van Bussel, B. C. T., & Bergmans, D. C. J. J. (2024). A novel positive end-expiratory pressure titration using electrical impedance tomography in spontaneously breathing acute respiratory distress syndrome patients on mechanical ventilation: an observational study from the MaastrICCht cohort. Journal of Clinical Monitoring and Computing. Advance online publication. https://doi.org/10.1007/s10877-024-01212-8
    • Heuts, S., Bova, R., Romeo, J. L. R., Vriesendorp, P. A., Van Der Horst, I. C. C., Segers, P., Maessen, J. G., Gollman-Tepeköylü, C., Van 't Hof, A. W. J., Bidar, E., & Lux, A. (2024). The prognostic impact of unplanned invasive coronary angiography following coronary artery bypass grafting. European Journal of Cardio-Thoracic Surgery, 66(2), Article ezae304. https://doi.org/10.1093/ejcts/ezae304
    • Romeo, J. L., Vriesendorp, P. A., Gerritsen, K., Nader, M., Mahtab, E., Maessen, J. G., van 't Hof, A. W. J., Gollmann-Tepeköylü, C., van Rosmalen, F., van der Horst, I. C. C., Mingels, A. M. A., & Heuts, S. (2024). Modeling creatine-kinase MB concentrations following coronary artery bypass grafting. Journal of Thoracic and Cardiovascular Surgery. Advance online publication. https://doi.org/10.1016/j.jtcvs.2024.08.019
    • Al Ali, L., Meijers, W. C., Beldhuis, I. E., Groot, H. E., Lipsic, E., van Veldhuisen, D. J., Voors, A. A., van der Horst, I. C. C., de Boer, R. A., & van der Harst, P. (2024). Association of fibrotic markers with diastolic function after STEMI. Scientific Reports, 14(1), Article 19122. https://doi.org/10.1038/s41598-024-69926-y
    • Bels, J. L. M., Thiessen, S., van Gassel, R. J. J., Beishuizen, A., Dekker, A. D. B., Fraipont, V., Lamote, S., Ledoux, D., Scheeren, C., De Waele, E., van Zanten, A. R. H., Bormans-Russell, L., van Bussel, B. C. T., Dictus, M. M. J., Fivez, T., Harks, I., van der Horst, I. C. C., Jonckheer, J., Marechal, H., ... PRECISe study team (2024). Effect of high versus standard protein provision on functional recovery in people with critical illness (PRECISe): an investigator-initiated, double-blinded, multicentre, parallel-group, randomised controlled trial in Belgium and the Netherlands. Lancet, 404(10453), 659-669. https://doi.org/10.1016/S0140-6736(24)01304-7
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