Hans Ippel

Technical staff

Hans Ippel studied Chemistry at Leiden University and received his PhD degree (1992) in Chemistry at Leiden University as well. He has worked as post-doc researcher in several job positions at Nijmegen University, Umeå University (Sweden), Wageningen University, and Utrecht University, and was also shortly employed as bioinformatician at the biotech company Catchmabs in Wageningen. In 2011, he joined the Biochemistry group of Tilman Hackeng, working as senior researcher doing structural NMR spectroscopy of peptides and proteins. He is currently employed as supervisor of the NMR facility supporting various academic researchers at CARIM and Maastricht UMC+. In addition, he is responsible for assisting external NMR users and doing contract work to third parties. Besides having expertise in structural biophysics and bioinformatics, Hans is an avid collector of Natural Art and all kinds of science stuff.

Research topics of interest are blood coagulation factors and potent inhibitory chemokines and peptides, e.g. derived from ticks. Here, NMR spectroscopy is used to determine 3D structures of native protein and the protein-target complex, in order to come up with new ways of drug targeting. Another research topic is on the structural biology of galectins (such as Gal1, Gal3 and Gal8) that are important proteins involved in cancer development. It is a collaboration project carried out between CARIM and the groups of Prof. Kevin Mayo (Minnesota University) and Prof Christian Weber (LUM München). NMR is also applied for metabolomic profiling of patients blood and urine samples, as well as being used as a structural validation tool towards the design of smart biopolymers.

Department of Biochemistry
Universiteitsingel 50, 6229 ER Maastricht
PO Box 616, 6200 MD Maastricht
Room number: H4.301
T: +31(0)43-388 24 92

2024
- Ippel, H., Miller, M. C., Dings, R. P. M., Ludwig, A.-K., Gabius, H.-J., & Mayo, K. H. (2024). Cysteine Oxidation in Human Galectin-1 Occurs Sequentially via a Folded Intermediate to a Fully Oxidized Unfolded Form. International Journal of Molecular Sciences, 25(13), Article 6956. https://doi.org/10.3390/ijms25136956
- Xiong, W., Chai, J., Wu, J., Li, J., Lu, W., Tian, M., Jmel, M. A., Ippel, J. H., Kotsyfakis, M., Dijkgraaf, I., Liu, S., & Xu, X. (2024). Cathelicidin-HG Alleviates Sepsis-Induced Platelet Dysfunction by Inhibiting GPVI-Mediated Platelet Activation. Research (Washington, D.C.), 7, Article 0381. https://doi.org/10.34133/research.0381
2023
- Chai, J., Wu, J., Li, J., Liao, H., Lu, W., Guo, R., Shao, Z., Jmel, M. A., Martins, L. A., Hackeng, T., Ippel, H., Dijkgraaf, I., Kotsyfakis, M., & Xu, X. (2023). Novel Amphibian Bowman-Birk-Like Inhibitor with Antioxidant and Anticoagulant Effects Ameliorates Pancreatitis Symptoms in Mice. Journal of Medicinal Chemistry, 66(17), 11869-11880. https://doi.org/10.1021/acs.jmedchem.3c00475
- Wang, R., Damanik, F., Kuhnt, T., Jaminon, A., Hafeez, S., Liu, H., Ippel, H., Dijkstra, P. J., Bouvy, N., Schurgers, L., ten Cate, A. T., Dias, A., Moroni, L., & Baker, M. B. (2023). Biodegradable Poly(ester) Urethane Acrylate Resins for Digital Light Processing: From Polymer Synthesis to 3D Printed Tissue Engineering Constructs. Advanced Healthcare Materials, 12(17), Article 2202648. https://doi.org/10.1002/adhm.202202648
2022
- Brandhofer, M., Hoffmann, A., Blanchet, X., Siminkovitch, E., Rohlfing, A. K., El Bounkari, O., Nestele, J. A., Bild, A., Kontos, C., Hille, K., Rohde, V., Froehlich, A., Golemi, J., Gokce, O., Krammer, C., Scheiermann, P., Tsilimparis, N., Sachs, N., Kempf, W. E., ... Bernhagen, J. (2022). Heterocomplexes between the atypical chemokine MIF and the CXC-motif chemokine CXCL4L1 regulate inflammation and thrombus formation. Cellular and Molecular Life Sciences, 79(10), Article 512. https://doi.org/10.1007/s00018-022-04539-0
- Leberzammer, J., Agten, S. M., Blanchet, X., Duan, R., Ippel, H., Megens, R. T. A., Schulz, C., Aslani, M., Duchene, J., Döring, Y., Jooss, N. J., Zhang, P., Brandl, R., Stark, K., Siess, W., Jurk, K., Heemskerk, J. W. M., Hackeng, T. M., Mayo, K. H., ... von Hundelshausen, P. (2022). Targeting platelet-derived CXCL12 impedes arterial thrombosis. Blood, 139(17), 2691-2705. https://doi.org/10.1182/blood.2020010140
- Poelman, H., Ippel, H., Gurkan, B., Boelens, R., Vriend, G., van 't Veer, C., Lutgens, E., & Nicolaes, G. A. F. (2022). Structural anomalies in a published NMR-derived structure of IRAK-M. Journal of Molecular Graphics & Modelling, 111, Article 108061. https://doi.org/10.1016/j.jmgm.2021.108061
2021
- Bervoets, L., Ippel, J. H., Smolinska, A., van Best, N., Savelkoul, P. H. M., Mommers, M. A. H., & Penders, J. (2021). Practical and Robust NMR-Based Metabolic Phenotyping of Gut Health in Early Life. Journal of Proteome Research, 20(11), 5079-5087. https://doi.org/10.1021/acs.jproteome.1c00617
- Denisov, S. S., Ippel, J. H., Castoldi, E., Mans, B. J., Hackeng, T. M., & Dijkgraaf, I. (2021). Molecular basis of anticoagulant and anticomplement activity of the tick salivary protein Salp14 and its homologs. Journal of Biological Chemistry, 297(1), Article 100865. https://doi.org/10.1016/j.jbc.2021.100865
- Miller, M. C., Zheng, Y., Suylen, D., Ippel, H., Canada, F. J., Berbis, M. A., Jimenez-Barbero, J., Tai, G., Gabius, H.-J., & Mayo, K. H. (2021). Targeting the CRD F-face of Human Galectin-3 and Allosterically Modulating Glycan Binding by Angiostatic PTX008 and a Structurally Optimized Derivative. Chemmedchem, 16(4), 713-723. https://doi.org/10.1002/cmdc.202000742

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Hans Ippel

Technical staff